Tabla de Contenidos: “…Summary -- Introduction -- 1.1 Protein aggregation and amyloidoses -- 1.1.1 Mechanisms of amyloid fibril formation -- 1.1.2 Oligomer structural polymorphism: fibrillar and prefibrillar oligomers -- 1.1.3 Oligomer toxicity: common mechanism of pathogenesis -- 1.1.4 Amyloid formation is an inherent property of polypeptide chains: functional amyloid and disease unreleated amyloid -- 1.2 HypF-N: model protein of amyloid aggregation unrelated to disease -- 1.2.1 Function, structure and aggregation of HypF-N -- 1.2.2 HypF-N protofibrils interact with cell membranes originating a cytotoxic cascade -- 1.2.3 A causative link between the structure of HypF-N oligomers and their ability to cause cellular dysfunction -- 1.3 Alzheimer's disease -- 1.3.1 The Alzheimer phenotype -- 1.3.2 The elaborate processing of APP -- 1.3.3 The genetics of Alzheimer's disease -- 1.3.4 Peripheral cells as a tool to identify and test hypotheses on AD pathophysiology -- 1.3.5 Adult neurogenesis and stem cell technology for AD -- 1.4 Cholesterol and gangliosides in the central nervous system (CNS) -- 1.4.1 Brain cholesterol metabolism -- 1.4.2 Ganglioside metabolism -- 1.4.3 Lipid rafts -- 1.4.4 Role of cholesterol in AD -- 1.4.5 Role of gangliosides in AD -- 1.5 Aim of the study -- Materials & Methods -- 2.1 Materials -- 2.1.1 Chemicals -- 2.1.2 Fluorescent probes -- 2.1.3 Peptides and aggregation protocols -- 2.2 Cell cultures -- 2.3 Methods -- 2.3.1 Separation processes -- 2.3.2 Differentiation of human mesenchymal stromal cells -- 2.3.3 Modulation of membrane cholesterol levels -- 2.3.4 Modulation of membrane GM1 levels -- 2.3.5 Cholesterol content measurements -- 2.3.6 GM1 content measurements -- 2.3.7 Cell exposure to peptide aggregates -- 2.3.8 Analysis of aggregate interaction with the cells -- 2.3.9 Analysis of aggregate interaction with GM1 -- 2.3.10 Analysis of aggregate internalisation -- 2.3.11 Analysis of membrane permeability -- 2.3.12 Analysis of cytosolic Ca2+ dyshomeostasis -- 2.3.13 Evaluation of ROS production -- 2.3.14 Analysis of lipid peroxidation -- 2.3.15 Cytotoxicity assay and cell death analysis: apoptotic and necrotic markers -- 2.3.16 Steady-state fluorescence anisotropy -- 2.3.17 Atomic force microscopy (AFM) -- 2.3.18 Measurements of the fluorescence intensities -- 2.3.19 Statistical analysis -- Results -- 3.1 Results I -- 3.1.1 A protective role for lipid raft cholesterol against amyloidinduced membrane damage in human neuroblastoma cells -- 3.1.2 Aß42 oligomer binding to the cell surface and its cytotoxic effect are modulated by membrane cholesterol content -- 3.1.3 Aß42 oligomers colocalize with lipid rafts -- 3.1.4 Isolation and characterization of DRMs -- 3.1.5 Effects of ADDLs on lipid raft structural order -- 3.1.6 AFM imaging of supported DRMs purified from cells exposed to ADDLs -- 3.2 Results II -- 3.2.1 Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease -- 3.2.2 Lipid rafts are primary interaction sites for Aß42 oligomers at the plasma membrane -- 3.2.3 Cholesterol and GM1 mediate Aß42 accumulation at the plasma membrane -- 3.2.4 Cholesterol and GM1 mediate Ca2+ dyshomeostasis and extensive membrane permeabilization induced by Aß42 oligomers -- 3.2.5 GM1 modulates lipid peroxidation and cytotoxicity induced by Aß42 oligomers -- 3.2.6 GM1 mediates Aß42-induced Ca2+ dyshomeostasis, lipid peroxidation and cytotoxicity in rat cortical neurons -- 3.3 Results III -- 3.3.1 Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers -- 3.3.2 Membrane cholesterol content modulates oligomer cytotoxicity -- 3.3.3 Membrane cholesterol modulates oligomer-induced alteration of intracellular Ca2+ homeostasis and ROS levels -- 3.3.4 Cholesterol levels modulate membrane permeability to the oligomers -- 3.3.5 Membrane GM1 affects the cytotoxic and permeabilizing effects of HypF-N oligomers -- 3.3.6 GM1, rather than cholesterol, plays a dominant role in oligomer cytotoxicity and membrane permeability -- 3.4 Results IV -- 3.4.1 Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aß42 aggregate toxicity -- 3.4.2 Neuronal differentiation of hMSCs results in reduced levels of membrane GM1 -- 3.4.3 Neuronal differentiation of hMSCs reduces the interaction of Aß42 oligomers with the cell surface -- 3.4.4 Neuronal differentiation of hMSCs reduces Aß42 oligomerinduced intracellular Ca2+ dyshomeostasis and oxidative stress -- 3.4.5 Neuronal differentiation of hMSCs increases cell resistance to Aß42 aggregates Discussion -- 4.1 A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells -- 4.2 Lipid rafts mediate amyloid-induced calcium dyshomeostasis and membrane permeabilization in Alzheimer's fibroblasts -- 4.3 Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers -- 4.4 Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aß42 aggregate toxicity -- 4.5 Concluding remarks -- Abbreviations -- References…”

