“…ERs have long been evaluated for their roles in controlling the expression of genes involved in vital cellular processes such as proliferation, apoptosis, and differentiation. …”

“…Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. …”

“…This title also provides recent advancements in studies of cellular processes that are coordinated with DNA replication and how defects in the DNA replication program result in genetic disorders, including cancer. …”

“…In this Special Issue, we are especially interested in manuscripts that advance the understanding of the interaction of NMs with cells, such as cellular responses to NMs, intracellular behaviors of NMs, therapeutic and imaging potentials of NMs, as well as the functionalization of NMs through coating, patterning and hybridization with other biomolecules for multifaceted biomedical applications…”

“…Neurochemistry is a vitally important academic discipline that contributes to our understanding of molecular, cellular, and medical neurobiology. As a field, neurochemistry focuses on the role of the chemical entities that build the nervous system, the function of neurons and glial cells in health and disease, aspects of cell metabolism and neurotransmission, and degenerative processes and aging of the nervous system. …”

“…Topics include: Molecular methods to personalize endometrial cancer screening and detection; Identification and new aspects of cellular signaling molecules and pathways for target discovery, drug design, and personalized and gender medicine; DDI discovery in endometrial cancer management; Drug repurposing for endometrial cancer prevention/treatment; Molecular modeling studies…”

“…Topics include: Molecular methods to personalize cancer screening and detection; Molecular target therapies to prevent cancer development and metastases; Identification and new aspects of cellular signaling molecules and pathways for target discovery, drug design and personalized and gender medicine; Drug repurposing for cancer prevention; Molecular modeling studies…”

“…DON is part of a family of mycotoxins called trichothecenes that are small sesquiterpenoids with an epoxide group at positions 12-13 allowing their binding to ribosomes causing the so-called ribosome stress response, characterized by the activation of various protein kinases that lead to alterations in gene expression and cellular toxicity in animals, humans and plants. Here, we compiled very recent findings regarding DON and its derivatives: i. their prevalence in human food; ii. the estimation of the exposure of humans to them using biological markers; iii. their roles during plant-fungi interaction; iv. the alteration caused by them in animals and humans, particularly at low doses that are close to those observed in farm animals and human consumers; v. possible strategies to decrease their presence in food and feeds. …”

“…This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. …”

“…The book has gathered interdisciplinary works, joining fields such as trace elements, biochemistry, physiology and analytical chemistry with the aim of finding new approaches to diseases, for example by using individual treatment at the cellular level…”

“…This book brings to the fore probably the most recent experimental research/review on heavy metal contamination, remediating techniques, cellular tissue damage, and toxicological and antioxidant effects of heavy metals. …”

“…How are resonance textures within cellular entities extended in the body and the mind by means of mirroring processes? …”

“…Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. …”

“…Notably, the talks covered different topics on new therapeutic strategies (targeted therapy and immuno-oncology), molecular and cellular biology, biomarkers, and the epidemiology of lung cancer. …”

Tabla de Contenidos: “…; A Cell Is a Little Sack of Life; Let's Look Inside a Cell; The Nucleus: A Little Brain; Single-Celled and Multicellular Organisms; Prokaryotic Organisms and Eukaryotic Organisms; Chapter 2: Proteins and DNA: Deciphering thegenetic code; Proteins Drive Cellular Activity; Proteins Are Made of Amino Acids; Genes: The Blueprint for Building Proteins; DNA and Nucleotides; The Genome: A Library of Genes; Chapter 3: DNA Replication and Cell Division; Cells Multiply Through Division; DNA Is Replicated Before Cell Division…”

“…Digital holographic imaging has recently emerged as a powerful new technique well suited to explore cell structure and dynamics with a nanometric axial sensitivity and the ability to identify new cellular biomarkers. By combining digital holography with AI technology, including recent deep learning approaches, this system can achieve a record-high accuracy in non-invasive, label-free cellular phenotypic screening. …”

Tabla de Contenidos: “…Introduction and History of the Chemistry of Nucleic Acids Therapeutics -- Antisense RNA Therapeutics: A Brief Overview -- Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion -- Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation -- How to Design U1 snRNA Molecules for Splicing Rescue -- Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles -- Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay -- Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen -- Development and Use of Cellular Systems to Assess and Correct Splicing Defects -- Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells -- In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin -- In Vitro Delivery of PMOs in Myoblasts by Electroporation -- Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts -- Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy -- Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro -- Eye on a Dish Models to Evaluate Splicing Modulation -- Establishment of In Vitro Brain Models for AON Delivery -- Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides -- Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies -- Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment -- In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin -- Delivery of Antisense Oligonucleotides to the Mouse Retina -- Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections -- Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System -- Preclinical Safety Assessment of Therapeutic Oligonucleotides -- Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice -- Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution -- Patent Considerations When Embarking on New Antisense Drug Programs…”

