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Tabla de Contenidos: “…Regulating Pesticides in Food -- Copyright -- Preface -- Acknowledgments -- Contents -- REGULATING PESTICIDES IN FOOD -- Executive Summary -- THE COMMITTEE'S ESTIMATES OF ONCOGENIC RISK -- ESTIMATED ONCOGENIC RISK AND ITS DISTRIBUTION IN THE FOOD SUPPLY -- Findings -- IMPACTS OF FOUR ALTERNATIVE WAYS TO REGULATE ONCOGENIC RESIDUES -- Results of the Scenarios -- Findings -- AN ANALYSIS OF THE FUNGICIDES: A SPECIAL CASE -- PESTICIDE INNOVATION AND ALTERNATIVE PEST-CONTROL METHODS -- Alternative Technologies -- The Effect of the Delaney Clause on R&amp -- D -- The Minor Use Issue -- The Delaney Clause and Pest Resistance -- MAJOR CONCLUSIONS AND RECOMMENDATIONS -- Legal Basis for Regulation -- A Nonzero Standard for Oncogenic Risk -- Targeting High-Risk Pesticide and Crop Uses -- The Adoption of an Analytical Framework -- 1 Introduction -- FIFRA AND THE FDC ACT -- THE DELANEY CLAUSE AND THE PURPOSE OF THIS REPORT -- THE COMMITTEE'S TASKS -- NOTES -- 2 The Current System: Theory and Practice -- REGISTRATION OF PESTICIDES UNDER FIFRA -- TOLERANCE SETTING UNDER THE FDC ACT -- Section 408-The Statutory Standard -- Section 409 -- The Tolerance-Setting Process Under Sections 408 and 409 -- Overview of the Process -- Specific Data Requirements -- Oncogenicity and Carcinogenicity -- Tolerance Setting for Non-Oncogenic Pesticides Under Section 408 -- Tolerance Setting for Oncogenic Compounds Under Section 408 -- Tolerance Setting Under Section 409 -- THE DATA CALL-IN PROGRAM -- THE DELANEY CLAUSE-A CLOSER EXAMINATION -- SUMMARY OF PROBLEMS AND ISSUES POSED BY THE DELANEY CLAUSE -- Inconsistency -- The Issue of Concentration in Processed Foods -- Paradoxical Regulatory Results -- NOTES -- 3 Estimates of Dietary Oncogenic Risks -- INTRODUCTION -- Pesticide Use Patterns in the United States -- Pesticide Use Data -- Problems in Estimating Current Risk…”

Tabla de Contenidos: “…Origins and beginnings -- From literature to medicine to science -- The first taste of scientific success -- Retroviruses and their replication cycle -- The RSV oncogene and its progenitor -- How proto-oncogenes participate in cancer -- Targeted therapies for human cancers -- Partnerships in science -- The road to Building One -- Being NIH director -- Priority setting -- Bad times and good times as NIH director -- Embryos, cloning, stem cells, and the promise of reprogramming -- Global science and global health -- Science publishing and science libraries in the Internet age…”

Tabla de Contenidos: “…. -- CONCEPTUALIZACIÓN TEÓRICA DE LA PRUEBA -- TRANSMISIÓN DE SEÑALES BIOQÚMICAS -- BASE GENÉTICA DEL CÁNCER: ONCOGENES Y GENES SUPRESORES -- ONCOGEN C-ERBB-2 (HER-2/NEU O HER 2) -- CONCLUSIÓN Y RECOMENDACIONES -- BIBLIOGRAFIA…”

Tabla de Contenidos: “…Origins in the dark -- Redefining viruses -- On the fringes -- From cell culture to the molecular revolution -- Medical virology in the Netherlands after 1950 -- Techniques and instruments -- Dutch virology in the tropics -- From cancer mice in the roaring 1920s to oncogenes and signalling molecules in the booming 1990s -- Virus vaccines and immunization programmes…”

