Genetic analysis : an integrated approach

Genetic analysis an integrated approach

For all introductory genetics courses Informed by many years of genetics teaching and research expertise, authors Mark Sanders and John Bowman use an integrated approach that helps contextualize three core challenges of learning genetics: solving problems, understanding evolution, and understanding...

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Detalles Bibliográficos
Otros Autores: Sanders, Mark Frederick, author (author), Bowman, John L., author
Formato: Libro electrónico
Idioma:Inglés
Publicado: Boston : Pearson [2016]
Edición:Seventh, global edition
Colección:Always learning.
Materias:
Genetics > Technique.
Libros electrónicos.
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009767235606719
Tabla de Contenidos:
  • Cover
  • Brief Table of Contents
  • Table of Contents
  • About the Authors
  • Dedication
  • Preface
  • Unit I : Gene Transmission and Function
  • Chapter 1: The Molecular Basis of Heredity, Variation, and Evolution
  • 1.1 Modern Genetics is in its Second Century
  • The First Century of Modern Genetics
  • Genetics-Central to Modern Biology
  • 1.2 The Structure of DNA Suggests a Mechanism for Replication
  • The Discovery of DNA Structure
  • DNA Nucleotides
  • DNA Replication
  • 1.3 DNA Transcription and Messenger RNA Translation Express Genes
  • Genetic Analysis 1.1
  • Transcription
  • Experimental Insight 1.1
  • Translation
  • Genomes, Proteomes, and "-omic" Approaches
  • Genetic Analysis 1.2
  • 1.4 Evolution Has a Molecular Basis
  • Darwin's Theory of Evolution
  • Four Evolutionary Processes
  • Tracing Evolutionary Relationships
  • Genetic Analysis 1.3
  • Case Study: The Modern Human Family
  • Summary
  • Keywords
  • Problems
  • Chapter 2: Transmission Genetics
  • 2.1 Gregor Mendel Discovered the Basic Principles of Genetic Transmission
  • Mendel's Modern Experimental Approach
  • Five Critical Experimental Innovations
  • 2.2 Monohybrid Crosses Reveal the Segregation of Alleles
  • Identifying Dominant and Recessive Traits
  • Evidence of Particulate Inheritance and Rejection of the Blending Theory
  • Segregation of Alleles
  • Hypothesis Testing by Test-Cross Analysis
  • Hypothesis Testing by F2 Self-Fertilization
  • 2.3 Dihybrid and Trihybrid Crosses Reveal the Independent Assortment of Alleles
  • Dihybrid-Cross Analysis of Two Genes
  • Genetic Analysis 2.1
  • Testing Independent Assortment by Test-Cross Analysis
  • Genetic Analysis 2.2
  • Testing Independent Assortment by Trihybrid-Cross Analysis
  • Probability Calculations in Genetics Problem Solving
  • The Rediscovery of Mendel's Work
  • Genetic Analysis 2.3
  • Experimental Insight 2.1.