“…Connect via WiFi or the blazing-fast 4G LTE cellular network—and create a free Wi-Fi hotspot with Verizon’s iPad. …”

Tabla de Contenidos: “…The Search for Life's Origins -- Copyright -- Foreword -- Contents -- Executive Summary -- OVERVIEW -- THE COSMIC HISTORY OF THE BIOGENIC ELEMENTS AND COMPOUNDS -- EARLY PLANETARY ENVIRONMENTS: IMPLICATIONS FOR CHEMICAL EVOLUTION AND THE ORIGIN OF LIFE -- THE ORIGIN OF LIFE -- THE EVOLUTION OF CELLULAR AND MULTICELLULAR LIFE -- SEARCH FOR LIFE OUTSIDE THE SOLAR SYSTEM -- MAJOR RESEARCH RECOMMENDATIONS -- Recommendations Requiring Flight Opportunities -- Mars -- Comets and Asteroids -- Titan and the Giant Outer Planets -- The Interstellar Medium and Cosmic Dust Particles -- Recommendations Requiring Ground-Based Studies -- Chemical Evolution and the Origin of Life -- Mars-Related Studies -- Studies Related to Comets and Asteroids -- Studies Related to Titan and the Giant Outer Planets -- Studies Related to the Interstellar Medium and Dust -- Studies Related to the Search for Life Outside the Solar System -- SPACE SCIENCE PROGRAM AND POLICY ISSUES -- 1 Overview -- 2 The Cosmic History of the Biogenic Elements and Compounds -- INTRODUCTION -- SYSTEMATIC STUDIES OF INTERSTELLAR CLOUDS -- COMPLEX MOLECULES -- STAR-FORMING REGIONS AND THE SUBMILLIMETER SPECTRAL RANGE -- GRAIN INTERRELATIONSHIPS -- INFRARED SPECTROSCOPY AND ASTRONOMY -- GRAIN INTERACTIONS -- Future Investigations -- ASTEROIDS -- Future Investigations -- METEORITES -- Future Investigations -- COMETS AND INTERPLANETARY DUST PARTICLES -- Comets -- Interplanetary Dust Particles -- Future Investigations -- 3 Early Planetary Environments: Implications for Chemical Evolution and the Origin of Life -- INTRODUCTION -- THE OUTER PLANETS -- THE TERRESTRIAL PLANETS -- Earth -- Accretion by Impacts -- Tectonics and the Development of Earth's Early Atmosphere and Hydrosphere -- Impacts and Their Influence on Environmental Conditions for the Origin Maintenance of Life -- Mars -- Aqueous Environments…”

Tabla de Contenidos: “…Special Requirements -- 6 Human Biology and Space Medicine -- INTRODUCTION -- EXPERIMENTAL USE OF ANIMALS -- Approach to Scientific Questions -- NEUROSENSORY PHYSIOLOGY -- Introduction -- Background -- Flight Experience -- Space Motion Sickness -- Vestibulo-Spinal Reflexes -- Proposed Research -- Overview -- Visual System -- Tactile and Proprioceptive Systems -- BONE AND MINERAL METABOLISM -- Introduction -- Background -- Flight Experience -- Cellular Mechanisms -- Possibility of Urinary Tract Stone Formation -- Proposed Research -- Characterization -- Cellular Mechanisms -- Nutrition -- Summary -- MUSCLE METABOLISM -- Introduction -- Background -- Flight Experience -- Ground-Based Studies -- Proposed Research -- CARDIOVASCULAR, PULMONARY, AND RENAL SYSTEMS -- Introduction -- Background -- Proposed Research -- Cardiovascular Conditioning -- Pulmonary Function -- Renal Function -- Conclusions and Recommendation -- INTEGRATED FUNCTIONS -- Introduction -- Nutrition -- Background -- Proposed Research -- Immune System -- Background -- Proposed Research -- Other Systems -- RADIATION EFFECTS -- Introduction -- Background -- Space Radiation Environment -- Spacecraft Radiation Environment -- Biological Effects -- Proposed Research -- BEHAVIOR AND PERFORMANCE -- Introduction -- Background -- Proposed Research -- Overview -- Environmental Factors -- Individual Factors -- Group Factors -- Integrative Factors -- Technology and Scientific Resource Requirements -- HEALTH MAINTENANCE -- Introduction -- Types of Care -- Unique Environmental Stresses -- Microorganisms -- Aerosols and Particulates -- Toxic Volatiles -- Water, Air, and Temperature -- Proposed Research -- 7 International Cooperation in Space Life Sciences -- 1. …”