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  1. 13761
    por Institute of Medicine (U.S.)
    Publicado 2011
    “…"Despite the many basic research discoveries in genetics, relatively few gene-based treatments, drugs, or preventative measures have been developed. …”
    Libro electrónico
  2. 13762
    Publicado 1982
    Libro
  3. 13763
    Publicado 2017
    “…Given the wide range of species, gene families, and developmental processes considered, a concerted effort is still required to shed light on the genetic, cellular and molecular mechanisms involved in phenotypic evolution. …”
    Libro electrónico
  4. 13764
    Publicado 2023
    “…Therefore, Precision Nutrition includes personalized advice based on genetics and well-documented gene-nutrient-phenotype interactions, as well as other factors such as individual metabolome, transcriptome, and microbiota profile; food behavior; and dietary, physical activity, and life-style habits; and the resulting interactomes. …”
    Libro electrónico
  5. 13765
    Publicado 2016
    “…The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. …”
    Libro electrónico
  6. 13766
    Publicado 2019
    “…What are the objectives of the genetic study of individuals? There is great interest from the medical community and also much concern from the lay press about the potential benefits and harms of genetic screening, gene therapy, and even the possibility of cloning individuals. …”
    Libro electrónico
  7. 13767
    Publicado 2014
    “…Pancreatic stellate cells attract the researchers as a novel therapeutic target of pancreatic cancer. Genetic studies have shown that mutations in the trypsin-related genes such as cationic trypsinogen (PRSS1) gene and the serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with pancreatitis. …”
    Libro electrónico
  8. 13768
    por Gaiman, Neil
    Publicado 2017
    Tabla de Contenidos: “…Algunas personas a las que he conocido -- No son nuestras caras -- «Reflections»: a propósito de Diana Wynne Jones -- Terry Pratchett: un reconocimiento -- A propósito de Dave McKean -- Cómo leer a Gene Wolfe -- Recuerdos de Douglas Adams -- Harlan Ellison y «La bestia que gritaba amor en el corazón del universo» -- El tamborilero de Harlan Ellison -- A propósito de Stephen King: una entrevista para «The Sunday Times» 135 -- Geoff Notkin: el hombre de los meteoritos -- En torno a Kim Newman, con algunos apuntes sobre la creación y la disolución final de la Peace and Love Corporation -- «Gumshoe»: una reseña -- «SimCity» -- De seis a seis -- 3. …”
    Libro electrónico
  9. 13769
    Publicado 2017
    Tabla de Contenidos: “…Data Issues -- Data Quality -- Overfitting and Spurious Correlations -- Certain Problems May Call for a More Traditional Approach to Analytics -- The Limitations of Agile Analytics -- Acting Prematurely -- Even Agile Analytics Can't Do Everything -- Agile Analytics Won't Overcome a Fundamentally Bad Idea -- Next -- Chapter 14: The Importance of Designing for Data: Lessons from the Upstarts -- The Genes of Music -- From Theory to Practice -- The Tension between Data and Design -- All Design Is Not Created Equal -- Data and Design Can-Nay, Should-Coexist -- Next -- Notes -- Part FIVE Conclusions and Next Steps -- Chapter 15: What Now?…”
    Libro electrónico
  10. 13770
    Publicado 2012
