Tabla de Contenidos: “…Epidemiology of gynecologic cancers -- Clinical genetics of gynecologic cancer -- The biology of gynecologic cancer -- Tumor invasion, angiogenesis, and metastasis: biology and clinical application -- Oncogenes and tumor suppressor genes -- Immunotherapy of gynecologic malignancies -- Development and identification of tumor markers -- Cancer prevention strategies -- Clinical trials methodology and biostatistics -- Diagnostic imaging techniques in gynecologic oncology -- Perioperative and critical care -- Surgical principles in gynecologic oncology -- Laparoscopic surgery in gynecologic cancer -- Biologic and physical aspects of radiation oncology -- Principles of chemotherapy in gynecologic cancer -- Pharmacology and therapeutics in gynecologic cancer -- Hormones and human malignancies -- Innovative 21st century therapies -- Pathogenesis and diagnosis of preinvasive lesions of the lower genital tract -- Vulva -- Vagina -- Uterine cervix -- Corpus: epithelial tumors -- Corpus: mesenchymal tumors -- Epithelial ovarian cancer -- Ovarian germ cell tumors -- Ovarian sex cord-stromal tumors -- Molar pregnancy and gestational trophoblastic neoplasms -- Breast cancer -- Management of infections in patients with gynecolgoic malignancy -- Management of complications of gynecologic cancer treatment -- Management of pain -- Nutrition support of patients with gynecologic cancer -- Quality of life issues in gynecologic oncology -- End of life care…”
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Tabla de Contenidos: “…Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling -- Live-single-cell phenotypic cancer biomarkers-future role in precision oncology? …”

Tabla de Contenidos: “…Adenovector-mediated cancer gene therapy / Efficacy, toxicity, and immunogenicity of adenoviral vectors / Lentiviral and retroviral vector systems / Vaccinia and pox-virus / Herpes simplex virus as a therapy for cancer / Alphavirus vectors for gene therapy applications / Vesicular stomatitis virus and RNA viruses as gene therapy vectors / Parvovirus vectors / Nonviral vector systems / Oncogenes, tumor suppressor genes, and apoptosis-inducing genes utilized in cancer gene therapy / Gene silencing therapy against cancer / Tumor targeting-retargeted adenovirus / Oncolytic herpes simplex for gene therapy in preclinical and clinical trials / Cytokine gene therapy for genitourinary cancer / Combination of gene therapy with radiation…”

Tabla de Contenidos: “…Oral Cancer around Dental Implants: Are the Clinical Manifestations and the Oncogenic Mechanisms Unique? -- 7. Variability of Saliva Viscosity Potential Impact. -- 8. …”

Tabla de Contenidos: “…METHYL BROMIDE RISK CHARACTERIZATION IN CALIFORNIA -- Copyright -- Preface -- Contents -- Executive Summary -- THE SUBCOMMITTEE'S TASK -- THE SUBCOMMITTEE'S EVALUATION -- Toxicology -- Recommendations -- Exposure -- Recommendations -- Risk Characterization -- Recommendations -- 1 Introduction -- BACKGROUND -- CALIFORNIA REGULATIONS -- THE SUBCOMMITTEE'S TASK -- ORGANIZATION OF THE REPORT -- 2 Toxicology and Hazard Identification -- PHARMACOKINETICS -- GENOTOXICITY -- ACUTE TOXICITY -- SUBCHRONIC TOXICITY -- CHRONIC INHALATION AND ONCOGENICITY -- REPRODUCTIVE TOXICITY -- DEVELOPMENTAL TOXICITY -- NEUROTOXICITY -- SELECTION OF CRITICAL EFFECTS FOR ACUTE TOXICITY -- 3 Exposure Assessment -- BACKGROUND -- LIKELY EXPOSURE SCENARIOS -- QUALITY OF DATA AVAILABLE FOR CHARACTERIZING EXPOSURES -- Analytical Methods -- Representativeness of Available Exposure Measurements -- Appropriateness of Normalizing Assumptions for Different Application Rates -- Appropriateness of Exposure-Duration Assumptions -- ACCURACY AND APPROPRIATENESS OF AVAILABLE MODELING TOOLS -- Exposure Estimates Based on Modeling -- Exposure of Residents in a Fumigated House -- Exposure of Residents Downwind from Soil Fumigations -- SUMMARY -- 4 Risk Characterization -- RISK CHARACTERIZATION GOALS -- HAZARD IDENTIFICATION -- Acute Toxicity Database -- Subchronic Toxicity Database -- Chronic Toxicity Database -- Developmental Neurotoxicity -- EXPOSURE ASSESSMENT -- Appropriateness of Acute-Exposure Definition -- Subchronic Exposure -- Chronic Exposure -- MARGIN-OF-EXPOSURE ANALYSIS -- Categories with More than Two Data Points -- Categories with One or Two Data Points -- UNCERTAINTY ISSUES -- Derivation of Reference Concentrations -- Sensitive Subpopulations -- Multiple Exposures -- SUMMARY -- 5 Conclusions and Recommendations -- TOXICOLOGICAL INFORMATION -- Conclusions -- Recommendations…”

