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  1. 7181
    por Leurs, Koen
    Publicado 2024
    Tabla de Contenidos: “…Photo by Yener Bayramoğlu. -- Figure 9.3. A defaced sticker on a lamppost in Kreuzberg, Berlin, 2021. …”
    Libro electrónico
  2. 7182
    Publicado 2023
    Tabla de Contenidos: “…Cover -- Title Page -- Copyright and Credits -- Dedications -- Foreword -- Contributors -- Table of Contents -- Preface -- Part 1: Introduction to Detectron2 -- Chapter 1: An Introduction to Detectron2 and Computer Vision Tasks -- Technical requirements -- Computer vision tasks -- Object detection -- Instance segmentation -- Keypoint detection -- Semantic segmentation -- Panoptic segmentation -- An introduction to Detectron2 and its architecture -- Introducing Detectron2 -- Detectron2 architecture -- Detectron2 development environments -- Cloud development environment for Detectron2 applications -- Local development environment for Detectron2 applications -- Connecting Google Colab to a local development environment -- Summary -- Chapter 2: Developing Computer Vision Applications Using Existing Detectron2 Models -- Technical requirements -- Introduction to Detectron2's Model Zoo -- Developing an object detection application -- Getting the configuration file -- Getting a predictor -- Performing inferences -- Visualizing the results -- Developing an instance segmentation application -- Selecting a configuration file -- Getting a predictor -- Performing inferences -- Visualizing the results -- Developing a keypoint detection application -- Selecting a configuration file -- Getting a predictor -- Performing inferences -- Visualizing the results -- Developing a panoptic segmentation application -- Selecting a configuration file -- Getting a predictor -- Performing inferences -- Visualizing the results -- Developing a semantic segmentation application -- Selecting a configuration file and getting a predictor -- Performing inferences -- Visualizing the results -- Putting it all together -- Getting a predictor -- Performing inferences -- Visualizing the results -- Performing a computer vision task -- Summary…”
    Libro electrónico
  3. 7183
    Publicado 2013
    Tabla de Contenidos: “…Summary -- Introduction -- 1.1 Protein aggregation and amyloidoses -- 1.1.1 Mechanisms of amyloid fibril formation -- 1.1.2 Oligomer structural polymorphism: fibrillar and prefibrillar oligomers -- 1.1.3 Oligomer toxicity: common mechanism of pathogenesis -- 1.1.4 Amyloid formation is an inherent property of polypeptide chains: functional amyloid and disease unreleated amyloid -- 1.2 HypF-N: model protein of amyloid aggregation unrelated to disease -- 1.2.1 Function, structure and aggregation of HypF-N -- 1.2.2 HypF-N protofibrils interact with cell membranes originating a cytotoxic cascade -- 1.2.3 A causative link between the structure of HypF-N oligomers and their ability to cause cellular dysfunction -- 1.3 Alzheimer's disease -- 1.3.1 The Alzheimer phenotype -- 1.3.2 The elaborate processing of APP -- 1.3.3 The genetics of Alzheimer's disease -- 1.3.4 Peripheral cells as a tool to identify and test hypotheses on AD pathophysiology -- 1.3.5 Adult neurogenesis and stem cell technology for AD -- 1.4 Cholesterol and gangliosides in the central nervous system (CNS) -- 1.4.1 Brain cholesterol metabolism -- 1.4.2 Ganglioside metabolism -- 1.4.3 Lipid rafts -- 1.4.4 Role of cholesterol in AD -- 1.4.5 Role of gangliosides in AD -- 1.5 Aim of the study -- Materials & Methods -- 2.1 Materials -- 2.1.1 Chemicals -- 2.1.2 Fluorescent probes -- 2.1.3 Peptides and aggregation protocols -- 2.2 Cell cultures -- 2.3 Methods -- 2.3.1 Separation processes -- 2.3.2 Differentiation of human mesenchymal stromal cells -- 2.3.3 Modulation of membrane cholesterol levels -- 2.3.4 Modulation of membrane GM1 levels -- 2.3.5 Cholesterol content measurements -- 2.3.6 GM1 content measurements -- 2.3.7 Cell exposure to peptide aggregates -- 2.3.8 