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Tabla de Contenidos: “…Abstract -- Introduction -- 1.1 Ion channels and life -- 1.2 Ion channels properties -- 1.3 Ion channels as drug targets -- 1.4 The Patch-Clamp technique -- 1.5 The Cut-Open Voltage Clamp Fluorometry technique (COVCF) -- References -- Structural rearrangements of the cardiac Na+/Ca2+ Exchanger (NCX1) revealed by Cut-Open Voltage Clamp Fluorometry -- 2.1 Function and Topology of NCX1: State of the Art -- 2.2 Fluorometric measurements of conformational changes in NCX1 -- 2.3 Methods -- 2.4 Results -- 2.5 Discussion -- References -- Calcium Sensitivity of the human BKCa channel: the Role of Loop aG - ßG in the RCK1 domain -- 3.1 BKCa channels and Physiology -- 3.2 Structure of BKCa channel -- 3.3 Ca2+ sensitivity of BKCa channel -- 3.4 Methods -- 3.5 Results -- 3.6 Discussion -- References -- Blockade of hERG K+ channel by two novel quinazoline antimalarial drugs -- 4.1 Drugs, Arrhythmia and the hERG K+ channel -- 4.2 Methods -- 4.3 Results -- References -- The antimigraine compound Parthenolide, contained in the Tanacetum Parthenium, activates and desensitizes the TRPA1 channel -- 5.1 TRP channels -- 5.2 TRPA1 channel and Pain -- 5.3 Parthenolide as a natural analgesic product -- 5.4 Methods -- 5.5 Results -- References -- Acknowledgements…”

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Materias:

Materias:

Materias:

“…., potentiometry, impedance spectrometry, and patch-clamp electrophysiology). Irrespective of the method of choice, “bioelectric profiling” is being rapidly established as a superior concept for a number of applications, including in vitro toxicity, signal transduction, real-time medical diagnostics, environmental risk assessment, and drug development. …”

Tabla de Contenidos: “…Los canales iónicos y su modulación por el voltaje; 4.1 Registro de canales únicos en parches de membrana (patch clamp); 4.2 Canales iónicos sensibles a voltaje y excitabilidad celular; 4.3 Reconstrucción del potencial de acción; 4.4 Estructura molecular de los canales iónicos; 4.5 Canalopatías; 5. …”