Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by chan...

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Detalles Bibliográficos
Autores principales:	Tveito, Aslak. author (author), Lines, Glenn T. author
Formato:	Libro electrónico
Idioma:	Inglés
Publicado:	Basingstoke Springer Nature 2015 Cham : 2016.
Edición:	1st ed. 2016.
Colección:	Lecture Notes in Computational Science and Engineering, 111
Materias:	Computer mathematics. Medicine. Optical data processing. Computational Science and Engineering. Biomedicine, general. Computer Imaging, Vision, Pattern Recognition and Graphics. Life Sciences Pharmacology and Toxicology Economics Political Economy Development International Relations International Political Economy African Studies African Economics
Ver en Biblioteca Universitat Ramon Llull:	https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009720238406719

Tabla de Contenidos:

Preface
Background: Contents and Method
One-dimensional calcium release
Models of open and state blockers
Two-dimensional calcium release
Computing theoretical drugs in the two-dimensional case
Generalized systems
Calcium-induced calcium release
Numerical release for CICR
A prototypical model of an ion channel
Inactivated ion channels
A simple model of the sodium channel
Mutations affecting the mean open time
The burst mode
Whole sale action potentials
.

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

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