Analysis of aggregate interaction with the cells -- 2.3.9 Analysis of aggregate interaction with GM1 -- 2.3.10 Analysis of aggregate internalisation -- 2.3.11 Analysis of membrane permeability -- 2.3.12 Analysis of cytosolic Ca2+ dyshomeostasis -- 2.3.13 Evaluation of ROS production -- 2.3.14 Analysis of lipid peroxidation -- 2.3.15 Cytotoxicity assay and cell death analysis: apoptotic and necrotic markers -- 2.3.16 Steady-state fluorescence anisotropy -- 2.3.17 Atomic force microscopy (AFM) -- 2.3.18 Measurements of the fluorescence intensities -- 2.3.19 Statistical analysis -- Results -- 3.1 Results I -- 3.1.1 A protective role for lipid raft cholesterol against amyloidinduced membrane damage in human neuroblastoma cells -- 3.1.2 Aß42 oligomer binding to the cell surface and its cytotoxic effect are modulated by membrane cholesterol content -- 3.1.3 Aß42 oligomers colocalize with lipid rafts -- 3.1.4 Isolation and characterization of DRMs -- 3.1.5 Effects of ADDLs on lipid raft structural order -- 3.1.6 AFM imaging of supported DRMs purified from cells exposed to ADDLs -- 3.2 Results II -- 3.2.1 Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease -- 3.2.2 Lipid rafts are primary interaction sites for Aß42 oligomers at the plasma membrane -- 3.2.3 Cholesterol and GM1 mediate Aß42 accumulation at the plasma membrane -- 3.2.4 Cholesterol and GM1 mediate Ca2+ dyshomeostasis and extensive membrane permeabilization induced by Aß42 oligomers -- 3.2.5 GM1 modulates lipid peroxidation and cytotoxicity induced by Aß42 oligomers -- 3.2.6 GM1 mediates Aß42-induced Ca2+ dyshomeostasis, lipid peroxidation and cytotoxicity in rat cortical neurons -- 3.3 Results III -- 3.3.1 Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers -- 3.3.2 Membrane cholesterol content modulates oligomer cytotoxicity -- 3.3.3 Membrane cholesterol modulates oligomer-induced alteration of intracellular Ca2+ homeostasis and ROS levels -- 3.3.4 Cholesterol levels modulate membrane permeability to the oligomers -- 3.3.5 Membrane GM1 affects the cytotoxic and permeabilizing effects of HypF-N oligomers -- 3.3.6 GM1, rather than cholesterol, plays a dominant role in oligomer cytotoxicity and membrane permeability -- 3.4 Results IV -- 3.4.1 Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aß42 aggregate toxicity -- 3.4.2 Neuronal differentiation of hMSCs results in reduced levels of membrane GM1 -- 3.4.3 Neuronal differentiation of hMSCs reduces the interaction of Aß42 oligomers with the cell surface -- 3.4.4 Neuronal differentiation of hMSCs reduces Aß42 oligomerinduced intracellular Ca2+ dyshomeostasis and oxidative stress -- 3.4.5 Neuronal differentiation of hMSCs increases cell resistance to Aß42 aggregates Discussion -- 4.1 A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells -- 4.2 Lipid rafts mediate amyloid-induced calcium dyshomeostasis and membrane permeabilization in Alzheimer's fibroblasts -- 4.3 Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers -- 4.4 Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aß42 aggregate toxicity -- 4.5 Concluding remarks -- Abbreviations -- References…”
    Libro electrónico
  4. 7184
    Publicado 2011
    Libro
  5. 7185
    Publicado 1947
    Tabla de Contenidos: “…Una inscripció de Sant Joan de la Penya / per Miquel Dolç. Permanence de la peinture de style gothique français en Catalogne et Languedoc, dans la seconde moitié du XIVe siècle / per Marcel Durliat. …”
    Libro
  6. 7186
    Publicado 1947
    Tabla de Contenidos: “…Una inscripció de Sant Joan de la Penya / per Miquel Dolç. Permanence de la peinture de style gothique français en Catalogne et Languedoc, dans la seconde moitié du XIVe siècle / per Marcel Durliat. …”
    991004128899706719
  7. 7187
    Publicado 2024
