Tabla de Contenidos: “…Cerebral Angioplasticity: The Anatomical Contribution to Ensuring Appropriate Oxygen Transport to Brain -- Changes in Cytochrome-C-Oxidase Account for Changes in Attenuation of Near-Infrared Light in the Healthy Infant Brain -- Hyperspectral Imaging of the Hemodynamic and Metabolic States of the Exposed Cortex: Investigating a Commercial Snapshot Solution -- Impact of Aging on Metabolic Changes in the Ketotic Rat Brain: Glucose, Oxidative and 4-HNE Metabolism -- Increases in Microvascular Perfusion and Tissue Oxygenation via Vasodilatation after Anodal Transcranial Direct Current Stimulation in the Healthy and Traumatized Mouse Brain -- Fluctuations of Nutrition-associated Markers After Decompressive Hemicraniectomy in Middle Cerebral Artery Occlusion Patients -- Resuscitation Fluid with Drag Reducing Polymer Enhances Cerebral Microcirculation and Tissue Oxygenation after Traumatic Brain Injury Complicated by Hemorrhagic Shock -- Comparison of Quantitative and Qualitative Oxygen Extraction Fraction (OEF) in Acute Stroke Patients with Large Vessel Occlusion -- Relation Between Asymmetry of Prefrontal Activity and Autonomic Nervous System in Post-stroke Patients with a Disorder of Consciousness -- Cerebral Hemodynamics after Transcranial Direct Current Stimulation (tDCS) in Patients with Consequences of Traumatic Brain Injury -- Differences in Tissue Oxygenation, Perfusion and Optical Properties in Brain Areas Affected by Stroke: A Time-resolved NIRS Study -- Changes of Doublecortin-immunoreactive Cells from the Acute Phase to Chronic Phase after Transient Global Brain Ischemia in Rat Cingulate Cortex -- Post-resuscitation Arterial Blood Pressure on Survival and Change of Capillary Density following Cardiac Arrest and Resuscitation in Rats -- Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study -- Effects of Aerobic Cycling Training on O2 Dynamics in Several Leg Muscles in Early Post-Myocardial Infarction -- Evaluation of Functional Hyperemia using NIRTRS without the Influence of Fat Layer Thickness -- Changes in Spinal Muscle Oxygenation and Perfusion during the Biering-Sørensen Test: Preliminary Results of a Study Employing NIRS-based Muscle Oximetry -- Near Infrared Spectroscopy (NIRS) Observation of Vastus Lateralis (muscle) and Prefrontal Cortex (brain) Tissue Oxygenation during Synchronised Swimming Routines in Elite Athletes -- Impact of Changes in Systemic Physiology on fNIRS/NIRS Signals: Analysis Based on Oblique Subspace Projections Decomposition -- Changes in Cerebral Oxyhaemoglobin Levels During and After a Single 20-minute Bout of Moderate-intensity Cycling -- Changes in the Prefrontal Cortex Oxygenation Levels during Cycling in the Supine and Upright Positions -- Trail Making Test Induces Prefrontal Cortex Activation as Revealed by a cw Wearable-Wireless fNIRS/DOT Imager -- Prediction of MMSE Score Using Time-resolved Near-infrared Spectroscopy -- Broadband NIRS Cerebral Cytochrome-C-Oxidase Response to Anoxia Before and After Hypoxic-Ischaemic Injury in Piglets -- Synchronized Oscillations of Arterial Oxygen Saturation, Cerebral Tissue Oxygenation and Heart Rate in Preterm Neonates: Investigation of Long-Term Measurements with Multiple Einstein’s Cross Wavelet Analysis -- Multispectral Near-Infrared Optical Tomography for Cancer Hypoxia Study in Mice -- Hypoxia-/HIF-1α-Driven Factors of the Tumor Microenvironment Impeding Antitumor Immune Responses and Promoting Malignant Progression -- Differential Expression of PGC1α in Intratumor Redox Subpopulations of Breast Cancer -- Accounting for Two Forms of Hypoxia for Predicting Tumour Control Probability in Radiotherapy: An In Silico Study -- Impact of Temporal Heterogeneity of Acute Hypoxia on the Radiation Response of Experimental Tumors -- Mathematical Description of Changes in Tumour Oxygenation from Repeated Functional Imaging -- An In Vitro Model for Determining Tumor Cell Migration Under Metabolic Gradients -- Expression of MicroRNAs in Fibroblasts and Macrophages Is Regulated by Hypoxia-Induced Extracellular Acidosis -- Influence of Extracellular Acidosis on Matrix Protein Homeostasis in Tumour Cells and Fibroblasts -- Novel Redox Active Tyrosine Mutations Enhance the Regeneration of Functional Oxyhemoglobin from Methemoglobin: Implications for Design of Blood Substitutes -- Septic-induced microRNA Expression Modulations are linked to Angiogenesis, Vasomotion, and Hypoxia-induced Processes -- Guidance to Transfer ‘Bench-ready’ Medical Technology into Usual Clinical Practice - Case Study: Sensors and Spectrometer used in EPR Oximetry -- Regulation of Oxygen Tension in the Mammalian Retina During Systemic Hyperoxia is Species Dependent -- Intravital Observation of Microvascular Remodeling during Chronic Exposure to Hypoxia in Mice -- Analysis of Aortic Remodeling and Stiffness in Patients with Obstructive Sleep Apnea Syndrome: Preliminary Results -- Does Vascular Endothelial Cell or Smooth Muscle affect the Decrease in Oxygen Consumption of Arteriolar Wall during Vasodilation -- Hyperbaric Oxygen Therapy in Necrotizing Soft Tissue Infections: A Retrospective Study -- Dynamic Exercise Elicits Dissociated Changes between Tissue Oxygenation and Cerebral Blood Flow in the Prefrontal Cortex: A Study using NIRS and PET -- Mucine-1 is Related to Cell-Mediated Immunoexpression and Blood Pressure in Pulmonary Artery in Pulmonary Arterial Hypertension (PAH): Preliminary Results -- The Mitochondrial Na+/Ca2+ Exchanger is Necessary but not Sufficient for Ca2+ Homeostasis and Viability -- Hemoglobin Dynamics in the Skeletal Muscle of Patients with Malignant Hematopoietic Disease -- Fatigue, Muscle Oxygen Consumption and Blood Flow to the Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation -- Reliability of Wearable Two Channel CW-NIRS in Measurements of Brain Function -- Investigation of Confounding Factors in Measuring Tissue Saturation with NIRS Spatially Resolved Spectroscopy -- Discrimination of Complex Activation Patterns in Near Infrared Optical Tomography with Artificial Neural Networks -- ABroAD: A Machine Learning Based Approach to Detect Broadband NIRS Artefacts -- Absolute Values of Optical Properties (μa, μs', μeff and DPF) of Human Head Yissue: Dependence on Head Region and Individual -- Long-term Changes in Optical Properties (μa, μs', μeff and DPF) of Human Head Tissue during Functional Neuroimaging Experiments -- A Fibreless Multiwavelength NIRS System for Imaging Localised Changes in Cerebral Oxidised Cytochrome C Oxidase -- Use of a Turn Coil and Channel above a GMR-SV Device to Observe and Measure the Properties of Deoxidized Red Blood Cells Coupled to Magnetic Beads -- Long-term in vivo Oxygen Sensors for Peripheral Artery Disease Monitoring -- A New Method Based on Virtual Fluence Detectors and Software Toolbox for Handheld Spectral Optoacoustic Tomography -- Computerized Video-capillaroscopy Alteration Related to Diabetes Mellitus and its Complications -- Contrast Ratio Quantification during Visualization of Microvasculature -- In vitro Comparisons of Near-Infrared Spectroscopy Oximeters: Impact of Slow Changes in Scattering of Liquid Phantoms -- Liquid Blood Phantoms to Validate NIRS Oximeters: Yeast versus Nitrogen for Deoxygenation -- Visualization of Methemoglobin Distribution in Tissues: Phantom Validation -- Polyunsaturated Fatty Acids induce ROS Synthesis in Microvascular Endothelial Cells -- Effect of Chain Unsaturation and Temperature on Oxygen Diffusion through Lipid Membranes from Simulations -- Reduced Oxygen Permeability upon Protein Incorporation within Phospholipid Bilayers -- Sanal-Cell Cycle and Primo Vascular System: Regeneration via Sanals -- Role of CXCR4 antagonist in Megakaryocyte Reinstatement with Increased Sinusoidal Vessel Density -- Solid-phase Extraction with Packed-Fiber is a Biological Sample Preparation Tool for Neuro-active Molecule Detection -- Salivary Alpha-amylase and Behavior Reaction in Acute Stress and the Impact of Tridimensional Personality…”

