Hepatic circulation physiology and pathophysiology
The Hepatic circulation is unique among vascular beds. The most obvious unique features include the dual vascular supply; the mechanism of intrinsic regulation of the hepatic artery (the hepatic arterial buffer response); the fact that portal blood flow, supplying two thirds of liver blood flow, is...
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | Inglés |
| Published: |
[San Rafael, Calif.?] :
Morgan & Claypool Life Sciences
2010.
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| Series: | Colloquium series on integrated systems physiology ;
#1. |
| Subjects: | |
| See on Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009622258506719 |
Table of Contents:
- 1. Historical perspectives
- 2. Overview
- Microcirculation
- Hepatic microvascular zones
- Intrahepatic flow distribution
- Kupffer cells
- Stellate cells
- Sinusoidal endothelial cells
- The space of mall
- 3. Fluid exchange
- Flow-limited distribution of blood-borne substances
- Ascites formation
- Effects of drugs on fluid exchange
- Effects of hepatic nerve stimulation
- Blood flow and hepatic clearance of drugs and hormones
- 4. Capacitance
- Hepatic blood volume
- Capacitance functions in diseased livers
- 5. Resistance in the hepatic artery
- Intrinsic blood flow regulation: the hepatic arterial buffer response and autoregulation
- Metabolism and hepatic blood flow
- Portal flow regulation of hepatic arterial flow
- Autoregulation
- Quantitative aspects of the HABR
- Roles of the HABR
- Clinical relevance
- Unresolved issues
- Extrinsic influences
- Caffeine
- Vasodilators
- Carbon monoxide
- Hydrogen sulfide
- 6. Resistance in the venous system
- Essential assumptions
- Passive distensibility
- 7. Fetal and neonatal hepatic circulation
- 8. In vivo pharmacodynamic approaches
- Resistance or conductance
- Index of contractility
- Surgical preparation considerations
- Effect of vasoactive drugs on the hepatic artery when administered intravenously
- 9. Nitric oxide
- Shear stress
- 10. Adenosine
- 11. Hepatic nerves
- Extrinsic nerve supply
- Intrinsic nerves
- Developmental aspects
- Vascular responses
- The hepatic artery
- Basal tone
- Reflex activation
- Neurovascular approach in vivo
- Blood flow distribution
- Venous resistance vessel responses to sympathetic nerve stimulation
- Presinusoidal or portal responses
- Hepatic venous resistance responses
- Hepatic blood volume
- Stressed and unstressed volume
- Responses to direct nerve stimulation
- Reflex control of hepatic capacitance
- Hepatic fluid exchange
- Noradrenaline overflow
- Neurotransmitters and neuromodulation
- Disease states
- Technical considerations (avoid the sucker punch)
- 12. Hepatic circulation and toxicology
- Hepatic blood flow
- Veno-occlusive toxins
- Heterogeneity of perfusion
- Capillarization
- Ethanol
- Methodological considerations
- Free radicals and antioxidants
- Samec
- 13. Hepatorenal syndrome
- 14. Integrative hepatic response to hemorrhage
- 15. Blood flow regulation of hepatocyte proliferation
- 16. Multiple mechanisms maintaining a constant hepatic blood flow to liver mass ratio
- Overview
- Hepatic compliance
- The HABR
- The hepatorenal reflex
- Modulation of vasoconstrictors by adenosine and nitric oxide
- Blood flow regulation of hepatocyte proliferation
- 17. Pathopharmacology and repurposing drugs as a research strategy
- The pathology, the hepatorenal syndrome
- References.