Tabla de Contenidos:

Tabla de Contenidos: “…3.7 SPRAY-APPLIED RIGID-CELLULAR POLYURETHANE (PUR) AND POLYISOCYANURATE (PIR) THERMAL INSULATION3.8 PREFORMED RIGID-CELLULAR POLYURETHANE (PUR) AND POLYISOCYANURATE (PIR) THERMAL INSULATION; 3.9 MISCELLANEOUS MATERIALS TO BE USED WITH THERMAL INSULATION; Chapter Four - Cryogenic Insulation Systems for LNG Industries; 4.1 POLYURETHANE; 4.2 MULTILAYER INSULATION: SUPER INSULATION; 4.3 FOAM INSULATION; 4.4 PERLITE; 4.5 CETRAFOAM; 4.6 OTHER INSULATION SYSTEMS; 4.7 CRYOGENIC INSULATION SYSTEM PERFORMANCE; 4.8 ARMAFLEX CRYOGENIC SYSTEMS; 4.9 AEROGELS; 4.10 CRYOGENIC VACUUM PIPE…”

Tabla de Contenidos: “…Preface -- 1 Introduction / -- 1.1 Generations / -- 1.2 Standards / -- 1.3 Cellular Standards Organizations 3GPP and 3GPP2 / -- 1.4 IEEE Standards / -- 1.5 Advanced Mobile Wireless Systems Based on FDMA / -- 1.6 Figures of Merit / -- 1.7 Frequency Division Technology in Broadband Wireless -- Systems / -- References -- 2 Channel Characteristics and Frequency Multiplexing -- 2.1 Introduction -- 2.2 Radio Channel Characteristics -- 2.3 Orthogonal Frequency Division Multiplexing -- 2.4 Single Carrier Modulation with Frequency Domain Equalization -- 2.5 Summary -- References -- 3 Single Carrier FDMA / -- 3.1 Introduction / -- 3.2 SC-FDMA Signal Processing / -- 3.3 Subcarrier Mapping / -- 3.4 Time Domain Representation of SC-FDMA Signals / -- 3.5 SC-FDMA and Orthogonal Frequency Division Multiple Access / -- 3.6SC-FDMA and CDMA with Frequency Domain Equalization / -- 3.7Single Carrier Code-Frequency Division Multiple Access (SC-CFDMA) / -- 3.8 Summary / -- References -- 4 SC-FDMA in 3GPP Long Term Evolution / -- 4.1 Introduction / -- 4.2 Protocol Layers and Channels / -- 4.3 Uplink Time and Frequency Structure / -- 4.4 Basic Uplink Physical Channel Processing / -- 4.5 Reference (Pilot) Signal Structure / -- 4.6 Summary / -- References / -- Appendix - List of 3GPP LTE Standards -- 5 Channel Dependent Scheduling / -- 5.1 Introduction / -- 5.2 SC-FDMA Performance Measures / -- 5.3 Scheduling Algorithms / -- 5.4 Channel Models Used in Scheduling Studies / -- 5.5 Channel-Dependent Scheduling Simulation Studies / -- 5.6 Summary / -- References -- 6 MIMO SC-FDMA / -- 6.1 Introduction / -- 6.2 Spatial Diversity and Spatial Multiplexing in MIMO Systems / -- 6.3 MIMO Channel / -- 6.4 SC-FDMA Transmit Eigen-Beamforming with Unitary Precoding / -- 6.5 SC-FDMA Spatial Diversity / -- 6.6 Summary / -- References -- 7 Peak Power Characteristics of an SC-FDMA Signal / -- 7.1 Introduction / -- 7.2 Peak Power Characteristics of a Single Carrier Signal / -- 7.3 PAPR of Single Antenna Transmission Signals /.…”