Tabla de Contenidos: “…Health Promotion and Disease Prevention in Old Age -- Studies of Geriatric Syndromes -- Failure to Thrive (Inanition) -- Impaired Postural Stability, Strength, and Mobility -- Mismanagement of Medications -- Urinary Incontinence -- Delirium -- Cardiovascular Disease -- Dementia, Pseudodementia, and Psychiatric Disorders -- Musculoskeletal Disorders -- Infectious Disease and Immunosenescence -- Neoplasia -- Disorders of Metabolism and Homeostasis -- ADDITIONAL RESEARCH OPPORTUNITIES -- RESOURCE RECOMMENDATIONS -- CROSSCUTTING ISSUES -- REFERENCES -- 4 Behavioral and Social Sciences -- JUSTIFICATION AND MAJOR THEMES -- The Dynamic Interaction of Individuals and Sociocultural Contexts -- Differentiation -- Modifiability -- RESEARCH PRIORITIES -- ADDITIONAL RESEARCH OPPORTUNITIES -- METHODOLOGICAL NEEDS -- Tests and Instruments -- Coordination of Large-Scale Research -- Field Intervention Studies -- RESOURCE RECOMMENDATIONS -- CROSS-DISCIPLINARY AND CROSSCUTTING ISSUES -- Gender -- Race and Ethnicity, Socioeconomic Status, and Other Cultural Factors -- Population Dynamics -- Brain, Environment, Society, and Behavior -- REFERENCES -- 5 Health Services Delivery Research -- LONG-TERM CARE AND CONTINUITY OF CARE FOR OLDER PERSONS -- Characteristics of Older Persons Requiring Long-Term Care -- Informal Providers of Long-Term Care -- Formal Long-Term Care -- Supply of Personnel for Long-Term Care -- Locus of Long-Term Care -- Quality Assurance -- Technologies -- FINANCING OF HEALTH CARE FOR OLDER PERSONS -- DRUG USE -- Inappropriate Prescribing -- Noncompliance -- Drug Costs and Older Persons -- MENTAL HEALTH SERVICES -- DISABILITY/DISEASE PREVENTION AND HEALTH PROMOTION SERVICES -- RESEARCH PRIORITIES -- ADDITIONAL RESEARCH OPPORTUNITIES -- RESOURCES REQUIRED -- CROSS-DISCIPLINARY AND CROSSCUTTING ISSUES -- REFERENCES -- 6 Research in Biomedical Ethics…”

