Updated Recommendations on Treatment of Adolescents and Children with Chronic HCV Infection, and HCV Simplified Service Delivery and HCV Diagnostics

Updated Recommendations on Treatment of Adolescents and Children with Chronic HCV Infection, and HCV Simplified Service Delivery and HCV Diagnostics

This publication from the World Health Organization provides updated guidelines on the treatment of adolescents and children with chronic Hepatitis C Virus (HCV) infection. It details the simplified service delivery models for HCV testing, care, and treatment, emphasizing a public health approach. T...

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Detalles Bibliográficos
Formato: Libro electrónico
Idioma:Inglés
Publicado: Geneva : World Health Organization 2022.
Edición:1st ed
Materias:
Hepatitis C.
Child health services.
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009820537506719
Tabla de Contenidos:
  • Intro
  • ACKNOWLEDGEMENTS
  • ABBREVIATIONS AND ACRONYMS
  • GLOSSARY OF TERMS
  • EXECUTIVE SUMMARY
  • chapter 1. INTRODUCTION
  • 1.1 Objectives and scope of updated HCV guidelines
  • 1.2 Related guidelines
  • 1.3 Intended audience
  • 1.4 Guiding principles
  • chapter 2. BACKGROUND - EPIDEMIOLOGY AND NATURAL HISTORY
  • 2.1 Epidemiology of hepatitis C virus infection and the challenge of HCV elimination
  • 2.2 Natural history of HCV infection
  • 2.3 Routes of transmission
  • 2.4 Direct-acting antivirals
  • chapter 3. METHODOLOGY AND PROCESS OF DEVELOPING THE GUIDELINES
  • 3.2 WHO guideline development process (Web Annex 1)
  • 3.3 Roles
  • 3.4 Evidence that informed the recommendations
  • 3.5 Grading of certainty of evidence and strength of recommendations
  • 3.6 Formulation of recommendations
  • 3.7 Declarations of interest and management of conflicts of interest
  • 3.8 Dissemination and updating of the guidelines
  • TREATMENT IN ADULTS, ADOLESCENTS AND CHILDREN
  • CHAPTER 4. TREATMENT FOR ADULTS, ADOLESCENTS AND CHILDREN (≥3 YEARS)
  • 4.1 New recommendations: Treatment of adolescents (12-17 years), older children (6-11 years) and younger children (3-5 years) and Existing 2018 recommendations for adults
  • 4.2 Background
  • 4.3 Summary of the evidence for treatment in adolscents and children (Web Annex 4A)
  • 4.4 Rationale for the recommendations
  • 4.5 Implementation considerations
  • 4.6 Research gaps
  • SIMPLIFIED SERVICE DELIVERY FOR A PUBLIC HEALTH APPROACH TO HCV TESTING, CARE AND TREATMENT
  • CHAPTER 5. DECENTRALIZATION AND INTEGRATION
  • 5.1 Recommendations: Decentralized and integrated HCV testing and treatment services
  • 5.2 Background
  • 5.3 Summary of evidence (Web Annex 5A)
  • 5.4 Rationale for recommendation
  • 5.5 Implementation considerations
  • 5.6 Research gaps
  • CHAPTER 6. TASK SHARING
  • 6.1 Recommendation: task sharing.
  • 6.2 Background
  • 6.3 Summary of the evidence (Web Annex 5A)
  • 6.4 Rationale for the recommendations
  • 6.5 Implementation considerations
  • 6.6 Existing additional good practice principles for simplified service delivery (from 2018 HCV treatment guidelines)
  • CHAPTER 7. IMPROVING THE UPTAKE OF TESTING AND LINKAGE TO CARE
  • 7.1 Summary of existing and new recommendations on improving uptake of testing and linkage to care
  • 7.2 Background
  • 7.3 Summary of the evidence for three 2017 recommendations to promote testing and linkage
  • 7.4 Rationale for the 2017 recommendations for three strategies to promote testing and linkage
  • 7.5 Implementation considerations
  • HCV DIAGNOSTICS
  • CHAPTER 8. DETECTION OF VIRAEMIC HCV INFECTION TO GUIDE TREATMENT - New recommendations
  • 8.1 Existing and new recommendations on detection of HCV viraemic infection
  • 8.2 Background
  • 8.3 Summary of evidence - POC HCV RNA NAT assays
  • 8.4 Rationale for the recommendations - POC HCV RNA NAT assays
  • 8.5 Summary of the evidence - laboratory-based HCV RNA NAT assays from 2017 hepatitis testing guidelines (4)
  • 8.6 Rationale for the recommendations - lab-based HCV RNA assays
  • 8.7 Implementation considerations for POC HCV RNA and laboratory-based HCV RNA assays
  • 8.8 Research gaps
  • CHAPTER 9. ASSESSMENT OF HCV TREATMENT RESPONSE - TEST OF CURE
  • 9.1 Existing and new recommendations on assessment of HCV treatment response
  • 9.2 Background
  • 9.3 Summary of the evidence
  • 9.4 Rationale for the recommendations
  • 9.5 Implementation considerations
  • 9.6 Research gaps
  • CHAPTER 10. LABORATORY-BASED REFLEX TESTING AND REFLEX SAMPLE COLLECTION FOR HCV VIRAEMIA
  • 10.1 New recommendation on reflex HCV RNA testing
  • 10.2 Background
  • 10.3 Summary of the evidence (Web Annex 10A1 and 10A2)
  • 10.4 Rationale for the recommendations.
  • 10.5 Implementation considerations
  • References.

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