Tabla de Contenidos: “…Review of the Fialuridine (FIAU) Clinical Trials -- Copyright -- Preface -- Contents -- Executive Summary -- INTRODUCTION -- CLINICAL TRIALS -- HEPATITIS B AND OTHER VIRAL DISEASES -- EARLY CLINICAL TRIALS OF FIAC AT MEMORIAL SLOAN-KETTERING CANCER CENTER -- OCLASSEN CLINICAL TRIAL R89-001-01 -- OCLASSEN CLINICAL TRIAL R90-001-01 -- OCLASSEN CLINICAL TRIAL R-91-010 -- ELI LILLY CLINICAL TRIAL H3X-MC-PPPA -- ELI LILLY TRIAL H3X-LC-PPPG -- ELI LILLY TRIAL H3X-MC-PPPC (NIH PROTOCOL #93-DK-0031) -- PATIENT INTERVIEWS -- OVERALL ASSESSMENT OF THE TRIALS -- REVIEW OF THE FDA TASK FORCE REPORT -- REVIEW OF THE NIH REPORT -- FDA-PROPOSED CHANGES TO THE CODE OF FEDERAL REGULATIONS -- ANCILLARY ISSUES -- CONCLUSIONS -- RECOMMENDATIONS -- Generic Issues -- Trial Design -- Adverse Event Reporting -- Compliance Audits -- Further Research Into FIAU Toxicity -- 1 Introduction -- GENESIS OF THIS STUDY -- CHARGE TO THE COMMITTEE -- METHODS AND PROCEDURE -- PLAN OF THE REPORT -- 2 Clinical Trials -- IMPORTANCE OF CLINICAL TRIALS -- THE RISK-BENEFIT NATURE OF TRIALS -- THE DRUG DEVELOPMENT PROCESS -- SAFETY REPORTS -- ETHICAL CONSIDERATIONS -- Procedural Requirements -- Substantive Norms -- A Favorable Balance of Harms and Benefits -- Equitable Selection of Subjects -- Compensation for Research-Related Injury -- Informed Consent -- SUMMARY -- 3 Hepatitis B and Other Viral Diseases -- NATURE OF CHRONIC VIRAL DISEASES -- NATURAL HISTORY OF CHRONIC HBV INFECTION -- NEED FOR ORALLY ACTIVE AGENTS -- THE FLARE PHENOMENON -- TOXIC EFFECTS OF OTHER NUCLEOSIDE ANALOGS -- SUMMARY -- 4 Clinical Trials of FIAC at Memorial Sloan-Kettering Cancer Center -- PHASE I EVALUATION OF FIAC IN IMMUNOSUPPRESSED PATIENTS WITH HERPESVIRUS INFECTION -- Comment -- PHASE I STUDY OF AIDS PATIENTS WITH PRESUMPTIVE OR PROVEN HERPESGROUP VIRUS INFECTION -- Comment…”

Tabla de Contenidos: “…Iterative Sigma Filtering -- Constraint-based Methods -- Parametric Estimation -- 4.3.3 High-speed K-space Coverage Techniques -- 4.3.4 Research Opportunities in Dynamic MR Image Reconstruction -- 4.3.5 Suggested Reading Related to Dynamic MR Image Reconstruction -- 4.4 APPLICATIONS OF DYNAMIC MRI -- 4.4.1 Blood Flow -- Fourier Velocity Encoding -- RF Pulses -- Measurement of Wave Speed and Distensibility -- Postprocessing -- Conclusions Related to MR Imaging of Blood Flow -- 4.4.2 Diffusion Imaging -- Measurement of Diffusion Coefficients in vivo -- Mapping of Diffusion Tensor -- 4.4.3 Other Tissue Parameters -- Relaxation Times -- Oxygen -- Strain -- 4.4.4 Functional Brain MRI -- Contrast Mechanism -- Imaging Techniques -- Hardware Requirements -- Field Strength Considerations As discussed above, local field gradients -- Processing of Functional Images -- Safety Considerations -- Biophysical Modeling -- 4.4.5 Multinuclear MRI -- MR Spectroscopy and Spectroscopic Imaging -- Injected Paramagnetic Contrast Agents and Hyperpolarized Noble Gases -- 4.4.6 Microscopic Imaging -- Resolution -- Signal-to-Noise Ratios -- Gradients -- Diffusion -- Motion -- Future Applications of in vivo MRI Microscopy -- 4.4.7 Research Opportunities Related to Applying Dynamic MRI -- Blood Flow -- Diffusion Imaging -- Other Tissue Parameters -- Functional Brain MRI -- Multinuclear MRI -- Microscopic Imaging -- 4.4.8 Suggested Reading on Applications of Dynamic MRI -- Blood Flow -- Diffusion Imaging -- Other Tissue Parameters -- Functional Brain MRI -- Multinuclear MRI -- Microscopic Imaging -- Chapter 5 Single Photon Emission Computed Tomography -- 5.1 INTRODUCTION -- 5.2 PHYSICAL AND INSTRUMENTATION FACTORS THAT AFFECT SPECT IMAGES -- 5.3 SPECT INSTRUMENTATION -- 5.3.1 SPECT System Designs -- 5.3.2 Special Collimators -- 5.3.3 New Radiation Detector Technologies…”

“…In distributed, open systems like cyberspace, where the behavior of autonomous agents is uncertain and can affect other agents' welfare, trust management is used to allow agents to determine what to expect about the behavior of other agents. …”

“…The story features a Columbo-style detective, Agent Mike McNally, who's investigating the murder of yet another change. …”

“…Plan, Activity, and Intent Recognition explains the crucial role of these techniques in a wide variety of applications including: personal agent assistants computer and network security opponent modeling in games and simulation systems coordination in robots and software agents…”

“…The wide use of multimodal conversational agents exposes the many challenges in achieving more natural, humanlike, and engaging conversational agents…”

“…Presentación del editor: "The Moral Nexus develops and defends a new interpretation of morality--namely, as a set of requirements that connect agents normatively to other persons in a nexus of moral relations. …”

“…You'll then discover how to emulate the vision and hearing capabilities of your agent for natural and humanlike AI behavior, and later improve the agents with the help of graphs. …”

“…Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. …”