Coupled enzyme activity and thermal shift screening of the Maybridge Rule of 3 Fragment Library against Trypanosoma brucei choline kinase, a genetically validated drug target

Coupled enzyme activity and thermal shift screening of the Maybridge Rule of 3 Fragment Library against Trypanosoma brucei choline kinase, a genetically validated drug target

In this study the authors interrogate ~630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse [35, 36], pharmacophoric rich, chemical entities. Comparisons be...

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Detalles Bibliográficos
Otros Autores: Major, Louise L., author (author), Denton, Helen, author, Smith, Terry K., author
Formato: Seriada digital
Idioma:Inglés
Publicado: Rijeka (HR) : InTech 2013.
Materias:
Fluorimetry.
Trypanosoma.
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009820258006719
Tabla de Contenidos:
  • 14. Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target
  • Louise L. Major, Helen Denton, and Terry K. Smith.
  • 1. Introduction
  • 2. Experimental
  • 3. Results and discussion
  • 4. Conclusions
  • Acknowledgements
  • References.

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