Tabla de Contenidos: “…Using star networks -- Working with The Things Network -- Understanding gateways on TTN -- Understanding applications on TTN -- Purchasing and setting up radios and gateways -- Buying LoRaWAN-certified gateways -- Buying LoRaWAN-certified microcontrollers -- Getting the microcontroller's EUI -- Summary -- Further reading -- Chapter 8: Working with Ethernet -- Technical requirements -- Introduction to Ethernet -- Arduino devices that support Ethernet -- Installing Arduino Portenta board drivers -- Communicating over Ethernet -- Creating an AccuWeather app -- Getting your API key -- Getting your location key -- Getting the weather conditions -- Project 1 - Setting the onboard LED's intensity based on the temperature -- Summary -- Chapter 9: Leveraging Cellular Communication Technology -- Technical requirements -- Learning about cellular connectivity -- Choosing cellular radios -- Deployments in North America -- Deployments in EMEA -- Blues Wireless -- Arduino cellular options -- Making phone calls -- Project 1 - Making a call with the MKR GSM -- Working with SMS -- Project 2 - Receiving an SMS -- Project 3 - Sending temperature and humidity data via SMS -- Working with GPRS -- Project 4 - sending temperature and humidity data over GPRS -- Summary -- Further reading -- Chapter 10: Communicating via HC-12 -- Technical requirements -- Learning about HC-12 -- Acquiring HC-12 modules -- Setting up the hardware -- Configuring the HC-12 module -- Sending and receiving data -- Exercise 10.1 - displaying whatever the HC-12 module receives -- Sending temperature and humidity over HC-12 -- Summary -- Further reading -- Chapter 11: Managing Communication with RS-485 -- Technical requirements -- Introducing RS-485 -- Benefits of RS-485 -- Cons of RS-485 -- RS-485 hardware -- Introducing Modbus -- Modbus pros -- Modbus cons -- Modbus hardware…”

Tabla de Contenidos: “…Fahmy -- Other non-stem cell therapies for cellular tracking, inflammatory cell tracking / Yijen L. …”
Enlace del recurso

Tabla de Contenidos: “…""Tempo And Mode In Evolution""; ""Copyright""; ""PREFACE""; ""REFERENCES""; ""Contents""; ""PART I EARLY LIFE""; ""1 Tempo, Mode, the Progenote, and the Universal Root""; ""STAGES IN THE EVOLUTION OF THE CELLULAR INFORMATION-PROCESSING SYSTEM""; ""THE BASIC KINDS OF LIVING THINGS""; ""THE WOESIAN REVOLUTION""; ""ROOTING THE UNIVERSAL TREE""; ""IMPLICATIONS OF THE ROOTING FOR AN UNDERSTANDING OF TEMPO AND MODE IN EARLY CELLULAR EVOLUTION""; ""But Is the Rooting Right?""…”

Tabla de Contenidos: “…Chapter 1 - Introduction to mmWave massive MIMO -- Chapter 2 - SISO to mmWave massive MIMO -- Chapter 3 - Hybrid antenna array for mmWave massive MIMO -- Chapter 4 - Encoding and detection in mmWave massive MIMO -- Chapter 5 - Precoding for mmWave massive MIMO -- Chapter 6 - Channel estimation for mmWave massive MIMO systems -- Chapter 7 - Channel feedback for mmWave massive MIMO -- Chapter 8 - mmWave massive MIMO channel modeling -- Chapter 9 - mmWave communication enabling techniques for 5G wireless systems: A link level perspective -- Chapter 10 - MAC layer design for mmWave massive MIMO -- Chapter 11 - Enhanced multiple-access for mmWave massive MIMO -- Chapter 12 - Fronthaul design for mmWave massive MIMO -- Chapter 13 - mmWave cellular networks: Stochastic geometry modeling, analysis, and experimental validation…”