  • 2.4 Probability Theory Predicts Mendelian Ratios
  • The Product Rule
  • Experimental Insight 2.2
  • The Sum Rule
  • Conditional Probability
  • Experimental Insight 2.3
  • Binomial Probability
  • 2.5 Chi-Square Analysis Tests the Fit between Observed Values and Expected Outcomes
  • The Normal Distribution
  • Chi-Square Analysis
  • Chi-Square Analysis of Mendel's Data
  • 2.6 Autosomal Inheritance and Molecular Genetics Parallel the Predictions of Mendel's Hereditary Principles
  • Autosomal Dominant Inheritance
  • Autosomal Recessive Inheritance
  • Molecular Genetics of Mendel's Traits
  • Case Study: Inheritance of Sickle Cell Disease in Humans
  • Summary
  • Keywords
  • Problems
  • Chapter 3: Cell Division and Chromosome Heredity
  • 3.1 Mitosis Divides Somatic Cells
  • Stages of the Cell Cycle
  • Substages of M Phase
  • Chromosome Distribution
  • Completion of Cell Division
  • Cell Cycle Checkpoints
  • Cell Cycle Mutations and Cancer
  • 3.2 Meiosis Produces Gametes for Sexual Reproduction
  • Meiosis versus Mitosis
  • Meiosis I
  • Meiosis II
  • The Mechanistic Basis of Mendelian Ratios
  • Segregation in Single-Celled Diploids
  • 3.3 The Chromosome Theory of Heredity Proposes that Genes are Carried on Chromosomes
  • Genetic Analysis 3.1
  • X-Linked Inheritance
  • Testing the Chromosome Theory of Heredity
  • 3.4 Sex Determination Is Chromosomal and Genetic
  • Sex Determination in Drosophila
  • Genetic Analysis 3.2
  • Mammalian Sex Determination
  • Diversity of Sex Determination
  • Experimental Insight 3.1
  • 3.5 Human Sex-Linked Transmission Follows Distinct Patterns
  • Expression of X-Linked Recessive Traits
  • Genetic Analysis 3.3
  • X-Linked Dominant Trait Transmission
  • Y-Linked Inheritance
  • 3.6 Dosage Compensation Equalizes the Expression of Sex-Linked Genes
  • Case Study: The (Degenerative) Evolution of the Mammalian Y Chromosome
  • Summary.
  • Keywords
  • Problems
  • Chapter 4: Inheritance Patterns of Single Genes and Gene Interaction
  • 4.1 Interactions between Alleles Produce Dominance Relationships
  • The Molecular Basis of Dominance
  • Functional Effects of Mutation
  • Incomplete Dominance
  • Codominance
  • Dominance Relationships of ABO Alleles
  • Allelic Series
  • Genetic Analysis 4.1
  • Lethal Alleles
  • Sex-Limited Traits
  • Sex-Influenced Traits
  • Delayed Age of Onset
  • 4.2 Some Genes Produce Variable Phenotypes
  • Incomplete Penetrance
  • Variable Expressivity
  • Gene-Environment Interactions
  • Pleiotropic Genes
  • 4.3 Gene Interaction Modifies Mendelian Ratios
  • Gene Interaction in Pathways
  • The One Gene-One Enzyme Hypothesis
  • Genetic Dissection to Investigate Gene Action
  • Experimental Insight 4.1
  • Epistasis and Its Results
  • Genetic Analysis 4.2
  • 4.4 Complementation Analysis Distinguishes Mutations in the Same Gene from Mutations in Different Genes
  • Genetic Analysis 4.3
  • Case Study: Complementation Groups in a Human Cancer-Prone Disorder
  • Summary
  • Keywords
  • Problems
  • Chapter 5: Genetic Linkage and Mapping in Eukaryotes
  • 5.1 Linked Genes Do Not Assort Independently
  • Indications of Genetic Linkage
  • The Discovery of Genetic Linkage
  • Detecting Autosomal Genetic Linkage through Test-Cross Analysis
  • Genetic Analysis 5.1
  • 5.2 Genetic Linkage Mapping is Based on Recombination Frequency between Genes
  • The First Genetic Linkage Map
  • Map Units
  • Chi-Square Analysis of Genetic Linkage Data
  • 5.3 Three-Point Test-Cross Analysis Maps Genes
  • Finding the Relative Order of Genes by Three-Point Mapping
  • Constructing a Three-Point Recombination Map
  • Determining Gamete Frequencies from Genetic Maps
  • 5.4 Recombination Results from Crossing Over
  • Cytological Evidence of Recombination
  • Limits of Recombination along Chromosomes.