“…Asimismo, la expresión de oncogenes en los tumores, sería un factor determinante en la efectividad del tratamiento…”
Enlace del recurso

Tabla de Contenidos: “…GENÉTICA Y CÁNCER; INTRODUCCIÓN; CARACTERÍSTICAS DEL CÁNCER; CARCINOGÉNESIS; INICIACIÓN, PROMOCIÓN Y PROGRESIÓN; ANGIOGÉNESIS TUMORAL; ONCOGENES; ASPECTOS CLÍNICOS…”

Tabla de Contenidos: “…Prostate cancer cell growth and death : complex roles of pro- and anti-oncogenic protein signaling / Qun Lu ... [et al.] -- Key role of bone microenvironment on prostate cancer bone metastasis : the tumor sanctuary and source of prostate cancer cell survival, migration, and development in bone / Mori, K. ... …”

Tabla de Contenidos: “…Factores asociados con el desarrollo del cáncer -- 1.2.1. Oncogenes -- 1.2.2. Genes supresores de tumores -- 1.2.3. …”

Tabla de Contenidos: “…Contraception -- George Seldes leads the fight to deal with tobacco-related illness -- Penicillin -- The Development of surgical anesthesia -- Blood transfusion -- Modern surgical techniques -- The Control of Polio -- Cardiac catheterization and related techniques -- Cholesterol and the metabolic basis of cardiovascular disease -- Lab rats tango in the Bronx - The Development of radioimmunoassay -- The Discovery of viruses -- Retroviruses and oncogenes -- Koch's postulates -- Victory at C and the concept of vitamins -- Carbolic acid wound dressing -- Dentistry -- The Relaxing factor that led to viagra -- Advanced imaging techniques -- Immunological tolerance and rejection -- Solid organ transplantation -- Kidney transplantation -- Liver transplantation - Heart transplantation -- Bone marrow transplantation -- Ancient and early surgery -- The Development of medical subspecialties -- The Development of surgical subspecialties -- Minimally invasive surgery -- Birthing care -- Hospitals -- Coronary care and other intensive care units -- Streptomycin and control of tuberculosis -- Digitalis -- The Pneumococcus from hell and understanding antibiotic resistance -- The Development of antiviral drugs and cures for childhood leukemia -- Chemotherapy for malignant disease -- Therapeutic radiation -- Rita Levi-Montalcini discovers nerve growth factor -- Hemodialysis -- Restoration of vision with cataract and retinal surgery -- Understanding retroviruses and the treatment of AIDS -- The Polymerase chain reaction (PCR) -- The Human genome project -- Gene therapy --…”

Tabla de Contenidos: “….] -- Assessment of RET/PTC oncogene activation in thyroid nodules utilizing laser microdissection followed by nested RT-PCR / Giovanni Tallini and Guilherme Brandao -- Combined laser-assisted microdissection and short tandem repeat analysis for detection of in situ microchimerism after solid organ transplantation / Ulrich Lehmann, Anne Versmold, and Hans Kreipe -- Laser-assisted microdissection of membrane-mounted tissue sections / Lise Mette Gjerdrum and Stephen Hamilton-Dutoit -- Laser-assisted microdissection of membrane-mounted sections following immunohistochemistry and in situ hybridization / Lise Mette Gjerdrum and Stephen Hamilton-Dutoit -- Laser-assisted cell microdissection using the palm system / Patrick Micke ... …”