Tabla de Contenidos: “…-- Degradation Assessment of Natural Stone Claddings over Their Service Life: Comparison between Tehran (Iran) and Lisbon (Portugal) -- Most Frequent Problems of Building Structures of Urban Apartment Buildings from 2nd Half of 19th Century and the Start of 20th Century -- Critical Analysis about Emerging Technologies for Building's Fac ̧ade Inspection -- Microclimate of Air Cavities in Ventilated Roof and Fac ̧ade Systems in Nordic Climates -- Structural Performance Assessment of Innovative Hollow Cellular Panels for Modular Flooring System -- Insurance Policies for Condition-Based Maintenance Plans of ETICS -- Integrated Building Maintenance and Safety Framework: Educational and Public Facilities Case Study…”

Tabla de Contenidos: “…The study of life -- The chemical foundation of life -- Biological macromolecules -- Cell structure -- Structure and function of plasma membranes -- Metabolism -- Cellular respiration -- Photosynthesis -- Cell communication -- Cell reproduction -- Meiosis and sexual reproduction -- Mendel's experiments and heredity -- Modern understandings of inheritance -- DNA structure and function -- Genes and proteins -- Gene expression -- Biotechnology and genomics -- Evolution and the origin of species -- The evolution of populations -- Phylogenies and the history of life -- Viruses -- Prokaryotes : bacteria and archaea -- Protists -- Fungi -- Seedless plants -- Seed plants -- Introduction to animal diversity -- Invertebrates -- Vertebrates -- Plant form and physiology -- Soil and plant nutrition -- Plant reproduction -- The animal body : basic form and function -- Animal nutrition and the digestive system -- The nervous system -- Sensory systems -- The endocrine system -- The musculoskeletal system -- The respiratory system -- The circulatory system -- Osmotic regulation and excretion -- The immune system -- Animal reproduction and development -- Ecology and the biosphere -- Population and community ecology -- Ecosystems -- Conservation biology and biodiversity -- The periodic table of elements -- Geological time -- Measurements and the metric system…”

Tabla de Contenidos: “…The study of life -- The chemical foundation of life -- Biological macromolecules -- Cell structure -- Structure and function of plasma membranes -- Metabolism -- Cellular respiration -- Photosynthesis -- Cell communication -- Cell reproduction -- Meiosis and sexual reproduction -- Mendel's experiments and heredity -- Modern understandings of inheritance -- DNA structure and function -- Genes and proteins -- Gene expression -- Biotechnology and genomics -- Evolution and the origin of species -- The evolution of populations -- Phylogenies and the history of life -- Viruses -- Prokaryotes : bacteria and archaea -- Protists -- Fungi -- Seedless plants -- Seed plants -- Introduction to animal diversity -- Invertebrates -- Vertebrates -- Plant form and physiology -- Soil and plant nutrition -- Plant reproduction -- The animal body : basic form and function -- Animal nutrition and the digestive system -- The nervous system -- Sensory systems -- The endocrine system -- The musculoskeletal system -- The respiratory system -- The circulatory system -- Osmotic regulation and excretion -- The immune system -- Animal reproduction and development -- Ecology and the biosphere -- Population and community ecology -- Ecosystems -- Conservation biology and biodiversity -- The periodic table of elements -- Geological time -- Measurements and the metric system…”

Tabla de Contenidos: “…Chapter 14: Composite Food ProductsChapter 15: Gel-Like Close Packed Materials; Chapter 16: Cellular Materials; Chapter 17: Hard Solids; Chapter 18: Texture Perception; Appendix A: List of Frequently Used Symbols; Appendix B: SI Units Used; Appendix C: Derivation of Equations 7.32 and 7.33 Using Complex Notations; Back Cover…”

