Functional metabolism regulation and adaptation
Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism,...
| Otros Autores: | |
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| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Hoboken, N.J. :
John Wiley & Sons
c2004.
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| Edición: | 1st ed |
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009664729106719 |
Tabla de Contenidos:
- FUNCTIONAL METABOLISM: REGULATION AND ADAPTATION; CONTENTS; Preface; Contributors; Chapter 1 Principles of Metabolic Control; Key Concepts; Metabolic Renaissance In Post Genome Era?; Metabolic Engineering; Metabolic Regulation versus Metabolic Control; Complexity of Metabolism and Concept of Biochemical Unity; Basis of Metabolic Control; Pacemaker Enzymes; Identification of a Pacemaker Enzyme; Enzyme Purification; Cautionary Note about Relating In Vitro Kinetic Studies of a Purified Enzyme to Its In Vivo Function and Control; Compartmentation of Metabolism
- Formulation of a Theory of Metabolic ControlMetabolic Control Analysis; Mechanisms of Metabolic Control; Coarse Metabolic Control; Fine Metabolic Control; Concluding Remarks; Chapter 2 Enzymes: The Basis of Catalysis; Introduction; Enzyme Structure; Thermodynamics and Kinetic Theory of Enzyme Function; Thermodynamic Aspects of Kinetic Function: Processes Not Under Enzyme Control; Cellular Equilibria and Enzymes; Reaction Rate Theories; How Enzymes Influence Reaction Rates; How Enzyme-Catalyzed Reactions Occur: Lysozyme as a Model of Transition State Theory
- When Enzymes Need Extra Help: Coenzymes and Their FunctionsCoenzymes That Transfer High Energy Phosphate; Coenzymes That Accept and Donate Electrons; Coenzymes That Activate Substrates; Kinetic Mechanisms of Enzyme Action; Development of Rate Equations: Simple Solution Kinetics; The Haldane Relationship; Multisubstrate Reactions; Cooperative Enzyme Mechanism; Allosteric Enzyme Activation and Inhibition; Enzyme Inhibition; Temperature Effects on Enzyme Function; Estimating Kinetic Parameters from Enzyme Velocity Data (the Influence of Error Structure)
- Chapter 3 Enzymes in the Cell: What's Really Going On?Introduction; Basic Enzyme Mechanism Under In Vivo Conditions; Effect of Enzyme-Substrate Binding; Effect of Reaction Reversibility; Effect of Substrate and Product Binding Combined with Reaction Reversibility; Time Course of the Complete Enzyme Mechanism; Simple Enzyme Systems; Simple Enzyme Pathways under In Vivo Conditions; Thought Experiment: Regulating Flux In Vivo; Mathematical Modeling of the Linear System; Branch Points and Irreversible Enzymes in Pathways; Simple Enzyme Pathways and Crossover Plots
- Basics of Metabolic Control AnalysisMCA Analysis and Metabolic Pathways; Controlling Pathway Flux under In Vivo Conditions: Direct Calculation of Control Coefficients; Controlling Pathway Flux under In Vivo Conditions: Indirect Calculations of Control Coefficients; Relating Flux Control Coefficients to Pathway Regulation; Potential of an Enzyme to Be Regulated; Metabolic Simulation; Supply versus Demand; Feedback Inhibition; Formation of Multienzyme Complexes; Chapter 4 Signal Transduction Pathways and the Control of Cellular Responses to External Stimuli
- Function and Structure of Signaling Pathways
