Assessment of future scientific needs for live variola virus
| Autor Corporativo: | |
|---|---|
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Washington, D.C. :
National Academy Press
1999.
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| Edición: | 1st ed |
| Colección: | Compass series (Washington, D.C.)
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| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009820329006719 |
Tabla de Contenidos:
- Assessment of Future Scientific Needs for Live Variola Virus
- Copyright
- Preface
- Acknowledgments
- REVIEWERS
- Contents
- Executive Summary
- SCOPE
- SCIENTIFIC NEEDS FOR LIVE AND REPLICATION-DEFECTIVE VARIOLA VIRUS
- OVERALL CONCLUSIONS
- Part I Introduction
- 1 Introduction
- BACKGROUND
- CONTEMPORARY CONTEXT
- SCOPE
- SCIENTIFIC NEEDS FOR VARIOLA VIRUS
- ORGANIZATION OF THIS REPORT
- Part II Smallpox and Its Control
- 2 Variola Virus and Other Orthopoxviruses
- GENERAL ATTRIBUTES OF ORTHOPOXVIRUSES
- POXVIRUS REPLICATION
- PROPERTIES OF SPECIFIC ORTHOPOXVIRUSES
- 3 Clinical Features of Smallpox
- ENTRY AND INFECTION
- DISSEMINATION
- THE RASH
- LESIONS OF THE MUCOUS MEMBRANES
- EFFECTS ON OTHER ORGANS
- IMMUNE RESPONSE
- IMMUNITY AGAINST SMALLPOX
- 4 Epidemiology
- CHARACTERISTICS OF HISTORICAL OUTBREAKS
- LIKELY CHARACTERISTICS OF FUTURE SMALLPOX OUTBREAKS
- CONTROL STRATEGIES
- 5 Variola Virus Stocks Following Eradication of Smallpox
- ESTABLISHMENT OF INTERNATIONAL REPOSITORIES
- DECISION BY THE WORLD HEALTH ASSEMBLY TO DESTROY VARIOLA VIRUS STOCKS
- U.S. RESEARCH ON SMALLPOX
- RESEARCH AT CDC AND USAMRIID
- Part III Scientific Needs for Variola Virus
- 6 Development of Antiviral Agents
- IN VITRO ASSAYS
- ANIMAL MODELS
- 7 Development of Vaccines
- CURRENT STATUS OF VACCINIA VACCINE PREPARATIONS
- EVALUATION OF VACCINIA VACCINE DERIVED FROM TISSUE CULTURE
- EVALUATION OF NOVEL VACCINES
- 8 Detection and Diagnosis
- ENVIRONMENTAL DETECTION
- DIAGNOSIS OF INFECTION
- ALTERNATIVES TO LIVE VIRUS
- 9 Bioinformatics
- VARIABILITY OF VARIOLA VIRUS
- POTENTIAL DEVELOPMENTS
- 10 Understanding of the Biology of Variola Virus
- VIRUS-CELL INTERACTIONS
- VIRUS-HOST INTERACTIONS
- 11 Research on the Expressed Protein Products of Variola
- SYNTHESIS OF VARIOLA PROTEINS.
- POTENTIAL UTILITY OF VARIOLA PROTEINS
- Part IV Findings
- 12 Summary and Conclusions
- THE BROADER CONTEXT
- SCIENTIFIC NEEDS FOR LIVE VARIOLA VIRUS
- OVERALL CONCLUSIONS
- References
- Appendix A Glossary
- Appendix B Acronyms
- Appendix C Committee and Staff Biographies
- Staff.
