| Sumario: | One strategy cells use for regulation is modifying proteins, DNA, and RNA to control their structure, function, and stability. For years, research has focused on the reversible modifications to proteins and DNA. However, RNA can also be highly modified, and more than 170 types of modification to RNA have been identified so far. Current methods for mapping and sequencing RNA and its modifications -- also known as the epitranscriptome -- are limited, partly because available sequencing technologies can detect only a small number of them. This limits the understanding of different molecular processes and leaves a gap in knowledge related to human diseases and disorders. To address these limitations and develop a roadmap for the sequencing of RNA with the epitranscriptome, the National Academies of Sciences, Engineering, and Medicine convened an ad hoc committee to provide a consensus report. A workshop held on March 14-15, 2023 was one part of an information-gathering effort by the committee and is summarized in this proceedings.
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