    Tabla de Contenidos: “…Cover -- Title page -- Copyright and Credits -- Contributors -- Table of Contents -- Preface -- Part 1: Recent Developments in the Field, Installations, and Hello World Applications -- Chapter 1: From Bag-of-Words to the Transformers -- Evolution of NLP approaches -- Recalling traditional NLP approaches -- Language modeling and generation -- Leveraging DL -- Considering the word order with RNN models -- LSTMs and gated recurrent units -- Contextual word embeddings and TL -- Overview of the Transformer architecture -- Attention mechanism -- Multi-head attention mechanisms -- Using TL with Transformers -- Multimodal learning -- Summary -- References -- Chapter 2: A Hands-On Introduction to the Subject -- Technical requirements -- Installing transformer with Anaconda -- Installation on Linux -- Installation on Windows -- Installation on macOS -- Installing TensorFlow, PyTorch, and Transformer -- Installing and using Google Colab -- Working with language models and tokenizers -- Working with community-provided models -- Working with multimodal transformers -- Working with benchmarks and datasets -- Important benchmarks -- GLUE benchmark -- SuperGLUE benchmark -- XTREME benchmark -- XGLUE benchmark -- SQuAD benchmark -- Accessing the datasets with an application programming interface -- Data manipulation using the datasets library -- Sorting, indexing, and shuffling -- Caching and reusability -- Dataset filter and map function -- Processing data with the map function -- Working with local files -- Preparing a dataset for model training -- Benchmarking for speed and memory -- Summary -- Part 2: Transformer Models: From Autoencoders to Autoregressive Models -- Chapter 3: Autoencoding Language Models -- Technical requirements -- BERT - one of the autoencoding language models -- BERT language model pretraining tasks…”
    Libro electrónico
  8. 7188
  9. 7189
    Publicado 1987
    Libro
  10. 7190
    Publicado 2000
    Libro
  11. 7191
    por Maestre Brotons, Antoni
    Publicado 2006
    Libro
  12. 7192
    Publicado 2023
    Libro
  13. 7193
    Publicado 2022
    Tabla de Contenidos: “…Bibliografía -- Referencias bibliográficas básicas -- Referencias bibliográficas citadas -- 2 Morfología, David Serrano-Dolader y Bárbara Marqueta -- 2.1. Introducción -- 2.2. …”
    Libro electrónico
  14. 7194
    Publicado 2022
    Tabla de Contenidos: “…Artificial intelligence (AI) as a solace to help mankind out…”
    Libro electrónico
  15. 7195
    Publicado 2018
    Libro
  16. 7196
    Publicado 2019
    Tabla de Contenidos: “…-- 3.4.2 CONCEPTOS FUNDAMENTALES DE LA FILOSOFÍA BUDISTA -- EVALUACIÓN -- 3.5 REPERCUSIONES DEL BUDISMO EN EL MUNDO ACTUAL -- 3.5.1 ¿UNA ESPIRITUALIDAD INCULTURADA O UN SELFST MADE RELIGION? -- 3.5.2 EL DALAI LAMA, VÍA Y CARA DEL BUDISMO EN EL MUNDO OCCIDENTAL ACTUAL -- CONCLUSIÓN -- EVALUACIÓN -- REFERENCIAS -- CAPÍTULO 4 JUDAÍSMO -- 4.1 HISTORIA: ORIGEN Y DESARROLLO -- 4.1.1 ORIGEN -- 4.1.2 MOMENTOS CRUCIALES DEL DESARROLLO -- EVALUACIÓN -- 4.2 DOCTRINA: LA TORÁ -- 4.2.1 NATURALEZA Y CONTENIDO GENERAL DE LA TORÁ -- 4.2.2 ELEMENTOS DOCTRINALES ESPECÍFICOS DE LA TORÁ -- EVALUACIÓN -- 4.3 RITOS Y FIESTAS DEL JUDAISMO -- 4.3.1 CLASIFICACIÓN GENERAL A) FIESTAS -- 4.3.2 SHABAT, YOM KIPPUR Y PASH (PASO, PASCUA) -- 4.3.3 RITO DEL BAR MITZVAH -- EVALUACIÓN -- 4.4 REPERCUSIONES DEL JUDAÍSMO EN EL MUNDO ACTUAL…”
    Libro electrónico
  17. 7197
    Publicado 2023
    Tabla de Contenidos: “…Cover -- Title Page -- Copyright and Credits -- Foreword -- Acknowledgements -- Table of Contents -- Preface -- Part 1: I, for One, Welcome our New Quantum Overlords -- Chapter 1: Foundations of Quantum Computing -- Quantum computing: the big picture -- The basics of the quantum circuit model -- Working with one qubit and the Bloch sphere -- What is a qubit? -- Dirac notation and inner products -- One-qubit quantum gates -- The Bloch sphere and rotations -- Hello, quantum world! …”
    Libro electrónico
  18. 7198
    por García Martín, Josep Miquel
    Publicado 2000
    Libro
  19. 7199
    por Epalza, Mikel de, 1938-2008
    Publicado 2003
    Libro
  20. 7200
    Publicado 2017
    Tesis