Tabla de Contenidos: “…2.2 MEDIO INTERNO Y HOMEOSTASIS2.3 MOVIMIENTO DE AGUA Y DE SOLUTOS A TRAVES DE LOS EPITELIOS Y ENTRE LOS COMPARTIMIENTOS INTRA Y EXTRACELULAR; - Mecanismos por los cuales se mueven el agua y los solutos.; Difusión; - Flujo unidireccional y flujo neto; - Ley de Fick.; - Viaje de un ion en el agua extracelular Imaginemos un ion Na+ en el agua plasmática, dentro de un capilar.; - Consecuencias de un flujo difusional; DIFUSION FACILITADA:; - Consecuencias de la presencia de transportadores: inhibición competitiva y no competitlva.; Filtración; - Volumen molar parcial del agua ( V )…”

Tabla de Contenidos: “…TRÁNSITO DESDE LO FENOMENOLÓGICO HASTA LO FENOMÉNICO -- LA MUERTE COMO TEMPORALIDAD -- HEURÍSTICA DE LA EPOJÉ DESDE EL RECONOCIMIENTO DE UNA HOMEOSTASIS PARA UN TIEMPO-SER -- NIVELES PRIMARIOS EPISTÉMICOS DE LA MUERTE ANTE LA VIDA O NACIMIENTO -- EXÉGESIS DIALÉCTICO-DOCTRINAL DE LA MUERTE. …”

Tabla de Contenidos: “…Agents Affecting Mineral Ion Homeostasis and Bone Turnover -- Section VI: Drugs Affecting Gastrointestinal Function -- 45. …”