Tabla de Contenidos: “…Balmain, United Kingdom -- Oncogene function in normal development and disease by E. …”

Tabla de Contenidos: “…Oral Contraceptives &amp -- Breast Cancer -- Copyright -- Preface -- Contents -- Executive Summary -- MAINTAINING SURVEILLANCE -- DEVELOPING A BROADER ARRAY OF CONTRACEPTIVES -- ASSESSING KNOWLEDGE FOR APPLICATION IN CLINICAL PRACTICE -- FILLING GAPS IN BIOLOGICAL AND EPIDEMIOLOGICAL KNOWLEDGE -- 1 Introduction and Overview -- BIOLOGICAL PLAUSIBILITY OF A LINK BETWEEN ORAL CONTRACEPTIVES AND BREAST CANCER -- WHAT IS-AND IS NOT-KNOWN -- SEEKING ANSWERS -- 2 Epidemiology: Information Needs and Data Gaps -- EPIDEMIOLOGICAL RESEARCH -- Case-Control Method -- Cohort Studies -- Comparison Groups -- Ecological Studies -- Special Studies -- Women Exposed to Hormones Other than Oral Contraceptives -- Women Genetically Susceptible to Breast Cancer -- Estrogen Metabolism -- Progestins -- Changing Oral Contraceptive Formulations -- SUMMARY AND CONCLUSIONS -- 3 Biology: Information Needs and Data Gaps -- SIGNAL COMPLEXITY IN BREAST REGULATION -- RESEARCH ISSUES -- Relationships Among Cell Types -- Receptors -- Timing -- Effects of Pregnancy and Lactation -- Pathological Breast Tissue -- Oncogenes -- Molecular Changes Associated with Human Breast Cancer -- Activated ras Mutations -- Overexpression of Tyrosine Kinases -- Amplification of int-2 and myc -- Deletions of Genes -- RESEARCH MODELS -- Breast Cancer Cell Lines -- Short-term Culture of Normal Mammary Epithelium -- Organ Culture -- Nude Mouse Model -- SUMMARY AND CONCLUSIONS -- 4 Information for Users of the Pill and Health Care Providers -- BENEFITS AND RISKS OF ORAL CONTRACEPTIVES -- Benefits -- Risks -- CURRENT CONTROVERSY -- PRESCRIBING PROBLEMS -- 5 Policy Issues and Recommendations -- MAINTAINING SURVEILLANCE -- Cooperative Research -- Surveillance Requirements of the Food and Drug Administration -- DEVELOPING A BROADER ARRAY OF CONTRACEPTIVES…”

Tabla de Contenidos: “…Contaminación ambiental; 4.2.3. Biotoxinas; 4.2.4. Oncogenes y oncoproteínas; 5. PERSPECTIVAS; 6. REFERENCIAS; 3 VIRUS EN MOLUSCOS ; 1. …”

Tabla de Contenidos: “…DNA Fingerprinting -- Nucleic Acid Hybridization -- Putting Classification Methods Together -- Study Outline -- Study Questions -- 11 The Prokaryotes: Domains Bacteria and Archaea -- The Prokaryotic Groups -- DOMAIN BACTERIA -- Gram-Negative Bacteria -- Proteobacteria -- The Nonproteobacteria Gram-Negative Bacteria -- The Gram-Positive Bacteria -- Firmicutes (Low G + C Gram-Positive Bacteria) -- Tenericutes -- Actinobacteria (High G + C Gram-Positive Bacteria) -- DOMAIN ARCHAEA -- Diversity within the Archaea -- MICROBIAL DIVERSITY -- Discoveries Illustrating the Range of Diversity -- Study Outline -- Study Questions -- 12 The Eukaryotes: Fungi, Algae, Protozoa, and Helminths -- Fungi -- Characteristics of Fungi -- Medically Important Fungi -- Fungal Diseases -- Economic Effects of Fungi -- Lichens -- Algae -- Characteristics of Algae -- Selected Phyla of Algae -- Roles of Algae in Nature -- Protozoa -- Characteristics of Protozoa -- Medically Important Protozoa -- Slime Molds -- Helminths -- Characteristics of Helminths -- Platyhelminths -- Nematodes -- Arthropods as Vectors -- Study Outline -- Study Questions -- 13 Viruses, Viroids, and Prions -- General Characteristics of Viruses -- Host Range -- Viral Size -- Viral Structure -- Nucleic Acid -- Capsid and Envelope -- General Morphology -- Taxonomy of Viruses -- Isolation, Cultivation, and Identification of Viruses -- Growing Bacteriophages in the Laboratory -- Growing Animal Viruses in the Laboratory -- Viral Identification -- Viral Multiplication -- Multiplication of Bacteriophages -- Multiplication of Animal Viruses -- Viruses and Cancer -- The Transformation of Normal Cells into Tumor Cells -- DNA Oncogenic Viruses -- RNA Oncogenic Viruses -- Viruses to Treat Cancer -- Latent Viral Infections -- Persistent Viral Infections -- Plant Viruses and Viroids -- Prions -- Study Outline…”