    Tabla de Contenidos: “…Catalán -- 13.1 Introduction -- 13.2 Immunodetection and Legionella Fast Detection -- 13.3 Legionella Detection using Microfluidics -- 13.4 Future Research Directions -- Chapter 14: Detection of virus in the water environment / Johan Nordgren and Lennart Svensson -- 14.1 Introduction -- 14.2 Concentration of Virus from Water Samples -- 14.3 Detection and Quantification Methods -- 14.4 Perspectives -- References -- Chapter 15: Design of PCR primers for the detection of waterborne bacteria / Julien Gardès and Richard Christen -- 15.1 Introduction -- 15.2 The Target Genes -- 15.3 Design of PCR Primers -- 15.4 DNA-Based Detection Technologies -- 15.5 Conclusions -- References -- Chapter 16: Fluid structure and boundary slippage in nanoscale liquid films / Nikolai V. …”
    Libro electrónico
  11. 13771
    Tabla de Contenidos: “…Transboundary water co-operation in the Jordan River Basin -- The risks of global warming to coral reef ecosystems -- Glossary -- A new vision of open knowledge systems for sustainability: Opportunities for social scientists -- Changing the conditions of change by learning to use the future differently -- Climate is culture -- Participatory water governance in Mercosur countries -- Open knowledge and learning for sustainability -- Winning environmental justice for the Lower Mekong Basin -- Global governance and sustainable development -- Bibliometric analysis of social science research into global environmental change -- Vulnerable and resilient children after disasters and gene–environment interplay -- Migration as an adaptation strategy to environmental change -- Basic statistics on the production of social science research -- Towards greater fairness in sharing the risks and burdens of global environmental change -- Integrated Research on Disaster Risk programme -- The role of the social sciences in adapting to climate change in northern Europe -- Climate change mitigation, a problem of injustice -- The politics of climate change and grassroots demands -- The paradoxes of climate change and migration -- Regional divides in global environmental change research capacity -- Climate change education and Education for Sustainable Development -- A functional risk society? …”
    Libro electrónico
  12. 13772
    Publicado 2020
    Tabla de Contenidos: “…- Clinical and Statistical Considerations when Assessing Oxygen Levels in Tumors: Illustrative Results from Clinical EPR Oximetry Studies -- Fatal Alliance of Hypoxia-/HIF-1α-driven Microenvironmental Traits Promoting Cancer Progression -- Quantification of Tumor Oxygenation based on FMISO PET: Influence of Location and Oxygen Level of the Well-Oxygenated Reference Region -- Pathways of Oxygen Diffusion in Cells and Tissues: Hydrophobic channeling via networked lipids -- Part III Muscle Oxygenation and Sports Medicine -- Effect of Exercise Duration on Post-exercise Persistence of Oxyhemoglobin Changes in the Premotor Cortex: A Near-infrared Spectroscopy Study in Moderate-intensity Cycling Exercise -- Relationship Between Muscle Oxygen Saturation and Exercise Load in Patients with Malignant Hematopoietic Disease -- Comparison of the Effects of Continuous and Intermittent Exercise on Cerebral Oxygenation and Cognitive Function -- Relationship between Exercise Capacity and Muscle O2Hb saturation in Patients before Hematopoietic Stem-Cell Transplantation -- Differences in Muscle O2 Dynamics During Treadmill Exercise Between Aerobic Capacity-matched Overweight and Normal-weight Adults -- Cerebral Oxygenation Dynamics of the Prefrontal Cortex and Motor-Related Area During Cardiopulmonary Exercise Test: A Near-infrared Spectroscopy Study -- Reduced Optical Path Length in the Vastus Lateralis during Ramp Cycling Exercise -- Improvements in Skeletal Muscle can be Detected using Broadband NIRS in First-Time Marathon Runners -- Comparison of Two NIRS Tissue Oximeters (Moxy and Nimo) for Non-invasive