Handbook on biological warfare preparedness
Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detail...
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| Otros Autores: | , |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
London, England :
Academic Press
[2020]
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| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009835434506719 |
Tabla de Contenidos:
- Front Cover
- Handbook on Biological Warfare Preparedness
- Copyright
- Dedication
- Contents
- Contributors
- Preface
- Acknowledgments
- Chapter 1: Biological warfare agents: History and modern-day relevance
- History of biological warfare agents
- Biological warfare agents
- Characteristics of biological weapons
- Advantages and disadvantages of biological agents
- Characteristics of an ideal biological warfare agent
- Classification of biological warfare agents according to the Center for Disease Control
- Present-day relevance of the agents
- Detection
- Conclusion
- References
- Chapter 2: Bacterial biological warfare agents
- Introduction
- Warfare agents
- Biological warfare agents as a preferred weapon of destruction
- Biological warfare agents
- Bacterial biological warfare agents are unique
- Historical aspects
- Bacterial biological warfare agents
- Lists of bacterial biological warfare agents
- Bacillus anthracis
- Yersinia pestis
- Brucella suis
- Coxiella burnetii
- Francisella tularensis
- Burkholderia pseudomallei
- Burkholderia mallei
- Reason behind rising bacterial bioterrorism
- Identifying the signs of biological attack
- Detection techniques for bacterial biological warfare agents
- Establishment of bacterial biological weapon programs
- Biological warfare program of the USSR
- Japanese biological warfare program
- United States biological warfare program
- Iraq's biological warfare program
- Impact of bacterial bioweaponization for society
- Conclusion
- References
- Chapter 3: Toxins as biological warfare agents
- Introduction
- Dinoflagellate toxins
- Saxitoxin
- Bacterial toxins
- Botulinum neurotoxin
- Staphylococcal enterotoxins
- Staphylococcal enterotoxin B
- Fungal toxins
- Trichothecenes (T-2) toxin
- Diacetoxyscirpenol
- Snail toxins
- Conotoxins.
- Fish toxin
- Tetrodotoxin
- Plant toxins
- Abrin
- Ricin
- Conclusion
- References
- Further Reading
- Chapter 4: Viral agents including threat from emerging viral infections
- Introduction
- Biological warfare agents as a means of terrorism
- Viruses as biological warfare agents
- Historical perspectives
- Viral biological warfare agents
- Variola virus
- Influenza virus
- Filoviruses
- Flaviviruses
- Hantaviruses
- Nipah virus
- Identification of signs of viral attack
- Detection techniques for viral biological warfare agents
- Impact of viral bioterrorism
- Future perspectives
- Conclusion
- References
- Further Reading
- Chapter 5: Advance detection technologies for select biothreat agents
- Introduction
- Bio-detection technologies
- Culture
- Immunological assays
- Immunochromatographic test (ICT)
- Lateral flow rapid strip test
- Flow through spot test
- Molecular assays
- Polymerase chain reaction (PCR)
- Real-time RT-PCR
- Isothermal gene amplification assays
- Next-generation sequencing (NGS) technology
- Biomonitoring
- Aerosol detection technologies
- Sensor technologies
- Nanomaterials biosensors
- Instrumental technologies
- Mass spectrometry
- Raman chemical imaging
- Biodetectors
- Commercially available biodetectors
- Conclusion
- References
- Chapter 6: Microfluidics application for detection of biological warfare agents
- Introduction
- Biological weapons
- Pathogens involved in bioterrorism
- Planning and response
- Preparedness
- Available systems for bioterrorism
- Immunoassays
- Proteomic approaches
- Nucleic acid amplification and detection methods
- Bio-warfare agents monitoring
- Civilian biodefense
- Microfluidic applications in biodefense
- Military biodefense
- Microfluidics
- Types of microfluidics
- Continuous flow microfluidics
- Mixing
- Separation.
- Digital microfluidics
- Droplet-based DMF
- Electrowetting-on-dielectric (EWOD) technique
- Dielectrophoretic technique
- Magnetic-based techniques
- Other techniques
- Liquid-marble-based DMF
- Advanced digital microfluidic platforms
- Various available platforms for bioterrorism
- Nucleic acid-based microfluidic pathogen sensor
- Microfluidic cell-based pathogen sensing
- Microfluidics in combination with mass spectrometry
- Microfluidic pathogen detection systems-based antibody and aptamer sensor
- Microfluidic protein/enzyme based pathogen sensing
- Microfluidics in combination with fluorescence spectrometry
- Microfluidics in combination with electrochemistry
- Conclusion
- References
- Further reading
- Chapter 7: Collection, storage, and transportation of samples for offsite analysis
- Introduction
- Offsite analysis
- Sample collection
- Specimen collection procedures
- Collection of blood samples
- Urine sample collection
- Tissue sample collection
- Saliva/buccal specimen collection
- Nail and hair sample collection
- Precautions to take during sample collection ( International Society for Biological and Environmental Repositories (ISBER) ...
