Dose finding by the continual reassessment method
As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to ""novel"" methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much atte...
| Autor principal: | |
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| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Boca Raton :
Taylor & Francis
2011.
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| Edición: | 1st edition |
| Colección: | Chapman & Hall/CRC biostatistics series ;
41. |
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009627931506719 |
Tabla de Contenidos:
- Dose finding in clinical trials
- The continual reassessment method
- One-parameter dose toxicity models
- Theoretical properties
- Empirical properties
- Specifications of a CRM design
- Initial guesses of toxicity probabilities
- Least informative normal prior
- Initial design
- The time-to-event CRM
- CRM with multiparameter models
- When the CRM fails
- Stochastic approximation.
- pt. 1. Fundamentals
- pt. 2. Design Calibration
- pt. 3. CRM and beyond.
