Tabla de Contenidos: “…Trajectories of the Seine River Basin -- The evolution of the Seine basin water bodies through historical maps -- Pluri-annual water budget on the Seine basin: past, current and future trends -- The Seine watershed water-agro-food system: long-term trajectories of C, N, P metabolism -- Past and future trajectories of human excreta management systems – the case of Paris 19th-21st centuries -- How agricultural practices should be integrated to understand and simulate long-term pesticide contamination in the Seine River basin? …”