Advances in understanding genetic changes in cancer : impact on diagnosis and treatment decisions in the 1990s : a research briefing from the Division of Health Sciences Policy, Institute of Medicine

Advances in understanding genetic changes in cancer impact on diagnosis and treatment decisions in the 1990s : a research briefing from the Division of Health Sciences Policy, Institute of Medicine

Detalles Bibliográficos
Autor Corporativo: Institute of Medicine (U.S.). Division of Health Sciences Policy (-)
Formato: Libro electrónico
Idioma:Inglés
Publicado: Washington, D.C. : National Academy Press 1992.
Edición:1st ed
Materias:
Cancer > Genetic aspects.
Cancer > Research > United States.
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009820339506719
Tabla de Contenidos:
  • ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER
  • Copyright
  • Statement of Purpose
  • Contents
  • ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER
  • 1 Introduction
  • OUTLINE OF MOLECULAR GENETICS
  • BRIEF OVERVIEW OF CANCER GENETICS
  • 2 Testing for Tumor-Specific Genetic Markers
  • MICROSCOPIC DETECTION OF ALTERATIONS IN DNA STRUCTURE
  • In Situ Hybridization
  • Ploidy Analysis
  • TECHNIQUES FOR DETECTING CHANGES IN DNA STRUCTURE AT THE SUBMICROSCOPIC LEVEL
  • Southern Blot Hybridization
  • Pulsed-Field Gel Electrophoresis
  • Polymerase Chain Reaction
  • TECHNIQUES FOR DETECTION OF POINT MUTATIONS IN DNA
  • TECHNIQUES DIRECTED AT ANALYSIS OF RNA
  • TECHNIQUES FOR ANALYZING CHANGES AT THE PROTEIN LEVEL
  • Immunohistochemistry
  • 3 Hematologic Cancer
  • CHRONIC MYELOGENOUS LEUKEMIA
  • CHRONIC LYMPHOCYTIC LEUKEMIA
  • ACUTE LYMPHOCYTIC LEUKEMIA
  • ACUTE MYELOGENOUS LEUKEMIA
  • MYELODYSPLASTIC SYNDROMES
  • LYMPHOMA
  • 4 Solid Tumors
  • CHROMOSOMAL ABERRATIONS OF DIAGNOSTIC IMPORTANCE
  • CHROMOSOMAL ABERRATIONS OF PROGNOSTIC IMPORTANCE
  • Neuroblastoma
  • Breast Cancer
  • Lung Cancer
  • Other Solid Tumors
  • GENETIC MARKERS OF PREDISPOSITION TO CANCER
  • Retinoblastoma
  • Mapping of Other Cancer Predisposition Loci
  • Li-Fraumeni Syndrome
  • Loss of Heterozygosity in Sporadic Solid Tumors
  • GENETIC CHANGES AND TUMOR PROGRESSION
  • Colorectal Neoplasms
  • Glial Tumors
  • CANCER-ASSOCIATED GENETIC CHANGES AND ENVIRONMENTAL MUTAGENS
  • VIRAL MARKERS IN CANCER DIAGNOSIS
  • 5 Summary and Specific Recommendations
  • PRACTICAL ASPECTS OF GENETIC ANALYSIS: FROM PATIENT TO DIAGNOSTIC LABORATORY
  • THE MOLECULAR DIAGNOSTIC LABORATORY
  • IMPLICATIONS OF COMMERCIALIZATION
  • FUTURE NEEDS
  • 6 References.

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