“…Technologies to Enable Autonomous Detection for BioWatch is the summary of a workshop hosted jointly by the Institute of Medicine and the National Research Council in June 2013 to explore alternative cost-effective systems that would meet the requirements for a BioWatch Generation 3.0 autonomous detection system, or autonomous detector, for aerosolized agents . …”

Tabla de Contenidos: “…Varieties of Toxic Responses -- Metabolism of Chemical Carcinogens -- Effects on the Immune System -- SUMMARY -- SUMMARY OF RESEARCH RECOMMENDATIONS -- ACKNOWLEDGMENTS -- References -- Transport and Uptake of Inhaled Gases -- IMPLICATIONS OF LUNG ANATOMY -- Upper Airways -- Conducting Airways -- Respiratory Zone -- Nonuniformities in Ventilation and Perfusion -- FUNDAMENTALS OF MASS TRANSPORT -- Thermodynamic Equilibria -- Diffusion and Reaction Rates -- Individual Mass Transfer Coefficients -- Overall Mass Transfer Coefficients -- Longitudinal Gas Transport -- MATHEMATICAL MODELS -- Compartment Models -- Distributed-Parameter Upper Airway Models -- Distributed-Parameter Lower Airway Models -- EXPERIMENTS -- In Vitro Methods -- In Vivo Animal Experiments -- In Vivo Human Subject Studies -- SUMMARY -- SUMMARY OF RESEARCH RECOMMENDATIONS -- ACKNOWLEDGMENT -- References -- Dosimetry Modeling of Inhaled Toxic Reactive Gases -- APPLICATIONS OF DOSIMETRY MODELING -- ANATOMICAL, PHYSIOLOGICAL, AND CHEMICAL CONSIDERATIONS -- Anatomical Models -- Liquid Lining of the Respiratory Tract -- Lung Tissue and Blood -- PHYSICAL AND CHEMICAL FACTORS AFFECTING ABSORPTION OF REACTIVE GASES -- Solubility -- Molecular Diffusion -- Convection in Respiratory Tract Fluids -- Chemical Reactions -- DOSIMETRY MODELING -- Upper Respiratory Tract and Total Respiratory Tract Models -- Lower Respiratory Tract Models -- Influence of Anatomical and Physiological Factors -- Influence of Physicochemical Factors -- Importance of Experimental Data -- SUMMARY -- SUMMARY OF RESEARCH RECOMMENDATIONS -- References -- Part III: Biological Effects -- Epidemiologic Studies of Effects of Oxidant Exposure on Human Populations -- ROLE OF EPIDEMIOLOGY IN AIR POLLUTION RESEARCH -- PRIOR AND ONGOING STUDIES-DESIGNS, FINDINGS, AND PROBLEMS -- Cross-Sectional Studies of Pulmonary Function and Symptoms…”