Using the Patch-Clamp technique to shed light on ion channels structure, function and pharmacology
Ion channels are membrane proteins that selectively allow ions to flow down their electrochemical gradient across the cellular membrane. They localize in both plasma and intracellular membranes and regulate a variety of functions such as neuronal excitability, heartbeat, muscle contraction and hormo...
| Otros Autores: | |
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| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Firenze, Italy :
Firenze University Press
[2013]
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| Colección: | Premio Tesi di dottorato ;
35. |
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009746744906719 |
Tabla de Contenidos:
- Abstract
- Introduction
- 1.1 Ion channels and life
- 1.2 Ion channels properties
- 1.3 Ion channels as drug targets
- 1.4 The Patch-Clamp technique
- 1.5 The Cut-Open Voltage Clamp Fluorometry technique (COVCF)
- References
- Structural rearrangements of the cardiac Na+/Ca2+ Exchanger (NCX1) revealed by Cut-Open Voltage Clamp Fluorometry
- 2.1 Function and Topology of NCX1: State of the Art
- 2.2 Fluorometric measurements of conformational changes in NCX1
- 2.3 Methods
- 2.4 Results
- 2.5 Discussion
- References
- Calcium Sensitivity of the human BKCa channel: the Role of Loop aG - ßG in the RCK1 domain
- 3.1 BKCa channels and Physiology
- 3.2 Structure of BKCa channel
- 3.3 Ca2+ sensitivity of BKCa channel
- 3.4 Methods
- 3.5 Results
- 3.6 Discussion
- References
- Blockade of hERG K+ channel by two novel quinazoline antimalarial drugs
- 4.1 Drugs, Arrhythmia and the hERG K+ channel
- 4.2 Methods
- 4.3 Results
- References
- The antimigraine compound Parthenolide, contained in the Tanacetum Parthenium, activates and desensitizes the TRPA1 channel
- 5.1 TRP channels
- 5.2 TRPA1 channel and Pain
- 5.3 Parthenolide as a natural analgesic product
- 5.4 Methods
- 5.5 Results
- References
- Acknowledgements.