“…En consecuencia, mejora la salud mental, entendida como una homeostasis (equilibrio) corporal y mental. El zen es una forma de vivir la vida, una norma de conducta, llegando a conocer sin pretender conocer, llegando a comprender sin pretender comprender, llegando a aprehender sin pretenderlo. …”

“…Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. …”

Tabla de Contenidos: “…-Los mecanismos de regulación y la homeostasis de los geosistemas.; 9.2- La resiliencia y la estabilidad de los paisajes:; 9.3.…”

Tabla de Contenidos: “…INTRODUCCIÓN; 2.2. CONCEPTO DE HOMEOSTASIS…”

“…Un aspecto fundamental que hay que considerar en la enfermedad critica es la homeostasis endocrina, de la que depende un sinnumero de vias de senalizacion intracelulares e intercelulares que se traducen en la sincronizacion de funciones metabolicas y organicas…”

“…The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. …”

Tabla de Contenidos: “…Consciousness, Emotional Self-Regulation and the Brain -- Editorial page -- Title page -- LCC page -- Table of contents -- List of contributors -- Introduction -- Overview of chapter contents -- Acknowledgements -- Emotion self-regulation -- Introduction -- Components of emotion -- Gross' process model of emotion self-regulation -- Theoretical and empirical challenges in measuring antecedent emotion self-regulation -- Izard's multi-system model of emotion generation -- Implications of Izard's multi-system model of emotion activation for emotion self-regulation -- Emotion self-regulation and emotional homeostasis -- A sequential model of emotion self-regulation -- Control regulation -- Emotional dissociation -- Enhancing and suppressing emotional expression -- Anticipatory regulation -- Exploratory regulation -- Emotion self-regulation as a contextually-bound process -- Summary and future research directions -- References -- Temperament and emotional regulation -- Introduction -- Theoretical and empirical approaches to emotional regulation -- Emotional regulation in early childhood: Normative development -- Temperament and early emotional development -- Temperament and the development of emotional regulation -- Direct effects of temperament -- Moderated effects of temperament -- Mediational effects of temperament -- Future directions in the study of temperament and emotional regulation -- Summary -- Acknowledgements -- References -- Emotion dysregulation and psychopathology -- Introduction -- Functionalist theory -- Emotion regulation and dysregulation -- What gets regulated in emotion regulation? …”

Tabla de Contenidos: “…DISTRIBUCIÓN DEL AGUA EN EL CUERPO -- 1.3. LA DESEADA HOMEOSTASIS HÍDRICO-ELECTROLÍTICA -- 1.4. INGRESOS DE AGUA -- 1.5. …”

Tabla de Contenidos: “…Intro -- Cover -- Title Page -- Copyright Page -- Preface -- Acknowledgments -- Contents -- Chapter 1 THE HUMAN BODY: AN ORIENTATION -- An Overview of Anatomy and Physiology -- Levels of Structural Organization -- Maintaining Life -- Homeostasis -- The Language of Anatomy -- At the Clinic -- The Finale: Multiple Choice -- Chapter 2 BASIC CHEMISTRY -- Concepts of Matter and Energy -- Composition of Matter -- Molecules, Chemical Bonds, and Chemical Reactions -- Biochemistry: The Composition of Living Matter -- Incredible Journey: A Visualization Exercise for Biochemistry -- At the Clinic -- The Finale: Multiple Choice -- Chapter 3 CELLS AND TISSUES -- Cells -- Overview -- Anatomy of a Generalized Cell -- Cell Physiology -- Body Tissues -- Tissue Repair -- Developmental Aspects of Cells and Tissues -- Incredible Journey: A Visualization Exercise for the Cell -- At the Clinic -- The Finale: Multiple Choice -- Chapter 4 SKIN AND BODY MEMBRANES -- Classification of Body Membranes -- Integumentary System (Skin) -- Basic Functions of the Skin -- Basic Structure of the Skin -- Appendages of the Skin -- Homeostatic Imbalances of the Skin -- Developmental Aspects of the Skin and Body Membranes -- Incredible Journey: A Visualization Exercise for the Skin -- At the Clinic -- The Finale: Multiple Choice -- Chapter 5 THE SKELETAL SYSTEM -- Bones-An Overview -- Axial Skeleton -- Skull -- Vertebral Column -- Thoracic Cage -- Appendicular Skeleton -- Bone Fractures -- Joints -- Homeostatic Imbalances of Bones and Joints -- Developmental Aspects of the Skeleton -- Incredible Journey: A Visualization Exercise for the Skeletal System -- At the Clinic -- The Finale: Multiple Choice -- Chapter 6 THE MUSCULAR SYSTEM -- Overview of Muscle Tissues -- Microscopic Anatomy of Skeletal Muscle -- Skeletal Muscle Activity -- Muscle Movements, Types, and Names…”