Assessment of Muscle Oxygenation and Perfusion -- Part IV Cell Metabolism and Tissue Oxygenation -- Effects of Pulsed Magnetic Field on the Hemolysis of Erythrocytes Exposed to Oxidative Stress -- Role of Microtubule-associated Factors in HIF1α Nuclear Translocation -- Extracellular Acidosis Regulates the Expression of Inflammatory Mediators in Rat Epithelial Cells -- Part V Methodology of O2 Measurements -- Reducing False Alarm Rates in Neonatal Intensive Care: A New Machine Learning Approach -- Development of an IoT-based Monitoring System for Healthcare: A Preliminary Study -- Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism -- Validation and Comparison of Monte Carlo and Finite Element Method in Forward Modeling for Near Infrared Optical Tomography -- Development of a Cuff-less Blood Pressure Monitoring System and its Application -- Usefulness of a New Device to Monitor Cerebral Blood Oxygenation using NIRS during Cardiopulmonary Resuscitation in Patients with Cardiac Arrest: A Pilot Study -- Application of Peripheral Near Infrared Spectroscopy to Assess Risk Factors in Patient with Coronary Artery Disease: Part 1 -- Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-oxidase Responses to +Gz Acceleration in Healthy Volunteers -- Time-resolved NIROT ‘Pioneer’ System for Imaging Oxygenation of the Preterm Brain: Preliminary Results -- Application of Peripheral Near Infrared Spectroscopy to Assess Risk Factors in Patient with Coronary Artery Disease: Part 2 -- Optimization of Band Selection in Multispectral and Narrow-Band Imaging: An Analytical Approach -- Fabrication and Optical Characterization of Gelatin-Based Phantoms for Tissue Oximetry -- Two-Photon Autofluorescence Imaging of Fixed Tissues: Feasibility and Potential Values for Biomedical Applications -- Part VI Special Topics -- Acute Anemia Induces Erythropoiesis in Rat Organ Surface Primo-Vascular Tissue -- Analysis and Differential Expression of Primo Genes using RNA-Seq and qRT-PCR Experiments -- Acupuncture Inhibits the Increase in Alpha-synuclein in Substantia nigra in an MPTP- induced Parkinsonism Mouse Model -- On the Biomarkers of Alzheimer’s Disease -- Effective Murine Model Induction for Niche Study in Immune Cells against Leukemia -- Index…”
    Libro electrónico
  13. 13773
    Publicado 2021
    Tabla de Contenidos: “…Lehrkräftebildung neu gedacht Marcus Kubsch, Stefan Sorge, Julia Arnold & Nicole Graulich Teil I - Kompetenzen innovativ vermitteln "Design Thinking meets Didactics" - Fachdidaktische Ausbildung Chemie Hans-Dieter Körner & Andreas Belthle Einführung in Grundlagen der Forschungsmethodik in der naturwissenschaftsdidaktischen Lehrkräftebildung - Eine fachübergreifende Neuausrichtung im Sinne eines Flipped-Classroom-Konzepts Sarah Hundertmark, Benedikt Heuckmann & Julian Heeg Lehrkräftebildung an der Hochschule konstruktivistisch gestalten - Lehr-Lern-Prinzipien, -Modelle und -Settings zu Lernen mittels Konzeptwechsel, Problembasiertem und Situiertem Lernen Finja Grospietsch, Isabelle Lins, Katharina Gimbel & Monique Meier Kompetenzorientierte Lehre in physikdidaktischen Lehrveranstaltungen nach dem Inverted-Classroom-Ansatz Martin Schwichow Ein digitales Seminarkonzept zur kooperativen und differenzierten Gestaltung von inklusivem naturwissenschaftlichem Unterricht Vanessa Seremet, Katharina Gierl, Jaar Boskany, Robin Schildknecht, Alexander Kauertz, Sandra Nitz & Andreas Nehring MINTegration - Projektunterricht mit Geflüchteten Martin Lindner, Teresa Fritsch, Jette Lippmann Diagnostizieren, Fördern, Tutorieren - Ein Seminarkonzept zur Anwendung fachdidaktischer Methoden in Kooperation mit