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1321Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologistspor Copeland, Robert AllenTabla de Contenidos: “…Lead Optimization and Structure-Activity Relationships for Reversible Inhibitors.5.1 Concentration-Response Plots and IC50 Determination.5.1.1 The Hill Coefficient.5.1.2 Graphing and Reporting Concentration-Response Data.5.2 Testing for Reversibility.5.3 Determining Reversible Inhibition Modality and Dissociation Constant.5.4 Comparing Relative Affinity.5.4.1 Compound Selectivity.5.5 Associating Cellular Effects with Target Enzyme Inhibition.5.5.1 Cellular Phenotype Should Be Consistent with Genetic Knockout or Knockdown of the Target Enzyme.5.5.2 Cellular Activity Should Require a Certain Affinity for the target Enzyme.5.5.3 Buildup of Substrate and/or Diminution of Product for the Target Enzyme Should Be Observed in Cells.5.5.4 Cellular Phenotype Should Be Reversed by Cell-Permeable Product or Downstream Metabolites of the Target Enzyme Activity.5.5.5 Mutation of the Target Enzyme Should Lead to Resistance or Hypersensitivity to Inhibitors.5.6 Summary.References.6. …”
Publicado 2013
Universidad Loyola - Universidad Loyola Granada (Otras Fuentes: Biblioteca de la Universidad Pontificia de Salamanca)Enlace del recurso
Libro electrónico -
1322Publicado 2012Tabla de Contenidos: “…Chapter 13 - Introduction to Spread Spectrum SystemsChapter 14 - Signal Space; Chapter 15 - Optimum Receivers; Chapter 16 - MIMO Systems for Diversity and Interference Mitigation; Chapter 17 - High-Throughput MIMO Systems; Chapter 18 - Digital Communication System Performance*; Chapter 19 - Fundamental Limitations on Increasing Data Rate in Wireless Systems; Chapter 20 - Interference and Its Impact on System Capacity; Chapter 21 - Cell Design Principles; Chapter 22 - Wireless Data; Chapter 23 - Third-Generation Cellular Communications: An Air Interface Overview…”
Biblioteca Universitat Ramon Llull (Otras Fuentes: Universidad Loyola - Universidad Loyola Granada, Biblioteca de la Universidad Pontificia de Salamanca)Libro electrónico -
1323por NATO Advanced Research Workshop on Problems of High Altitude Medicine and BiologyTabla de Contenidos: “…Introduction: 45 Years Of Mountain Medicine -- High Altitude Pulmonary Hypertension And Chronic Mountain Sickness-Reappraisal Of The Consensus On Chronic And Subacute High Altitude Diseases -- The Cellular Effects Of Hypoxia In The Pulmonary Circulation -- Angiogenesis And Chronic Hypoxic Pulmonary Hypertension -- Tetrahydrobiopterin And Pulmonary Hypertension -- Hypoxia-Induced Proliferation Of Human Pulmonary Arterial Smooth Muscle Cells (Pasmc) Is Involved In The Suppression Of Cyclin-Dependent Kinase Inhibitors, P21, P27 And P53 -- Pulmonary Adaptation To High Altitude In Wild Mammals -- The Lung At High Altitude: Between Physiology And Pathology -- Sildenafil And Hypoxic Pulmonary Hypertension -- The Role Of Antioxidants In Modulation Of Acclimatization Processes -- Gene Polymorphisms And High Altitude Pulmonary Hypertension -- Genetic Factors In The Acute Response To Hypoxia In Animals Models -- Who Gets High Altitude Pulmonary Edema And Why? …”
Publicado 2007
Libro electrónico -
1324Publicado 2001Tabla de Contenidos: “…Gordon Gibson -- Mechanisms of chemically induced injury and cellular protection mechanisms / Donald J. Reed -- Nutritional factors / William E. …”
Libro -
1325Publicado 2016Tabla de Contenidos: “…1.4.5 - Plug in electric vehicle1.5 - Smart grid; References; Chapter 2 - Integration of distributed energy resources in distribution power systems; 2.1 - Introduction; 2.2 - Interconnection issues and countermeasures; 2.2.1 - Volt-VAR control; 2.2.2 - Gossip-like VVC MAS procedure; 2.3 - Role of ICT in the integration of distributed energy resources; 2.3.1 - Models of the communication networks; 2.3.1.1 - Wired communication network model; 2.3.1.2 - Cellular communication network model; 2.3.2 - Model of the power distribution feeder; 2.3.3 - Test results…”
Libro electrónico -
1326Publicado 2014Tabla de Contenidos: “…Front Cover; Emerging Technologies and Management of Crop Stress Tolerance; Copyright Page; Dedication; Contents; Preface; Acknowledgments; About the Editors; List of Contributors; 1 Genomic Approaches and Abiotic Stress Tolerance in Plants; 1.1 Introduction; 1.2 Physiological, cellular, and biochemical mechanisms of abiotic stress in plants; 1.2.1 Organic and inorganic solutes; 1.2.2 Role of abscisic acid under abiotic stress; 1.2.3 Reactive oxygen species; 1.3 Effects of abiotic stresses on physiological, cellular, and biochemical processes in plants…”
Libro electrónico -
1327Publicado 2010Tabla de Contenidos: “…Collins -- Current approaches to phylogenomic reconstruction / Denis Baurain & Hervé Philippe -- The universal tree of life and the Last Universal Cellular Ancestor : revolution and counterrevolutions / Patrick Forterre -- Eukaryotic evolution : the importance of the stem group / Anthony M. …”
