“…In this regard, cannabidiol has gained interest because of its potential therapeutic properties, in line with evidence that CBD and Δ9-THC may exhibit opposite effects at the cannabinoid receptor type 1 (CB1), Δ9-THC being a partial agonist and CBD an antagonist/inverse agonist. …”

“…High-throughput screening protocols, mainly based on classical mechanics’ atomistic potentials, are largely employed in biology and medicinal chemistry studies with the aim of simulating drug-likeness and bioactivity in terms of efficient binding to the target receptors. The advantages of this approach are quick outcomes, the possibility of repurposing commercially available drugs, consolidated protocols, and the availability of large databases. …”

“…O livro trata do funcionamento da sinalização purinérgica em condições fisiológicas gerais e sobre a história das enzimas e dos receptores purinérgicos. Aborda situações fisiológicas, como a modulação do sistema purinérgico pelo exercício físico e por moléculas nutracêuticas. …”

“…T and B cells recognizing alloantigens via specific receptors become activated and undergo proliferation and differentiation into different types of effector and memory cells. …”

“…The manufacturer submitted a cost-utility analysis of ivabradine as an add-on therapy to standard of care (SOC) compared with SOC alone, which includes an angiotensin-converting enzyme inhibitor (ACEI) (or an angiotensin receptor blocker [ARB] if the ACEI is not tolerated), a beta-blocker, and/or a mineralocorticoid receptor antagonist. …”

“…Tumor associated carbohydrate antigens can be coupled covalently to protein carriers to target MHC receptors and improve immunogenicity and have reached already pre-clinical and clinical studies. …”

“…In general, the specialised field Radiopharmaceutical Chemistry focusses on the development, synthesis and radiolabelling of aforementioned "food," such as small molecules, biotechnology-derived antibodies or (cyclised) (oligo)peptides which are used to address clinically relevant biological "downstream" targets such as receptors, enzymes, transport systems and others. Addressing "upstream" targets such as DNA- and RNA-fragments using corresponding radioactive substrates represents a further feasible strategy. …”

“…The microscopic scale refers to those processes that occur at the subcellular level, such as DNA synthesis and duplication, gene dynamics, activation of receptors, transduction of chemical signals, diffusion of ions and transport of proteins. …”
Acceso restringido con credenciales, usuarios UPSA

“…Se han reportado polimorfismos en genes de receptores que intervienen en Ia interacción del Iipopolisacárido bacteriano con la célula de Kupffer, LPB Y CD14, asi como en el factor transcripcional NFkB; moléculas proinflamatorias, TNF-Ot, IL-1, R-IL-1, IL-6 e lL-8; factores de crecimiento, Tor-B y PDGF; las enzimas metabolizadoras de etanol ADH, ALDH y CYP2E1; y en sistemas eliminadores de sustancias reactivas de oxígeno, como MnSOD. …”
Acceso restringido con credenciales UPSA

“…Es decir, elegir entre ser «receptores » o ser «donantes».<br /><br /> Dar y recibir te descubrirá la clave del éxito de quienes se vuelcan en los demás y cambiará para siempre tus percepciones sobre el triunfo y el fracaso. …”
Texto completo en Odilo

“…Se han reportado polimorfismos en genes de receptores que intervienen en Ia interacción del Iipopolisacárido bacteriano con la célula de Kupffer, LPB Y CD14, asi como en el factor transcripcional NFkB; moléculas proinflamatorias, TNF-Ot, IL-1, R-IL-1, IL-6 e lL-8; factores de crecimiento, Tor-B y PDGF; las enzimas metabolizadoras de etanol ADH, ALDH y CYP2E1; y en sistemas eliminadores de sustancias reactivas de oxígeno, como MnSOD. …”
Enlace del recurso

“…Las migraciones constituyen un fenómeno social complejo, característico de nuestras sociedades actuales, que está directamente relacionado con los procesos de desarrollo de los países emisores y receptores. Los vínculos entre las migraciones y el desarrollo son innegables, pero también complejos, y no es posible establecer una única relación de causa-efecto entre la migración y sus consecuencias en el progreso de las comunidades y de los países de donde proceden las personas migrantes. …”

“…The microscopic scale refers to those processes that occur at the subcellular level, such as DNA synthesis and duplication, gene dynamics, activation of receptors, transduction of chemical signals, diffusion of ions and transport of proteins. …”

“…For example the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, organ-on-a-chip, etc. in understanding the mechanisms of toxicity and the regulation of chemicals…”

“…On the other hand, the discovery of new members of the Ig superfamily ligand, VISTA; the intriguing role of modulatory molecules like Retinoic Acid, Neuropilin-1, Fc gamma receptors, or cytokines such as IL-33, among others, are revealing new possibilities in the development of new strategies to conquer our obsession: immune tolerance. …”

“…In this Research Topic, our purpose is to compile the latest developments in our understanding of molecular and cellular mechanisms underlying pre- and postsynaptic assembly, specification of synaptic adhesion pathways, presynaptic neurotransmitter release and postsynaptic receptor trafficking. In addition, non-neuronal cell processes involved in dismantling and eliminating synapses and relevant neural circuits will be covered. …”

“…La méthode d'essai EASZY (Endocrine Active Substances using Zebrafish embrYos) est une méthode de dépistage in vivo de type mécanistique, conçue pour détecter les perturbateurs endocriniens agissant comme agonistes des récepteurs des œstrogènes (estrogen receptors, ER), en induisant l'expression de la protéine fluorescente verte (Green Fluorescent Protein, GFP) sous le contrôle du promoteur du gène cyp19a1b. …”

“…Aquesta investigació pretén abordar la qualitat dels serveis esportius municipals, contrastant les percepcions que d'ells tenen els planificadors, els gestors i els receptors, basant-se en dimensions i indicadors comuns en tots ells, pretenent poder comparar entre diferents municipis, sigui quina sigui la seva dimensió, característiques, etc. …”
Accés lliure

“…This chapter includes phytochrome, as well as the blue and UV light receptors and their signaling pathways, including phototropins, cryptochromes, and UVR8. …”
Material d'acompanyament

“…Discute la presencia e importancia del texto literario en la escena, y las relaciones con los receptores, como auditorio de la representación como lectores solitarios del texto dramático. …”