Tabla de Contenidos: “…Amplificación génica en carcinoma no microcítico de pulmón --3 Oncogenes activadores marcadores tumorales: el gen kras --4. …”
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“…There have been many advancements in the diagnosis and treatment of bladder cancer, one of the most common carcinomas seen in urology. As such, it is of the utmost importance for urologists and oncologists to have comprehensive and proper knowledge of the disease's diagnostic pathways as well options for its treatment. …”

“…Together with the finding that vinyl chloride increases the risk for liver cirrhosis, a risk factor for hepatocellular carcinoma, other results provide "sufficient evidence" in humans that vinyl chloride causes angiosarcoma of the liver and hepatocellular carcinoma, leading to the overall classification of vinyl chloride as "carcinogenic to humans" (Group 1). …”

“…The consequences of sarcopenia in frailty are treated in relation to other associated pathologies or lesions, as femoral neck fractures and hepatocellular carcinoma…”

“…Lo que hoy llamamos «crecimiento» es en realidad la consecuencia de un aumento excesivo de carcinomas que destruyen el organismo social. Estos tumores metastatizan sin cesar y se multiplican con una vitalidad inexplicable y mortal. …”

“…Finalmente, utilizamos un modelo más complejo, con el cocultivo de células de un carcinoma ductal in situ de mama humano y fibroblastos inflamatorios de artritis reumática. …”
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“…Experimental, pre-clinical and clinical research addressing the following aspects is included in this Research Topic: 1) Investigation of specific molecular patterns of thyroid tumorigenesis, which could allow the development of new directions in the field of pharmacotherapy research; 2) Emphasis on animal studies (preclinical models of human anaplastic thyroid cancers) for the validation of biomarkers with the potential to lead to clinical trials, and studies of targetable mechanisms of oncogenesis, progression of these malignancies, tumor microenvironment and extracellular matrix, and metastatic disease; 3) Assessment of biomarkers to predict the potential response or resistance to drug treatment (targeted cancer therapies) or to guide the follow-up of treated patients; 4) Investigation of new laboratory molecular tests (e.g. molecular techniques and applications of thyroid fine-needle aspiration biopsy) to translate in the clinical practice; In summary, specific areas of interest include: thyroid cancer genetics; genome-wide analysis; clinical and translational research; orthotopic mouse models of metastatic thyroid carcinoma; tumor microenvironment; epigenetic; biological insights of personalized medicine; novel applications of bioinformatics; large scale molecular characterization of tumors; diagnostic or prognostic biomarkers; endocrine pathology studies; thyroid fine-needle aspiration…”

“…According to the estimation from IARC, the incidence of nasopharyngeal carcinoma and liver cancer is the world’s highest in specific regions of China. …”

“…In addition, recently discovered the ubiquitin receptor protein SPRTN is part of the DNA replication machinery and its mutations cause early-onset hepatocellular carcinoma and premature ageing in humans. Despite more than 700 different enzymes directly involved in ubiquitination and sumoylation processes only few of them are known to play a role in DDR. …”