chemischen Fachmodulen Leonie Lieber, Julia Ortmann, Ira Caspari & Nicole Graulich Historische Experimente in die Lehrkräftebildung integrieren Michelle Mercier & Peter Heering Aktuelle molekularbiologische Themen in der Schule vermitteln lernen - Verzahnung von Professionswissen und explizite Thematisierung von NoS/NoSI Janne-Marie Bothor, Monique Meier, Katharina Gimbel & Kathrin Ziepprecht Die kopernikanische Wende als Anlass zur expliziten Thematisierung der Natur der Naturwissenschaften im Astronomieunterricht Inka Haak, Jens Klinghammer, Olaf Krey & Thorid Rabe "Das brauche ich nie mehr in der Schule" - Integrationsmodul Analytische Chemie Markus Emden, Hans-Dieter Körner & Matthias Scholz Innovative Kooperation mit Forschungsabteilungen aus Physik und Technik für das Lehramtsstudium - Kontextualisiertes Lernen anhand aktueller Forschungsprojekte Andrea Maria Schmid, Markus Rehm & Dorothee Brovelli Forschung trifft Schule - Chemie-Labothek als innovatives, vernetzendes Format Claudia Bohrmann-Linde, Nico Meuter, Richard Kremer, Nuno Pereira Vaz & Julian Venzlaff Lehr-Lern-Labor BinEx - Konzeption eines Lehr-Lern-Labor-Seminars zum binnendifferenzierenden Experimentieren Anita Stender Teil II - Fokus: Planung und Reflexion von Unterricht Zur softwaregestützten Förderung der unterrichtlichen Planungskompetenz in Schulpraktika - das Onlinetool "DU - Digitales Unterrichtscoaching" Daniel Scholl, Simon Küth, Björn Schwarz, Hannah Lathan, Petra Wolters & Christoph Schüle Kontrastieren und Vergleichen mit Videovignetten - Konzeption einer Diagnose-Übungseinheit für Biologielehramtsstudierende Daniel Horn & Monique Meier Fachspezifisches Classroom Management beobachten - Videovignetten als digitale Lehr-Lern-Tools Tobias Denecke, Dagmar Hilfert-Rüppell & Kerstin Höner Videobasierte Kompetenzentwicklungskette in fachdidaktischen Praktika und Seminaren - Von der Videographie mit Live-Feedback zur kollaborativen Videoanalyse Christoph Thyssen & Arash Tolou Sachcomicgestaltung mit der Paper-Cut-Out-Technik im Lehramt der Naturwissenschaften Markus Prechtl Förderung angehender Lehrkräfte im Umgang mit Evidenzen für den naturwissenschaftlichen Unterricht Pascal Pollmeier & Sabine Fechner Wie adaptiert man Unterrichtskonzepte erfolgreich? …”
    Libro electrónico
  14. 13774
    Publicado 2019
    Tabla de Contenidos: “…12.1 Silica/Diamond Nanohybrids -- 12.2 Gold/Diamond Nanohybrids -- 12.2.1 Photoluminescence Enhancement -- 12.2.2 Dual‐Modality Imaging -- 12.2.3 Hyperlocalized Hyperthermia -- 12.2.4 NV‐Based Nanothermometry -- 12.3 Silver/Diamond Nanohybrids -- 12.4 Iron Oxide/Diamond Nanohybrids -- 12.4.1 Single‐Domain Magnetization -- 12.4.2 Magnetic Resonance Imaging -- References -- Chapter 13 Nanodiamond‐Enabled Medicine -- 13.1 NDs as Therapeutic Carriers -- 13.2 Drug Delivery -- 13.2.1 Small Molecules -- 13.2.2 Proteins -- 13.3 Gene Therapy -- 13.3.1 RNA -- 13.3.2 DNA -- 13.4 Animal Experiments -- References -- Chapter 14 Diamonds in the Sky -- 14.1 Unidentified Infrared Emission -- 14.2 Extended Red Emission -- 14.3 Cosmic Events at Home on Earth -- References -- Further Reading -- Index -- EULA…”
    Libro electrónico
  15. 13775
    Publicado 2000