Tabla de Contenidos: “…Head Neck Squamous Cell Cancer Genomics: Oncogenes, Tumor Suppressor Genes and Clinical Implications -- 4. …”

Tabla de Contenidos: “…DNA structure and stability : mutations versus repair -- Regulation of gene expression -- Growth factor signaling and oncogenes -- The cell cycle -- Growth inhibition and tumor suppressor genes -- Apoptosis -- Stem cells and differentiation -- Metastasis -- Infections and inflammation -- Nutrients, hormones, and gene interactions -- The cancer industry : drug development and clinical trial design -- Cancer in the future : focus on diagnostics and immunotherapy…”

Tabla de Contenidos: “…The biology and genetics of cells and organisms -- The nature of cancer -- Tumor viruses -- Cellular oncogenes -- Growth factors and their receptors -- Cytoplasmic signaling circuitry programs many of the traits of cancer -- Tumor suppressor genes -- pRb and control of the cell cycle clock -- p53 and apoptosis: master guardian and executioner -- Eternal life: cell immortalization and tumorigenesis -- Multistep tumorigenesis -- Maintenance of genomic integrity and the development of cancer -- Dialogue replaces monologue: heterotypic interactions and the biology of angiogenesis -- Moving out: invasion and metastasis -- Crowd control: tumor immunology and immunotherapy -- The rational treatment of cancer…”

Tabla de Contenidos: “…Dualistic Typing of Epithelial Ovarian Cancers: Emerging Paradigms for Oncogenic Progression and Cancer Treatment; 4. Genomic Analysis of Epithelial Ovarian Cancer; 5. …”

Tabla de Contenidos: “…DESCUBRIMIENTO DE LOS PRIMEROS ONCOGENESEN LOS RETROVIRUS4. CONCEPTO DE ONCOGÉN; 5. CLASIFICACIÓN DE LOS ONCOGENES; 6. ACTIVACIÓN DE LOS ONCOGENES; 6.1. …”

Tabla de Contenidos: “…Cells and macromolecules -- Protein structure -- Properties of nucleic acids -- Prokaryotic and eukaryotic chromosome structure -- DNA replication -- DNA damage, repair and recombination -- Gene manipulation -- Cloning vectors -- Gene libraries and screening -- Analysis and uses of cloned DNA -- Transcription in prokaryotes -- Regulation of transcription in prokaryotes -- Transcription in eukaryotes -- Regulation of transcription in eukaryotes -- RNA processing and RNPs -- The genetic code and tRNA -- Protein synthesis -- Bacteriophages and eukaryotic viruses -- Tumor viruses and oncogenes -- Functional genomics and new technologies -- Bioinformatics…”

Tabla de Contenidos: “…BIOLOGÍA MOLECULAR DEL CÁNCER; INTRODUCCIÓN; ONCOGENES VIRALES Y ONCOGENES CELULARES; AGENTES MUTAGÉNICOS; EL CÁNCER Y LA HERENCIA; ONCOGENES Y GENES SUPRESORES DE TUMORES…”

Tabla de Contenidos: “…. -- Malfunction of signaling pathways and tumorigenesis: oncogenes and tumor suppressor genes. -- Apoptosis…”

Tabla de Contenidos: “…Historia de la investigación en cáncer; 2.1 Cinco teorías; 2.2 La causa de la transformación neoplásica; 2.2.1 La teoría viral; 2.2.1.1 En nuestro laboratorio: en busca del virus oncogénico humano; 2.2.2 La teoría del oncogen; 2.2.2.1 HTLV (virus de la leucemia T humana); 2.2.2.2 HIV y cáncer; 2.2.3 La teoría del anti-oncogen o genes supresores de tumor; 2.2.4 La teoría génica o cascada de mutaciones somáticas; 2.2.5 La teoría de la inflamación…”

Tabla de Contenidos: “…Clasificación de los oncogenes --6. Activación de los oncogenes --7. Proteínas codificadas por oncogenes --8. …”
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