| Sumario: | This doctoral thesis by Vivian Leliebre Lara investigates the chemical composition and bioactivity of secondary metabolites from the mushrooms Navisporus floccosus and Trametes versicolor found in Cuba. The study identifies and characterizes the volatile components, fatty acids, and other compounds present in these mushrooms, with a focus on their anti-inflammatory and anti-leishmanial properties. The research highlights the potential therapeutic applications of these metabolites, particularly trametenolic acid B, against the Leishmania amazonensis parasite. The thesis also includes molecular docking studies to understand the interaction between these compounds and the arginase enzyme of the parasite, which is a crucial target for drug development. The work is intended for a scholarly audience, particularly those in the fields of natural products chemistry, pharmacognosy, and parasitology.
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