    Tabla de Contenidos: “…Establishment of the Role of Steroid Hormones in Plant Growth and Development -- NRI Awards -- Patents -- Publications -- Additional Information -- Signal-Transduction Pathway of the Plant Hormone Ethylene -- NRI Awards -- Patents -- Publications -- Additional Information -- Improvements in Plant Biotechnology by Manipulation of Gene Silencing -- NRI Awards to Vicki Vance, University of South Carolina -- NRI Awards to James Carrington, Texas A&amp -- M University -- Patent -- Publications -- A New BAC Library Vector for Transferring Large DNA Inserts to Plants -- NRI Award -- Patent -- Publications -- Additional Information: -- Appendix H Research Needs in Food, Fiber, and Natural Resources -- PLANTS -- ANIMALS -- NUTRITION, FOOD SAFETY, AND HEALTH -- NATURAL RESOURCES AND THE ENVIRONMENT -- ENHANCING VALUE AND USE OF AGRICULTURAL AND FOREST PRODUCTS -- MARKETS, TRADE, AND RURAL DEVELOPMENT -- Appendix I Grant Performance Follow-on for Quality Evaluation -- References -- About the Authors -- RECENT PUBLICATIONS OF THE BOARD ON AGRICULTURE AND NATURAL RESOURCES…”
    Libro electrónico
  16. 13776
    Publicado 2018
    Tabla de Contenidos: “…Borawska and Wojciech Wasowicz The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism doi: 10.3390/nu8120772 -- Tinashe Chikowore, Pedro T. …”
    Libro electrónico
  17. 13777
    Tabla de Contenidos: “…UTILITY AND LIMITATIONS OF IN VITRO STUDIES -- GENOTOXICITY AND CARCINOGENIC POTENTIAL OF POWER-FREQUENCY ELECTRIC AND MAGNETIC FIELDS -- EXPERIMENTAL STUDIES OF IN VITRO EFFECTS -- Heritable Changes in Cells Exposed In Vitro to Electric and Magnetic Fields -- Transient Changes in Cells Exposed In Vitro to Electric and Magnetic Fields -- Signal Transduction -- Gene Expression and Protein Synthesis -- Calcium Changes -- 4 Animal and Tissue Effects -- SUMMARY AND CONCLUSIONS -- CRITERIA FOR CONSIDERATION OF LITERATURE -- USE OF ANIMAL STUDIES IN EVALUATING RISK -- Types of Animal Studies Used in Descriptive Toxicology -- Acute Lethality -- Repeated-Dose Studies -- Subchronic Toxicity Studies -- Chronic Toxicity Studies -- Developmental and Reproductive Studies -- Cocarcinogenicity and Copromotion Studies of Electric and Magnetic Fields -- CARCINOGENIC AND MUTAGENIC EFFECTS -- Complete Carcinogen Studies -- Tumor-Initiation Studies -- Tumor-Promotion Studies -- REPRODUCTIVE AND DEVELOPMENTAL EFFECTS -- Nonmammalian Studies of 50- or 60-Hz Electric Fields -- Fish -- Chicken -- Mammalian Studies of 50- or 60-Hz Electric Fields -- Mice -- Rats -- Swine -- Cattle -- Nonmammalian Studies of Time-Varying Magnetic Fields -- Chicken -- Mammalian Studies of Time-Varying Magnetic Fields -- Mice -- Rats -- Summary of Reproductive and Developmental Effects -- NEUROBEHAVIORAL EFFECTS -- Electric Fields -- Magnetic Fields -- Summary of Neurobehavioral Effects -- IN VIVO NEUROCHEMICAL AND NEUROENDOCRINE EFFECTS -- Neurochemical Effects -- Melatonin Effects -- Effects of Electric Fields on Animals -- Effects of Magnetic Fields on Animals -- Effects of Combined Electric and Magnetic Fields on Animals -- Effects of Electric and Magnetic Fields on Humans -- Neuroendocrine Effects -- Consistency and Plausibility of Results -- BONE HEALING AND STIMULATED CELL GROWTH…”
    Libro electrónico
  18. 13778
    Publicado 1930
    Libro
  19. 13779
    Publicado 2016
    “…Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. …”
    Libro electrónico
  20. 13780
    Publicado 2012
    “…The purpose of this book is to introduce a variety of methods and tools to isolate and identify unknown bacteria through biochemical and molecular differences, based on characteristic gene sequences. Furthermore, molecular tools involving DNA sequencing, and biochemical tools based in enzymatic reactions and proteins reactivity, will serve to identify genetically modified organisms in agriculture, as well as for food preservation and healthcare, and improvement through natural products utilization, vaccination and prophylactic treatments, and drugs testing in medical trials…”
    Libro electrónico