- General guidelines for clinical specimen collection ( Campbell et al., 2012
- De Souza and Greenspan, 2013)
- Packing of clinical samples ( Campbell et al., 2012)
- Storage of samples
- Maintenance of storage systems
- Precautions to be taken before storage of specimens
- Transportation of collected samples
- Conclusion
- Acknowledgments
- References
- Chapter 8: Medical management of diseases associated with biological warfare
- Introduction
- Treatment for bacteria BW agents
- Anthrax
- Mode of transmission
- Treatment
- Vaccine
- Monoclonal antibody
- Case study of anthrax treatment
- Plague
- Mode of transmission
- Treatment
- Vaccine.
- Monoclonal antibodies
- Brucellosis
- Mode of transmission
- Treatment
- Vaccine
- Cholera
- Mode of transmission
- Treatment
- Vaccine
- Melioidosis
- Mode of transmission
- Treatment
- Vaccine
- Tularemia
- Mode of transmission
- Treatment
- Vaccine and monoclonal antibodies
- Treatment for virus BW agents
- Smallpox
- Mode of transmission
- Treatment
- Vaccine
- Crimean-Congo hemorrhagic fever
- Mode of transmission
- Treatment
- Vaccine
- Current research
- Ebola hemorrhagic fever
- Mode of transmission
- Treatment
- Vaccine
- Monoclonal antibodies
- Venezuelan equine encephalitis
- Mode of transmission
- Treatment
- Vaccine
- Current research
- Treatment for toxins BW agents
- Saxitoxin
- Mode of transmission
- Treatments
- Botulinum toxin
- Mode of transmission
- Treatment for botulinum toxin
- Ricin
- Mode of transmission
- Treatment for ricin poisoning
- Conclusion
- References
- Chapter 9: Protective equipment for protection against biological warfare agents
- Introduction
- Classification of biological warfare agents and their symptoms
- Routes of exposure and modes of delivery
- Why there is need of protection?
- Principles of body and respiratory protection
- Individual protection
- Respiratory protection
- Gas filter
- Air-supplying devices
- Body protection
- NBC suit
- Impermeable NBC suit:
- Permeable NBC suit:
- Recent developments in IPE:
- Integrated hood mask
- Facelet mask
- Impermeable overboots
- Impermeable gloves
- Testing and classification of commercially available BWA suits
- Collective protection
- Level of protection
- Performance requirement of protective clothing and facemask against BWA
- Protection through vaccine and antibiotics
- Materials used for the fabrication of IPEs
- State-of-the-art products available for protection.
- Outlook, prospects, and challenges
- References
- Chapter 10: Environmental sampling and bio-decontamination-Recent progress, challenges, and future direction
- Introduction and background
- Environmental bio-sampling
- Infrastructure decontamination
- Challenges
- Future research directions
- Conclusions and closing remarks
- References
- Chapter 11: Biological and toxin warfare convention: Current status and future prospects
- The imminent danger
- The convention
- The BWC, its expeditions, plights, and current status
- Lack of agreement
- Unachieved universality
- Lack of compliance and related verification
- Implementation challenges
- The future of the convention
- References
- Chapter 12: Next generation agents (synthetic agents): Emerging threats and challenges in detection, protection, and decon ...
- Potential biological weapons and warfare agents
- A brief history of biological warfare
- Emergence of next generation biological weapons
- Binary biological weapons
- Designer genes
- Designer diseases
- Gene therapy based bioweapons
- Host swapping diseases
- Stealth viruses
- Synthetic biology assisted whole genome synthesis of bacterial clones and bacteriophages
- Synthesis of bacteriophage φ X174
- Synthesis bacteriophage T7 genome by refactoring process
- Synthesis of M. genitalium and M. mycoides clones using minimal genome content
- Synthetic biology assisted whole genome synthesis of native or chimeric viruses
- Synthesis of the 1918 Spanish flu virus
- Synthesis of poliovirus
- Synthesis of human endogenous retrovirus
- Synthesis of HIVcpz
- Synthesis of SARS-like coronavirus
- In vitro packaging of viral genomes
- Mechanism for dsRNA viral genome packaging
- Mechanism for dsDNA viral genome packaging
- Mechanism of linear motor assisted viral genome packaging.
- Mechanism of rotary motor assisted viral genome packaging.