Tabla de Contenidos: “…Artificial intelligence empowered 3D bioprinting / Neha Bhardwaj, Meenakshi Sood, SS Gill -- AI and IoT in smart healthcare / Sharu Bansal and Dilip Kumar -- Spintronic technology for artificial intelligent applications / Parul Sharma, Sandeep Singh Gill and Balwinder Raj -- AI-based ECG signal monitoring system for arrhythmia detection using IOMT / Pushparaj, Amod Kumar and Garima Saini -- Fast image desmogging for road safety using optimized dark channel prior / Akshay Juneja, Vijay Kumar and Sunil Kumar Singla -- Face masks detection using artificial intelligence / Preetiyanka, Balwant Raj, Meenakshi Devi and Balwinder Raj -- Emerging non volatile memories for AI applications / Mandeep Singh, Tarun Chaudhary and Balwinder Raj -- Intelligent irrigation system / Parveen Kumar, Balwant Raj, Sanjeev Kumar Sharma and Balwinder Raj -- Reversible logic gates using quantum-dot cellular automata nanotechnology / Vijay Kumar Sharma…”

Tabla de Contenidos: “…""Front Matter""; ""Preface""; ""Contents""; ""Public Summary""; ""Executive Summary""; ""1 Introduction""; ""2 Baseline Information on Indoor Radon and Radon in Water in the United States""; ""3 Transfer of Radon from Water to Indoor Air""; ""4 Dosimetry of Ingested Radon and its Associated Risk""; ""5 Dosimetry of Inhaled Radon and its Associated Risk""; ""6 Molecular and Cellular Mechanisms of Radon-Induced Carcinogenesis""; ""7 Defining Key Variabilities and Uncertainties""; ""8 Mitigation""; ""9 Multimedia Approach to Risk Reduction""; ""10 Research Recommendations""; ""References""…”

Tabla de Contenidos: “…Kelch -- Mosses as model organisms for developmental, cellular and molecular biology / Andrew C. Cuming -- Physiological ecology / Michael C.F. …”

Tabla de Contenidos: “…-- Alteration of hematopoietic stem cell fates by chromatin-modifying agents -- Increasing impact of micro RNAs in stem cell biology and medicine -- Novel strategies for the mobilization of hematopoietic stem cell -- Pluripotent stem cells from umbilical cord blood -- Good manufacturing practices: clinical-scale production of mesenchymal stem cells -- The clonal activity of marked hematopoietic stem cell -- A large animal non-injury model for study of human stem cell plasticity -- Developmental potential of somatic stem cells following injection into murine blastocysts -- Testing the limits: the potential of MAPC in animal models -- Mesenchymal stem cells as vehicles for genetic targeting of tumors -- Endothelial progenitor cells for cardiac regeneration -- Stem cells and bypass grafting for myocardial and vascular regeneration -- Adoptive immunotherapy: guidelines and clinical practice -- Immune escape and suppression by human mesenchymal stem cells -- Stem cell transplantation: the basis for successful cellular immunotherapy…”

Tabla de Contenidos: “…Preface to the Fourth Edition -- Introduction to simulation: the ice cream store -- Introduction to SIMIO : the ice cream store -- Modeling distance and examining inputs/outputs -- More detailed modeling: airport revisited -- Data-based modeling; manufacturing cell -- Assembly and packaging: memory chip boards -- Using SIMIO processes -- Working with flow and capacity: the DMV -- The workstation concept: a kitting process -- Inventories, supply chains, and optimization -- Simulation output analysis -- Materials handling -- Management of resources: veterinary clinic -- A mobile resource: the worker -- Adding detail to service: a bank example -- Modeling of call centers -- Sub-modeling; cellular manufactoring -- The anatomy of objects: server -- Building new objects via sub-classing: a delay object -- Creating new objects -- Continuous variables, reneging, interrupt, debugging: a gas station -- More subclassing:advanced modeling of supply chain system -- More subclassing:process planning/project management -- Input modeling…”

“…However, advances in in vivo microscopy over the last 10-15 years have overcome many of these difficulties, and studies using these forms of microscopy have revealed a wealth of new information regarding the cellular and molecular mechanisms of CNS inflammation. …”

“…Mitogen-activated protein kinase (MAPK) pathways are evolutionarily conserved in all eukaryotes and allow cells to respond to changes in the physical and chemical properties of the environment and to produce an appropriate response by altering many cellular functions. MAPKs are among the most intensively studied signal transduction systems. …”

“…Viruses disrupt normal host cell processes in order to facilitate their own replication/assembly by re-directing cellular machinery for viral transcription, translation, assembly, release and by inhibiting antiviral responses. …”