“…What you will learn Create a wide range of applications using various modern React tools and frameworks Discover how React Hooks modernize state management for React apps Develop progressive web applications using React components Build test-driven React applications using the Jest and Enzyme frameworks Understand full stack development using React, Apollo, and GraphQL Perform server-side rendering using React and React Router Design gestures and animations for a cross-platform game using React Native Who this book is for The book is for JavaScript developers who want to explore React tooling and frameworks for building cross-platform applications. …”

“…Aberrant DGK function has been recently associated with pathological states, an expected consequence of the essential role of these enzymes in the regulation of multiple tissue and systemic functions. …”

“…This is accomplished through a precise balance of production and degradation of a-melanocyte-stimulating hormone, an anorexigenic neuropeptide which is degraded to an inactive form unable to inhibit food intake by the key enzyme prolyl carboxypeptidase (PRCP), thus suggesting that pharmacologic approaches targeting PRCP may provide a novel and effective option for the management of obesity and its associated metabolic disorders. …”

“…Mutations in the rpfC or rpfF genes produce a reduction in enzymes and extracellular polysaccharides production, biofilm formation and pathogenicity in comparison with the respective wild type strains. …”
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“…Secretomics may help to contribute to the global food security and to the ecosystem sustainability by addressing issues in i) plant biosecurity, with the design of crops resistant to pathogens, ii) crop yield enhancement, for example driven by arbuscular mycorrhizal fungi helping plant hosts utilise phosphate from the soil hence increase biomass, and iii) renewable energy, through the identification of microbial enzymes able to augment the bio-conversion of plant lignocellulosic materials for the production of second generation biofuels that do not compete with food production. …”

“…That glutamate is synthesized in astrocytes because they in contrast to neurons express the enzyme pyruvate carboxylase was demonstrated 10-15 years later by Yu et al. in cultured astrocytes and Shank et al. in intact brain tissue. …”

“…Indeed, the repertoire of substrates for these enzymes covers a wide variety of proteins known to play important role in the neuroplastic phenomena (e.g. …”

“…The manufacturer submitted a cost-utility analysis of ivabradine as an add-on therapy to standard of care (SOC) compared with SOC alone, which includes an angiotensin-converting enzyme inhibitor (ACEI) (or an angiotensin receptor blocker [ARB] if the ACEI is not tolerated), a beta-blocker, and/or a mineralocorticoid receptor antagonist. …”

“…Reactive oxygen species (ROS) are free radical-containing oxygen molecules derived from cellular oxidative metabolism, including enzyme activities and mitochondrial respiration, and play a pivotal role in many cellular functions. …”

“…In general, the specialised field Radiopharmaceutical Chemistry focusses on the development, synthesis and radiolabelling of aforementioned "food," such as small molecules, biotechnology-derived antibodies or (cyclised) (oligo)peptides which are used to address clinically relevant biological "downstream" targets such as receptors, enzymes, transport systems and others. Addressing "upstream" targets such as DNA- and RNA-fragments using corresponding radioactive substrates represents a further feasible strategy. …”

“…Postulated mechanisms behind these metabolic, neuro-humoral, hemodynamics, and systemic adaptations include stimulation of nitric oxide synthase, increase in anti-oxidant enzymes, and down-regulation of pro-inflammatory cytokines, although the amount of evidence is not yet significant enough. …”