Tabla de Contenidos: “…4.2 Mutaciones genéticas y alteraciones epigenéticas asociadas al cáncer; 4.2.1 Protooncogenes y oncogenes; 4.2.2 Genes supresores de tumor; 4.2.3 Genes de reparación del ADN; 4.2.4 Metastogenes y genes supresores de la metástasis; 4.3 Alteraciones epigéneticas; 4.4 Predisposición genética a desarrollar cáncer; 4.5 Papel del microambiente en el cáncer; 4.6 Todavía falta mucho por conocer; 5. …”

Tabla de Contenidos: “…MicroRNA-199b Deregulation Shows Oncogenic Properties and Promising Clinical Value as Circulating Marker in Locally Advanced Rectal Cancer Patients Reprinted from: Int. …”

Tabla de Contenidos: “…Recombination Repair -- SOS Repair/Error-Prone Repair -- Oncogenes -- Summary -- Review Questions -- References -- Chapter 9: Recombinant DNA Technology -- Introduction -- DNA Isolation and Sequencing -- Tools of Recombinant DNA Technology -- Restriction Endonucleases -- Types of Restriction Endonucleases -- Nomenclature of Restriction Endonuclease -- Type II Restriction Endonucleases -- Producing rDNA by Sticky-End Ligation -- Producing rDNA by Blunt-End Ligation -- Homopolymer Tailing -- Other Enzymes Used in rDNA Technology -- S1 Nuclease -- DNA Pol-I, Klenow Fragment -- Alkaline Phosphatase -- Reverse Transcriptase -- Deoxyribonuclease I (DNAse I) -- Cloning Vectors -- Types of Cloning Vectors -- Cosmid Vectors -- Shuttle Vectors -- Yeast Episomal Plasmids -- YAC Vectors -- Vectors for Plants -- Genes of Ti Plasmid and their Function -- Nucleic Acid Hybridization and Probes -- Nick Translation -- End Labelling or End Filling -- Non-radioactive Labelling -- Fluorescein Labelling -- Enzyme Labels -- Advantages of non-radioactive Labels -- In Situ Hybridization -- Fluorescent in Situ Hybridization (FISH) -- Molecular Cloning -- Preparation of Vector DNA -- Preparation of Target DNA -- Construction of rDNA -- Transport into the Host Cell (Transfection) -- Selection of Transformed Cells -- Construction of C-DNA and Genomic Libraries -- Genomic Library -- Applications of Recombinant DNA Technology -- In Pharmaceutical Industry -- Construction of Industrially Important Bacteria -- Summary -- Review Questions -- References -- Chapter 10: Epigenetics -- Introduction -- Heterochromatin and Histone Interactions -- Telomeric Silencing -- Polycomb and Trithorax -- CpG Islands -- Genomic Imprinting -- Epigenetic Effects and Inheritance -- The Epigenetic Inheritance of X Chromosomes -- Prions -- Summary -- Review Questions -- References…”

“…Tumor cells commonly exhibit dependence on a single activated oncogenic pathway or protein to maintain their malignant proliferation and survival, a phenomenon called "oncogene addiction". …”

“…Areas of interest include, but are not limited to, the structure, expression, or function of genes or gene products associated with normal growth and differentiation and alterations in neoplasia; characterization of genes or gene products expressed in preneoplastic or neoplastic cells; molecular studies that define a specific function of a tumor-associated protein or its effects on cellular function; virtually all research on molecular aspects of oncogenes, tumor suppressor genes, and their gene products; carcinogenesis studies in transgenic mice; and research on human tumor viruses…”