Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy

Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy

In the two last decades, proteases have constituted one of the primary and important targets in drug discovery. The U.S. FDA has approved more than 12 protease therapies in the last 10 years, and a number of next-generation or completely new proteases are under clinical development. Protease inhibit...

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Detalles Bibliográficos
Otros Autores: Kwok, Hang Fai (Editor), Shaw, Christopher (Otro), Walker, Brian
Formato: Libro electrónico
Idioma:Inglés
Publicado: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
Materias:
Research & information: general
MMP
MMP2
MMP9
MMP7
MMP14
matrix metalloproteases
PDAC
pancreatic cancer
Bowman–Birk inhibitor
ranacyclin
trypsin inhibitor
structure–activity relationship
synergistic effect
Gentamicin
matrix metalloproteinase
extracellular matrix
nuclei
cancer
apoptosis
immune response
cysteine protease inhibitor
stefin
signal peptide
parasite
phylogenetic analysis
diversification
protein structure
vascular endothelial growth factors (VEGFs)
VEGF-A
PlGF
VEGF-B
VEGF-C
VEGF-D
angiogenesis
lymphangiogenesis
CCBE1
proteases
ADAMTS3
plasmin
cathepsin D
KLK3
prostate-specific antigen (PSA)
thrombin
wound healing
metastasis
proteolytic activation
vascular biology
lymphedema
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009654398806719

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