Tabla de Contenidos:

Tabla de Contenidos: “…DiPiro -- Chapter 73: Acid-Base Disorders -- Chapter 74: Acute Kidney Injury -- Chapter 75: Chronic Kidney Disease -- Chapter 76: Electrolyte Homeostasis -- SECTION 15: RESPIRATORY DISORDERS Edited by Terry L. …”

Tabla de Contenidos: “…PREVIOUS RECOMMENDATIONS FROM PROFESSIONAL ORGANIZATIONS -- USAGE PATTERNS -- SCOPE OF REPORT -- UNDERLYING ASSUMPTIONS -- ORGANIZATION OF THE REPORT -- References -- 12 Assessment of Nutrient Needs -- NUTRIENT HOMEOSTASIS -- ASSESSMENT OF NUTRITIONAL STATUS -- ASSESSMENT OF NUTRIENT NEEDS -- ASSESSMENT OF DIETARY ADEQUACY -- RECOMMENDED DIETARY ALLOWANCES -- FACTORS INFLUENCING NUTRIENT REQUIREMENTS AND THE NEED FOR SUPPLEMENTATION -- NUTRIENT-NUTRIENT INTERACTIONS -- NUTRIENT TOXICITIES -- SUMMARY -- CLINICAL IMPLICATIONS -- References -- 13 Dietary Intake During Pregnancy -- AVAILABLE DIETARY DATA -- LIMITATIONS OF THE DATA -- NUTRIENT INTAKES OF PREGNANT WOMEN -- ASSOCIATIONS OF MATERNAL CHARACTERISTICS WITH NUTRIENT INTAKE DURING PREGNANCY -- Ethnic Background -- Socioeconomic and Demographic Factors -- WIC Participation -- Maternal Age -- SUMMARY -- References -- 14 Iron Nutrition During Pregnancy -- IMPORTANCE OF IRON DURING PREGNANCY -- Definition of Anemia and Iron Deficiency -- Effects of Maternal Anemia on the Newborn -- PREVALENCE OF IRON DEFICIENCY -- SPECIAL GROUPS AT RISK -- Socioeconomic Indicators -- Racial and Ethnic Backgrounds -- Adolescents -- IRON METABOLISM IN RELATION TO PREGNANCY -- Essential and Storage Iron -- Iron Loss -- Regulation of Body Iron -- Absorption of Nonheme and Heme Iron from Food -- Intestinal Regulation -- IRON REQUIREMENTS FOR PREGNANCY -- CHARACTERISTICS OF IRON DEFICIENCY DURING PREGNANCY -- Laboratory Characteristics of Impaired Hemoglobin Production -- Physiologic Changes in Hemoglobin Concentration and Criteria for Anemia During Pregnancy -- ABSORPTION OF IRON SUPPLEMENTS -- Absorption from a Test Dose -- Therapeutic Trials -- How Much Extra Iron Must Be Absorbed from a Supplement in Order To Prevent Iron Deficiency? …”