Universidad Loyola - Universidad Loyola Granada (Otras Fuentes: Biblioteca de la Universidad Pontificia de Salamanca)Enlace del recurso
Libro electrónico -
1328Publicado 2012“…"Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. …”
Universidad Loyola - Universidad Loyola Granada (Otras Fuentes: Biblioteca de la Universidad Pontificia de Salamanca)Enlace del recurso
Libro electrónico -
1329Publicado 2014“…The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication…”
Libro electrónico -
1330Publicado 2019“…The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. …”
Libro electrónico -
1331Publicado 2019“…The chains that are metabolized by glycan-related enzymes (glycosyltransferases and glycosidases) are recognized by glycan-binding proteins (lectins) which regulate cellular processes such as growth, differentiation, and death. …”
Libro electrónico -
1332Publicado 2021“…Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. …”
Libro electrónico -
1333Publicado 2020“…Studies of mycotoxins’ effects at the cellular level precede those in organs and systems. …”
Libro electrónico -
1334Publicado 2023Tabla de Contenidos: “…Preface to "Feature Papers of Drones-Volume I" vii -- Propeller Position Effects over the Pressure and Friction Coefficients over the Wing of an UAV with Distributed Electric Propulsion: A Proper Orthogonal Decomposition Analysis 1 -- Optimum Sizing of Photovoltaic-Battery Power Supply for Drone-Based Cellular Networks 31 -- Computational Study of the Propeller Position Effects in Wing-Mounted, Distributed Electric Propulsion with Boundary Layer Ingestion in a 25 kg Remotely Piloted Aircraft 49 -- Biomimetic Drones Inspired by Dragonflies Will Require a Systems Based Approach and -- Insights from Biology 67 -- Suitability of the Reforming-Controlled Compression Ignition Concept for UAV Applications 91 -- Modeling and Investigations on Surface Colors of Wings on the Performance of Albatross-Inspired Mars Drones and Thermoelectric Generation Capabilities 109 -- Unmanned Autogyro for Mars Exploration: A Preliminary Study 131 -- Safety Enhancement of UAVs from the Signal Processing's Perspectives: A Bird's Eye View 149 -- Drones in B5G/6G Networks as Flying Base Stations 165 -- On the Performance of a UAV-Aided Wireless Network Based on NB-IoT 183 -- Communication Aware UAV Swarm Surveillance Based on Hierarchical Architecture 203 -- StratoTrans: Unmanned Aerial System (UAS) 4G Communication Framework Applied on the -- Monitoring of Road Traffic and Linear Infrastructure 229 -- SuSy-EnGaD: Surveillance System Enhanced by Games of Drones 243 -- Designing a User-Centered Interaction Interface for Human-Swarm Teaming 263 -- A Single-Copter UWB-Ranging-Based Localization System Extendable to a Swarm of Drones 281 -- Inter-UAV Routing Scheme Testbeds 301 -- Geo-Referenced Mapping through an Anti-Collision Radar Aboard an Unmanned Aerial System 319 -- Long Distance Ground Target Tracking with Aerial Image-to-Position Conversion and -- Improved Track Association 337 -- Acceleration-Aware Path Planning with Waypoints 351 -- A Hybrid Approach for Autonomous Collision-Free UAV Navigation in 3D Partially Unknown Dynamic Environments 369 -- A Multilevel Architecture for Autonomous UAVs 383 -- Efficient Reactive Obstacle Avoidance Using Spirals for Escape 399 -- Simulation and Characterization of Wind Impacts on sUAS Flight Performance for Crash Scene Reconstruction 425.…”
Libro electrónico -
1335Publicado 2023Tabla de Contenidos: “…Design and Application of Cellular Concrete on a Mexican Residential Building and Its Influence on Energy Savings in Hot Climates: Projections to 2050 Reprinted from: Appl. …”
Libro electrónico -
1336Publicado 1997“…Because many of the new developments involve commonly available equipment such as cellular telephones and satellite dishes, technicians as well as engineers must learn the basics of the technology.Microwave & Wireless Communications Technology offers a practical, device-based approach to the study of microwave and wireless communications. …”
Libro electrónico -
1337por Institute of Medicine (U.S.).“…This perception stemmed from the focus of most investigators on organisms that could be grown in the laboratory as cellular monocultures, often dispersed in liquid, and under ambient conditions of temperature, lighting, and humidity. …”
Publicado 2012
Libro electrónico -
1338Publicado 2016Tabla de Contenidos: “…Blood-brain barrier pathophysiology following traumatic brain injury / Lulit Price, Christy Wilson, and Gerald Grant -- chapter 5. Cellular and molecular mechanisms of secondary neuronal injury following traumatic brain injury / Kamesh Krishnamurthy and Daniel T. …”
Libro electrónico -
1339Publicado 2012Tabla de Contenidos: “…Roelen, Robert Passier and Susan Gibbs -- 4. Cellular signalingVanessa LaPointe and Kristopher A. …”
Libro electrónico -
1340por Lescuyer, Pierre, 1967-Tabla de Contenidos: “…. -- 6.2 Push-to-talk Over Cellular. -- 6.3 Presence. -- 6.4 Broadcast and Multicast. -- 6.5 Voice and Multimedia Telephony. -- Glossary. -- Index…”
Publicado 2008
Libro electrónico