Smokeless tobacco and some tobacco-specific N-nitrosamines

Smokeless tobacco and some tobacco-specific N-nitrosamines

This eighty-ninth volume of the IARC Monographs is the third and last of a series on tobacco-related agents. Volume 83 reported on the carcinogenicity of tobacco smoke and involuntary smoking (second-hand smoke or environmental tobacco smoke) (IARC 2004a). Volume 85 summarized the evidence on the ca...

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Bibliographic Details
Main Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.
Corporate Authors: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Meeting (-), International Agency for Research on Cancer
Format: eBook
Language:Inglés
Published: Lyon, France : Geneva : World Health Organization, International Agency for Research on Cancer ; distributed by WHO Press 2007.
Series:IARC monographs on the evaluation of carcinogenic risks to humans ; v. 89.
Subjects:
Smokeless tobacco > Toxicology > Congresses.
Smokeless tobacco > Composition > Congresses.
Carcinogens > Dose-response relationship > Congresses.
Nitrosoamines > Carcinogenicity > Congresses.
See on Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009820293706719
Table of Contents:
  • Intro
  • CONTENTS
  • NOTE TO THE READER
  • LIST OF PARTICIPANTS
  • PREAMBLE
  • 1. Background
  • 2. Objective and Scope
  • 3. Selection of Topics for Monographs
  • 4. Data for Monographs
  • 5. The Working Group
  • 6. Working Procedures
  • 7. Exposure Data
  • 8. Studies of Cancer in Humans
  • 9. Studies of Cancer in Experimental Animals
  • 10. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms
  • 11. Summary of Data Reported
  • 12. Evaluation
  • 13. References
  • GENERAL REMARKS
  • THE MONOGRAPHS
  • Smokeless Tobacco
  • 1. Description of Smokeless Tobacco Practices
  • 1.1 Historical overview
  • 1.2 Manufacture and use of smokeless tobacco products
  • 1.3 Chemical composition of smokeless tobacco
  • 1.4 Production, consumption and prevalence of use of smokeless tobacco products
  • 1.5 Regulations
  • 2. Studies of Cancer in Humans
  • 2.1 Introduction
  • 2.2 Oral use
  • 2.3 Nasal use
  • 3. Studies of Cancer in Experimental Animals
  • 3.1 Tobacco
  • 3.2 Snuff tobacco
  • 3.3 Bidi tobacco, mishri and naswar
  • 4. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms
  • 4.1 Absorption, distribution, metabolism and excretion
  • 4.2 Toxic effects
  • 4.3 Reproductive, developmental and hormonal effects
  • 4.4 Genetic and related effects
  • 4.5 Mechanistic considerations
  • 5. Summary of Data Reported and Evaluation
  • 5.1 Exposure data
  • 5.2 Human carcinogenicity data
  • 5.3 Animal carcinogenicity data
  • 5.4 Other relevant data
  • 5.5 Evaluation
  • 6. References
  • Some Tobacco-specific N-Nitrosamines
  • 1. Exposure Data
  • 1.1 Chemical and physical data (by compound)
  • 1.2 Technical products and impurities, analysis, production and use
  • 1.3 Occurrence
  • 1.4 Biomonitoring in saliva, urine and other tissues
  • 2. Studies of Cancer in Humans
  • 3. Studies of Cancer in Experimental Animals.
  • 3.1 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
  • 3.2 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
  • 3.3 N′-Nitrosonornicotine (NNN)
  • 3.4 N′-Nitrosoanabasine (NAB)
  • 3.5 N′-Nitrosoanatabine (NAT)
  • 4. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanism
  • 4.1 Absorption, distribution, metabolism and excretion
  • 4.2 Toxic effects
  • 4.3 Reproductive and developmental effects
  • 4.4 Genetic and related effects
  • 4.5 Mechanistic considerations
  • 5. Summary of Data Reported and Evaluation
  • 5.1 Exposure data
  • 5.2 Human carcinogenicity data
  • 5.3 Animal carcinogenicity data
  • 5.4 Other relevant data
  • 5.5 Evaluation
  • 6. References
  • GLOSSARY
  • LIST OF ABBREVIATIONS
  • CUMULATIVE INDEX TO THE MONOGRAPHS SERIES.

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