Tabla de Contenidos: “…4.1 The RtcA RNA Cyclase -- 4.2 The RtcB RNA Ligase -- 4.3 The RtcB RNA Ligase in Prokaryotes -- 4.4 The RtcB RNA Ligase in Metazoans -- 5 The Bacterial Rtc RNA Repair System -- 5.1 Diversity of the rtc Operon in Bacteria -- 5.2 The RtcR Transcriptional Regulator and Its CARF Domain -- 5.3 Expression and Function of the Rtc System in Bacteria -- 6 Conclusions -- References -- Part II: RNA Damage and Repair in Eukaryotes -- Oxidative and Nitrative RNA Modifications in Plants -- 1 Introduction -- 2 Oxidative Modifications of RNA in Plants -- 3 Nitrative Modifications of RNA in Plants -- 4 Conclusions -- References -- The Role of Ribonucleases in RNA Damage, Inactivation and Degradation -- 1 Introduction -- 2 Quality Control Mechanisms to Manage Damaged RNA -- 3 Ribosome Quality Control (RQC) and No-Go-Decay (NGD) -- 4 Xrn1, a 5'-3' Exoribonuclease, and the Exosome, a 3'-5' Exoribonuclease Complex -- 5 Cue2 as a Potential NGD Endonuclease -- 6 The Role of Ribonucleases in Targeting and Inactivating Host and Foreign RNA -- 7 Regulatory RNase 1 (Regnase-1) -- 8 NEDD4-Binding Protein 1 (N4BP1) -- 9 Zinc Finger Antiviral Protein (ZAP) and Co-Factor Nucleases -- 10 ZAP and KHNYN -- 11 ZAP and the Exosome Complex -- 12 The 2',5'-Oligoadenylate Synthetase (OAS)/RNAse L System -- 13 Conclusion -- References -- Cytoplasmic mRNA Recapping: An Unexpected Form of RNA Repair -- 1 The Nature of the Cap and Its Role in mRNA Metabolism -- 2 Decapping and 5' Decay -- 3 Early Evidence for Uncapped and Recapped Transcripts -- 4 The Discovery of Cytoplasmic Capping -- 5 The Proteins of the Cytoplasmic Capping Complex -- 6 Cap Homeostasis as an RNA Repair Mechanism That Modulates Translation, mRNA Decay, and Translational Control -- 7 Is There a Relationship Between Recapped Ends and CAGE Tags? …”

Tabla de Contenidos: “…Summary -- Introduction -- 1.1 Protein aggregation and amyloidoses -- 1.1.1 Mechanisms of amyloid fibril formation -- 1.1.2 Oligomer structural polymorphism: fibrillar and prefibrillar oligomers -- 1.1.3 Oligomer toxicity: common mechanism of pathogenesis -- 1.1.4 Amyloid formation is an inherent property of polypeptide chains: functional amyloid and disease unreleated amyloid -- 1.2 HypF-N: model protein of amyloid aggregation unrelated to disease -- 1.2.1 Function, structure and aggregation of HypF-N -- 1.2.2 HypF-N protofibrils interact with cell membranes originating a cytotoxic cascade -- 1.2.3 A causative link between the structure of HypF-N oligomers and their ability to cause cellular dysfunction -- 1.3 Alzheimer's disease -- 1.3.1 The Alzheimer phenotype -- 1.3.2 The elaborate processing of APP -- 1.3.3 The genetics of Alzheimer's disease -- 1.3.4 Peripheral cells as a tool to identify and test hypotheses on AD pathophysiology -- 1.3.5 Adult neurogenesis and stem cell technology for AD -- 1.4 Cholesterol and gangliosides in the central nervous system (CNS) -- 1.4.1 Brain cholesterol metabolism -- 1.4.2 Ganglioside metabolism -- 1.4.3 Lipid rafts -- 1.4.4 Role of cholesterol in AD -- 1.4.5 Role of gangliosides in AD -- 1.5 Aim of the study -- Materials & Methods -- 2.1 Materials -- 2.1.1 Chemicals -- 2.1.2 Fluorescent probes -- 2.1.3 Peptides and aggregation protocols -- 2.2 Cell cultures -- 2.3 Methods -- 2.3.1 Separation processes -- 2.3.2 Differentiation of human mesenchymal stromal cells -- 2.3.3 Modulation of membrane cholesterol levels -- 2.3.4 Modulation of membrane GM1 levels -- 2.3.5 Cholesterol content measurements -- 2.3.6 GM1 content measurements -- 2.3.7 Cell exposure to peptide aggregates -- 2.3.8 Analysis of aggregate interaction with the cells -- 2.3.9 Analysis of aggregate interaction with GM1 -- 2.3.10 Analysis of aggregate internalisation -- 2.3.11 Analysis of membrane permeability -- 2.3.12 Analysis of cytosolic Ca2+ dyshomeostasis -- 2.3.13 Evaluation of ROS production -- 2.3.14 Analysis of lipid peroxidation -- 2.3.15 Cytotoxicity assay and cell death analysis: apoptotic and necrotic markers -- 2.3.16 Steady-state fluorescence anisotropy -- 2.3.17 Atomic force microscopy (AFM) -- 2.3.18 Measurements of the fluorescence intensities -- 2.3.19 Statistical analysis -- Results -- 3.1 Results I -- 3.1.1 A protective role for lipid raft cholesterol against amyloidinduced membrane damage in human neuroblastoma cells -- 3.1.2 Aß42 oligomer binding to the cell surface and its cytotoxic effect are modulated by membrane cholesterol content -- 3.1.3 Aß42 oligomers colocalize with lipid rafts -- 3.1.4 Isolation and characterization of DRMs -- 3.1.5 Effects of ADDLs on lipid raft structural order -- 3.1.6 AFM imaging of supported DRMs purified from cells exposed to ADDLs -- 3.2 Results II -- 3.2.1 Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease -- 3.2.2 Lipid rafts are primary interaction sites for Aß42 oligomers at the plasma membrane -- 3.2.3 Cholesterol and GM1 mediate Aß42 accumulation at the plasma membrane -- 3.2.4 Cholesterol and GM1 mediate Ca2+ dyshomeostasis and extensive membrane permeabilization induced by Aß42 oligomers -- 3.2.5 GM1 modulates lipid peroxidation and cytotoxicity induced by Aß42 oligomers -- 3.2.6 GM1 mediates Aß42-induced Ca2+ dyshomeostasis, lipid peroxidation and cytotoxicity in rat cortical neurons -- 3.3 Results III -- 3.3.1 Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers -- 3.3.2 Membrane cholesterol content modulates oligomer cytotoxicity -- 3.3.3 Membrane cholesterol modulates oligomer-induced alteration of intracellular Ca2+ homeostasis and ROS levels -- 3.3.4 Cholesterol levels modulate membrane permeability to the oligomers -- 3.3.5 Membrane GM1 affects the cytotoxic and permeabilizing effects of HypF-N oligomers -- 3.3.6 GM1, rather than cholesterol, plays a dominant role in oligomer cytotoxicity and membrane permeability -- 3.4 Results IV -- 3.4.1 Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aß42 aggregate toxicity -- 3.4.2 Neuronal differentiation of hMSCs results in reduced levels of membrane GM1 -- 3.4.3 Neuronal differentiation of hMSCs reduces the interaction of Aß42 oligomers with the cell surface -- 3.4.4 Neuronal differentiation of hMSCs reduces Aß42 oligomerinduced intracellular Ca2+ dyshomeostasis and oxidative stress -- 3.4.5 Neuronal differentiation of hMSCs increases cell resistance to Aß42 aggregates Discussion -- 4.1 A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells -- 4.2 Lipid rafts mediate amyloid-induced calcium dyshomeostasis and membrane permeabilization in Alzheimer's fibroblasts -- 4.3 Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers -- 4.4 Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aß42 aggregate toxicity -- 4.5 Concluding remarks -- Abbreviations -- References…”

