Actinomycetes The Antibiotics Producers

Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibi...

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Bibliographic Details
Other Authors:	Stegmann, Evi (Editor), Mast, Yvonne (Other)
Format:	eBook
Language:	Inglés
Published:	Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
Subjects:	Research & information: general Biology, life sciences Streptomyces biogeography comparative genomics diversification secondary metabolite biosynthetic gene clusters SMGC natural products streptomyces rishirilide biosynthesis polyketides polynucleotide phosphorylase ribonuclease regulation promoter RNA decay polyadenylation (p)ppGpp antibiotic antibiotics geomicrobiology Illumina sequencing microbiome diversity Actinobacteria Cave microbiology secondary metabolite rare Actinobacteria Amycolatopsis unculturability siderophore glycopeptide antibiotics dbv cluster regulatory genes StrR LAL LuxR solo dalbavancin A40926 Streptomyces lividans secretion pathways secretory proteins signal peptides actinomycetes teicoplanin van resistance genes Streptomyces tsukubaensis tacrolimus FK506 omics screening secondary metabolism differentiation elicitors morphology liquid cultures metagenomics rare actinomycetes dereplication metabolomics genome mining secondary metabolites novel compounds physicochemical screening physical and chemical properties structural diversity biological activity Actinoallomurus antibiotics polyethers lysolipin minimal PKS II cyclases benz[a]naphthacene quinone tridecaketide aromatic polyketide pentacyclic angular polyphenol extended polyketide chain actinobacteria β-lactamase resistance β-lactamase inhibitor polyketide synthases acyltransferases engineering new bioactive compounds symbiosis drug discovery chemical ecology culture-based approaches strain specialized metabolites biosynthetic gene cluster
See on Biblioteca Universitat Ramon Llull:	https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009653941806719