RNA damage and repair
| Otros Autores: | |
|---|---|
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Cham, Switzerland :
Springer
[2021]
|
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009820243506719 |
Tabla de Contenidos:
- Intro
- Preface
- Contents
- Part I: RNA Damage and Repair in Prokaryotes
- Endoribonucleases of the Toxin-Antitoxin Systems Induce Abortive Infection
- 1 Introduction
- 1.1 The Arms Race Between Bacteria and Phages
- 1.2 The Abortive Infection (Abi) System
- 1.3 The Toxin-Antitoxin (TA) System
- 2 Functions, Structures, and Regulation of the MazF Endoribonuclease
- 2.1 The Abortive Infection Induced by the MazF Endoribonuclease
- 2.2 Phage Mechanism to Overcome MazF-Induced Abi
- 3 Functions, Structures, and Regulation of RnlA Endoribonuclease
- 3.1 The Abortive Infection Induced by RnlA Endoribonuclease
- 3.2 Phage Mechanisms to Overcome RnlA-Induced Abi
- 4 Functions, Structures, and Regulations of ToxN Endoribonuclease
- 4.1 The Abortive Infection Induced by ToxN Endoribonuclease
- 4.2 Phage Mechanisms to Overcome ToxN-Induced Abi
- 5 Conclusion
- References
- The Lifecycle of Ribosomal RNA in Bacteria
- 1 Introduction
- 2 Localisation and Copy Number of rDNA Operons in Bacteria
- 3 Organisation of rDNA Operons in Bacteria
- 4 Transcription Regulation of rDNA Genes Along the Microbial Growth Curve
- 4.1 Ribosomal DNA Promoters and Cis-Regulatory Elements
- 4.2 Trans-regulatory Elements
- 4.2.1 Regulation by Transcription Factors
- 4.2.2 Regulation by NTP and (p)ppGpp
- 5 Processing of Premature rRNA into Functional rRNAs
- 5.1 Maturation of 23S rRNA in E. coli
- 5.2 Maturation of 16S rRNA in E. coli
- 5.3 Maturation of 5S rRNA in E. coli
- 6 Bacterial rRNA Fragmentation
- 7 Chemical Modification of rRNA Molecules
- 8 Assembly of rRNAs into Ribosomes
- 9 rRNA Quality Control
- 10 Damage and Repair of Bacterial rRNA
- 11 Conclusion
- References
- The Rtc RNA End Healing and Sealing System
- 1 Introduction
- 2 Biological RNA Damage
- 2.1 CRISPR-Cas Systems
- 3 RNA Repair
- 4 The RtcA and RtcB Enzymes.
- 4.1 The RtcA RNA Cyclase
- 4.2 The RtcB RNA Ligase
- 4.3 The RtcB RNA Ligase in Prokaryotes
- 4.4 The RtcB RNA Ligase in Metazoans
- 5 The Bacterial Rtc RNA Repair System
- 5.1 Diversity of the rtc Operon in Bacteria
- 5.2 The RtcR Transcriptional Regulator and Its CARF Domain
- 5.3 Expression and Function of the Rtc System in Bacteria
- 6 Conclusions
- References
- Part II: RNA Damage and Repair in Eukaryotes
- Oxidative and Nitrative RNA Modifications in Plants
- 1 Introduction
- 2 Oxidative Modifications of RNA in Plants
- 3 Nitrative Modifications of RNA in Plants
- 4 Conclusions
- References
- The Role of Ribonucleases in RNA Damage, Inactivation and Degradation
- 1 Introduction
- 2 Quality Control Mechanisms to Manage Damaged RNA
- 3 Ribosome Quality Control (RQC) and No-Go-Decay (NGD)
- 4 Xrn1, a 5'-3' Exoribonuclease, and the Exosome, a 3'-5' Exoribonuclease Complex
- 5 Cue2 as a Potential NGD Endonuclease
- 6 The Role of Ribonucleases in Targeting and Inactivating Host and Foreign RNA
- 7 Regulatory RNase 1 (Regnase-1)
- 8 NEDD4-Binding Protein 1 (N4BP1)
- 9 Zinc Finger Antiviral Protein (ZAP) and Co-Factor Nucleases
- 10 ZAP and KHNYN
- 11 ZAP and the Exosome Complex
- 12 The 2',5'-Oligoadenylate Synthetase (OAS)/RNAse L System
- 13 Conclusion
- References
- Cytoplasmic mRNA Recapping: An Unexpected Form of RNA Repair
- 1 The Nature of the Cap and Its Role in mRNA Metabolism
- 2 Decapping and 5' Decay
- 3 Early Evidence for Uncapped and Recapped Transcripts
- 4 The Discovery of Cytoplasmic Capping
- 5 The Proteins of the Cytoplasmic Capping Complex
- 6 Cap Homeostasis as an RNA Repair Mechanism That Modulates Translation, mRNA Decay, and Translational Control
- 7 Is There a Relationship Between Recapped Ends and CAGE Tags?
- 8 Does Cytoplasmic Capping Impact the Proteome?.
- 9 Conclusion and Future Questions
- References
- Part III: RNA Damage in Human Diseases
- Adenosine-to-Inosine RNA Editing: A Key RNA Processing Step Rewriting Transcriptome in Normal Physiology and Diseases
- 1 Regulatory Mechanisms of A-to-I RNA Editing
- 1.1 Editing Regulation by Altering ADAR Expression and Activity
- 1.2 Editing Regulation by Affecting Subcellular Localization of ADAR
- 1.3 Additional Layers of A-to-I RNA Editing Regulation
- 2 Cross Talk of RNA Editing with Other RNA Processing and Cellular Pathways
- 2.1 Roles of ADARs and RNA Editing in miRNA Targeting and Biogenesis
- 2.2 ADARs and Splicing Regulation
- 2.3 ADAR Directly Promotes Proximal Polyadenylation Site
- 2.4 ADAR and N6-Methyladenosine
- 2.5 ADAR and Apoptosis
- 2.6 ADAR and Innate Immunity
- 2.7 ADAR2 and Circadian Rhythm
- References
- RNA-Mediated Metabolic Defects in Microsatellite Expansion Diseases
- 1 Overview of Microsatellite Expansion Diseases
- 2 RNA Structure and RNA-Mediated Toxicity
- 3 Repeat Associated Non-AUG Translation
- 4 Emerging Pathological Roles of microRNA
- 5 Defects in Nucleocytoplasmic Transport
- 6 Liquid-Liquid Phase Separation (LLPS) and Stress Granules
- 7 Conclusions and Future Perspectives
- References.