Tabla de Contenidos: “…Overview of Violations and Noncompliance -- Key Points -- 7.1 Human error -- Models of Human Error -- The Skills, Rules, Knowledge Framework -- Slips, Lapses, and Mistakes -- Human Information Processing Model -- Model of Situational Awareness -- Human Errors in the Context of a Flawed System -- Prevalence of Human Error -- Performance Shaping Factors -- Human Limits and Susceptibility to Bias -- Potential Solutions for Managing Human Error -- Summary: Human Error -- Key Points -- References -- 7.2 Intentional noncompliance -- Recognizing Intentional Noncompliance -- Tools and Methods for Analyzing Noncompliant Behaviors -- Work Compatibility Model -- ABC Model -- Theory of Planned Behavior -- The Links Between Noncompliance and Safety Culture -- Risk Homeostasis and Safety Noncompliance -- Actions to Reduce Intentional Noncompliances -- Summary: Intentional Noncompliance -- Key Points -- References -- References -- 8 Human factors in incident investigation -- List of Abbreviations -- The Investigation Process -- Key Stages of an Investigation -- Investigation Methods -- Advantages of Mainstream Methods -- Disadvantages of Mainstream Methods -- Choice of Method -- Including Human Factors Within Existing Investigation Methods -- Human Factors Considerations for Investigators -- Key Qualities of Investigators -- Interviewing Skills -- Cognitive Bias in the Investigation Process -- Managing Investigation Capability -- Proactive Application of Human Factors Analysis -- Summary: Human Factors in Incident Investigation -- Key Points -- References -- III. …”