“…In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. …”

“…Besides the autoimmune phenotype of chronic inflammatory rheumatoid disorders a plethora of pathologies have been associated with defects in genes involved in clearance, e.g. atherosclerosis, cancer, gout, diabetes, some forms of blindness, neuropathy, schizophrenia and Alzheimer’s disease…”

“… - Tu cerebro puede fallar: cómo prevenir o retrasar enfermedades como el Alzhéimer, el ictus, la epilepsia o la depresión. …”

“…Clearly, there is a need of further experimental models and approaches to discern the importance of such mechanisms and to discover the factors that determine the selective death of motor neurons characteristic of ALS, in contrast to other neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Whereas studies in vitro in cell cultures, tissue slices or organotypic preparations can give useful information regarding cellular and molecular mechanisms, the experiments in living animal models obviously reflect more closely the situation in the human disease, provided that the symptoms and their development during time mimics as close as possible those of the human disease. …”

“…See how broken genes cause cancer Meet the body’s “genetic repairmen”—and understand what happens when they fail The growing price of the modern lifestyle Why one-third of all Westerners have obesity, Type 2 diabetes, or other signs of “metabolic syndrome” The Alzheimer’s generation Why some of us are predisposed to dementia What’s really normal: the deepest lessons of the human genome The remarkable diversity of physical and emotional “normality”…”

“…As such, HSP70s, in cooperation with their J-domain co-chaperones and nucleotide exchange factors (NEFs) and co-disaggregases, form an efficient network of cellular defenses against the accumulation of cytotoxic misfolded protein conformers, which may cause degenerative diseases such as Parkinson's and Alzheimer's disease, diabetes, and aging in general. …”

“…Considering the multiple cell signaling functions of these channels, their dysregulation is proposed not only as potential pathological biomarker, but it has been implicated in the pathogenesis and progression of diverse brain diseases (e.g., meningitis, Alzheimer’s disease and stroke). The aim of this Research Topic is to gather a collection of original research articles, method, protocols, short communications, opinions, perspectives, as well as review articles, providing the latest progress and insights in the field of connexin hemichannels and pannexons in the nervous system. …”

“…The possible interdependence between different cognitive systems has implications for healthy as well as pathological profiles, and in fact, work in recent years has also explored the role of ‘embodiment’ and/or the MNS in clinical populations such as stroke, Parkinson’s Disease, Alzheimer’s Disease, and Autism, among others. Research on embodiment and/or the MNS has been approached with a number of different methodologies, but the results obtained with these different methodologies have not been entirely consistent, generating doubts regarding the theories. …”

“…Less combined multiuse spaces, greater variation and less crowding resulted in less cognitive stress, depression and social isolation amongst Alzheimers patients. Single rooms with the opportunity for individual and home-like character, personal furnishing and objects resulted in less psychiatric symptoms. …”

“…Desde su dilatada experiencia investigadora, Adolf Tobeña pone a nuestra disposición los conocimientos científicos actuales sobre el envejecimiento y nos explica cuáles son las pautas de desgaste cerebral; por qué en algunas regiones del mundo hay superabundancia de personas centenarias; cuánto incide en la calidad de la vejez una determinada alimentación o qué coste comportan ciertos hábitos; hasta qué punto es relevante la llamada «suerte biológica» que nuestros progenitores nos legan en herencia; en qué consisten exactamente, y cómo se desarrollan, algunos males asociados al envejecer (como el alzhéimer) y su panorama médico y farmacológico; en fin, cuán decisivo resulta mantener la lucidez a toda costa y ejercitarla a diario. …”
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“…Interestingly, in comparison with other interneuronal types, CR+ interneurons seem to be less compromised in schizophrenia, major depression, Alzheimer disease and multiple sclerosis. The situation was found to be more complex in various epileptic conditions. …”

“…Por ejemplo, técnicas de diagnóstico por imagen, esclerosis múltiple, aminas biógenas neurotransmisoras y trastornos psiquiátricos, esclerosis lateral amiotrófica, enfermedades por priones, psicocirugía, epilepsia o la enfermedad de Alzheimer. Estudia en profundidad temas de gran interés y actualidad, como canales y transportadores iónicos, neurotransmisores y receptores, señalamiento molecular en el interior de las neuronas, plasticidad de las sinapsis, la memoria, o la sexualidad y el encéfalo. …”

“…This sets the scene for then discussing a range of different disorders including Alzheimer’s, Parkinson’s, Huntington’s disease and amyotrophic lateral sclerosis. …”

“…This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. …”

“…., perceiving music, experiencing music emotionally, playing or singing) affected by a developmental or acquired neurological illness or disorder (for example, stroke, aphasia, brain injury, Alzheimer’s disease, Parkinson’s disease, autism, ADHD, dyslexia, focal dystonia, or tinnitus) and 2) what is the applicability, effectiveness, and mechanisms of music-based rehabilitation methods for persons with a neurological illness or disorder? …”

“…This Research Topic calls for contributions on brain network of subjects in normal aging or with age-related diseases like mild cognitive impairment and Alzheimer’s disease. The studies are expected to be based on neuroimaging techniques including but not limited to functional magnetic resonance imaging, Electroencephalography, and diffusion tensor imaging, and contributions on the influence of interventions to brain networks in aging are highly encouraged. …”

“…Articles in this volume relate novel clinical solutions for a host of neurological and psychiatric conditions such as stroke, Parkinson’s disease, Huntington’s disease, epilepsy, dementia, Alzheimer’s disease, autism spectrum disorders (ASD), traumatic brain injury, and disorders of consciousness. …”

“…Aquí encontramos temáticas como la aceptación del uso de la robótica y las entrevistas holográficas en la gerontología social; Los Bancos del Tiempo como entidades de participación social y mejora en la calidad de vida de las personas mayores; la Terapia asistida con Perros y las personas mayores; La sobrecarga del cuidador informal, en referencia al Servicio de Ayuda a Domicilio; La personalización de los dormitorios en los espacios residenciales; Las viviendas colaborativas o cohousing en el ámbito de la gerontología; Mediación en Centros de Mayores; El impacto emocional generado por la COVID-19 en las personas mayores residentes y no residentes; la influencia de los aspectos socioeconómicos en la Jubilación; El clima en los Centros Gerontológicos residenciales: los conflictos entre residentes y la figura del Trabajador Social como agente de resolución de conflictos; el duelo en residencias de personas mayores; Relación entre el Alzheimer y la depresión en personas mayores de 65 años institucionalizadas; el fenómeno de la soledad en personas mayores; o la gestión de la diversidad sexual en centros gerontológicos…”