Computer-aided vaccine design
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a...
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| Formato: | Libro electrónico |
| Idioma: | Inglés |
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Cambridge, UK :
Woodhead Publishing
2013.
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| Edición: | 1st edition |
| Colección: | Woodhead Publishing series in biomedicine ;
no. 23. |
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| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009628826706719 |
Tabla de Contenidos:
- Cover; Computer-aided vaccine design; Copyright; Contents; List of figures; List of abbreviations; About the authors; Preface; 1. MHC and T cell responses; 1.1 Genetic organization of the MHC; 1.2 MHC structure; 1.3 MHC function; 1.4 Peptide binding; 1.5 Bibliography; 2. Immunoglobulins and B cell responses; 2.1 Types of immunoglobulins; 2.2 Immunoglobulin structure; 2.3 Immunoglobulin function; 2.4 Antigen binding; 2.5 Bibliography; 3. Scientific publications and databases; 3.1 Bibliographical information; 3.2 Searching the literature
- 3.3 General databases containing information on genes and proteins3.4 Immunological databases; 3.5 Small molecule databases; 3.6 Bibliography; 4. Database design; 4.1 Fundamentals of database design; 4.2 ER diagram; 4.3 Normalization and normal forms; 4.4 Bibliography; 5. Computational T cell vaccine design; 5.1 Sequence- based methods; 5.2 Structure- based methods; 5.3 Broad- based T cell vaccine design; 5.4 Bibliography; 6. Computational B cell vaccine design; 6.1 Sequence- based methods; 6.2 Structure- based methods; 6.3 Bibliography; 7. Infectious disease informatics
- 7.1 Infectious diseases in history7.2 Microbial sequence analysis; 7.3 Detecting natural selection inmolecular evolution; 7.4 Bibliography; 8. Vaccine safety and quality assessments; 8.1 Assessment of ADME/Tox deficiencies; 8.2 Assessment of allergenicity; 8.3 Bibliography; 9. Vaccine adjuvant informatics; 9.1 Virtual combinatorial library; 9.2 Chemical file formats; 9.3 Considerations for virtual library design; 9.4 Bibliography; Index
