Model systems in biology : history, philosophy, and practical concerns

Model systems in biology history, philosophy, and practical concerns

"Instead of arguing for a specific animal model, Striedter will review the history and philosophy of animal models in biomedical research, examining their various advantages and limitations"--

Detalles Bibliográficos
Otros Autores: Striedter, Georg F., 1962- author (author)
Formato: Libro electrónico
Idioma:Inglés
Publicado: Cambridge, Massachusetts : The MIT Press [2022]
Edición:1st ed
Colección:The MIT Press
Materias:
Animal models in research.
Animal experimentation.
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009674839306719
Tabla de Contenidos:
  • Intro
  • Contents
  • Preface
  • 1. Crises in Biomedical Research
  • 1.1 The Translatability Crisis
  • 1.2 The Replicability Crisis
  • 1.3 Reckoning with Biological Variation
  • 1.4 Which Model Is "Best"?
  • 1.5 This Book's Approach and Organization
  • 2. Philosophy of Models in Biology
  • 2.1 Abstract Models
  • 2.2 Material Models
  • 2.3 Assumptions about Model Fidelity
  • 2.4 Dealing with Biological Complexity
  • 2.5 Animal Welfare and Cognitive Dissonance
  • 2.6 Comparative Biology and August Krogh Revisited
  • 3. A History of Animal Models
  • 3.1 Eclectic Beginnings of Biology
  • 3.2 Early Experimental Medicine: Research on Pet Species
  • 3.3 Fruit Flies: The First Supermodel
  • 3.4 Laboratory Rats: The First Standardized Mammals
  • 3.5 Laboratory Mice: From Cancer Fighter to Model Organism
  • 3.6 Nonhuman Primates
  • 3.7 The Rest of the Menagerie
  • 3.8 Model System Ecology
  • 4. A History of in Vitro Models
  • 4.1 Microbial Models
  • 4.2 Cell and Tissue Culture Models
  • 4.3 Alternative Models in Toxicology
  • 4.4 Model Ecology Revisited
  • 5. Models and Therapies: Infectious Diseases, Cardiovascular Disease, and Cancer
  • 5.1 Infectious Diseases
  • 5.2 Cardiovascular Diseases
  • 5.3 Cancers
  • 5.4 Patterns of Model Use
  • 6. Neurological Disorders: Trials and Tribulations
  • 6.1 Brain and Spinal Cord Injuries
  • 6.2 Neurodegenerative Disorders
  • 6.3 Neuropsychiatric Disorders
  • 6.4 Successes, Failures, Hopes
  • 7. Diagnosis and Recommendations
  • 7.1 Four Perspectives on Models in Biology
  • 7.2 Recommendations
  • 7.3 Conclusion
  • Appendix
  • References
  • Index.

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