  • Recombination within Genes
  • Genetic Analysis 5.2
  • Biological Factors Affecting Accuracy of Genetic Maps
  • Recombination Is Dominated by Hotspots
  • Correction of Genetic Map Distances
  • 5.5 Linked Human Genes are Mapped Using Lod Score Analysis
  • Allelic Phase
  • Lod Score Analysis
  • Experimental Insight 5.1
  • Genetic Analysis 5.3
  • 5.6 Recombination Affects Evolution and Genetic Diversity
  • 5.7 Genetic Linkage in Haploid Eukaryotes is Identified by Tetrad Analysis
  • Analysis of Unordered Tetrads
  • Ordered Ascus Analysis
  • 5.8 Mitotic Crossover Produces Distinctive Phenotypes
  • Case Study: Mapping the Gene for Cystic Fibrosis
  • Summary
  • Keywords
  • Problems
  • Chapter 6: Genetic Analysis and Mapping in Bacteria and Bacteriophages
  • 6.1 Bacteria Transfer Genes by Conjugation
  • Characteristics of Bacterial Genomes
  • Conjugation Identified
  • Research Technique 6.1
  • Transfer of the F Factor
  • Formation of an Hfr Chromosome
  • Hfr Gene Transfer
  • 6.2 Interrupted Mating Analysis Produces Time-of-Entry Maps
  • Time-of-Entry Mapping Experiments
  • Consolidation of Hfr Maps
  • Genetic Analysis 6.1
  • 6.3 Conjugation with F' Strains Produces Partial Diploids
  • Plasmids and Conjugation in Archaea
  • 6.4 Bacterial Transformation Produces Genetic Recombination
  • Genetic Analysis 6.2
  • Steps in Transformation
  • Mapping by Transformation
  • 6.5 Bacterial Transduction is Mediated by Bacteriophages
  • Bacteriophage Life Cycles
  • Generalized Transduction
  • Cotransduction
  • Cotransduction Mapping
  • Specialized Transduction
  • 6.6 Bacteriophage Chromosomes are Mapped by Fine-Structure Analysis
  • Genetic Analysis 6.3
  • Genetic Complementation Analysis
  • Intragenic Recombination Analysis
  • Deletion-Mapping Analysis
  • 6.7 Lateral Gene Transfer Alters Genomes
  • Lateral Gene Transfer and Genome Evolution.
  • Identifying Lateral Gene Transfer in Genomes
  • Case Study: The Evolution of Antibiotic Resistance and Change in Medical Practice
  • Summary
  • Keywords
  • Problems
  • Unit II: Central Dogma
  • Chapter 7: DNA Structure and Replication
  • 7.1 DNA is the Hereditary Molecule of Life
  • Chromosomes Contain DNA
  • A Transformation Factor Responsible for Heredity
  • DNA is the Transformation Factor
  • 7.2 The DNA Double Helix Consists of Two Complementary and Antiparallel Strands
  • DNA Nucleotides
  • Genetic Analysis 7.1
  • Complementary DNA Nucleotide Pairing
  • The Twisting Double Helix
  • 7.3 DNA Replication is Semiconservative and Bidirectional
  • Three Competing Models of Replication
  • The Meselson-Stahl Experiment
  • Origin and Directionality of Replication in Bacterial DNA
  • Multiple Replication Origins in Eukaryotes
  • 7.4 DNA Replication Precisely Duplicates the Genetic Material
  • DNA Sequences at Replication Origins
  • Replication Initiation
  • Continuous and Discontinuous Strand Replication
  • RNA Primer Removal and Okazaki Fragment Ligation
  • Simultaneous Synthesis of Leading and Lagging Strands
  • DNA Proofreading
  • Finishing Replication
  • Genetic Analysis 7.2
  • Telomeres, Aging, and Cancer
  • 7.5 Molecular Genetic Analytical Methods Make Use of DNA Replication Processes
  • The Polymerase Chain Reaction
  • Separation of PCR Products
  • Dideoxynucleotide DNA Sequencing
  • New DNA-Sequencing Technologies: Next Generation and Third Generation
  • Genetic Analysis 7.3
  • Case Study: Use of PCR and DNA Sequencing to Analyze Huntington Disease Mutations
  • Summary
  • Keywords
  • Problems
  • Chapter 8: Molecular Biology of Transcription and RNA Processing
  • 8.1 RNA Transcripts Carry the Messages of Genes
  • RNA Nucleotides and Structure
  • Identification of Messenger RNA
  • RNA Classification.
  • 8.2 Bacterial Transcription is a Four-Stage Process.

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