Inflammation and the microcirculation
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of i...
| Autor principal: | |
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| Otros Autores: | |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
[San Rafael, Calif.?] :
Morgan & Claypool
2010.
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| Colección: | Colloquium series on integrated systems physiology ;
#8. |
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009622252206719 |
Tabla de Contenidos:
- 1. Introduction
- 2. Historical perspectives
- 3. Anatomical considerations
- Microvascular unit
- Arterioles
- Capillaries
- Venules
- Vessel wall components
- Endothelial cells
- Vascular smooth muscle
- Pericytes
- Perivascular auxiliary cells
- Mast cells
- Macrophages
- Fibroblasts
- 4. Impaired vasomotor responses
- Blood flow changes
- Endothelium-dependent vasodilation
- 5. Capillary perfusion
- 6. Angiogenesis
- Relevance to inflammation
- Mediators of the angiogenic response
- Vascular endothelial cell growth factor
- Cytokines and chemokines
- Reactive oxygen and nitrogen species
- Lymphangiogenesis
- 7. Leukocyte-endothelial cell adhesion
- Adhesion molecules
- Intraorgan heterogeneity of adhesion
- Selectins
- Endothelial cells immunoglobulin-like adhesion molecules
- Leukocyte integrins
- Chemical mediators
- Pro-adhesive mediators
- Anti-adhesive mediators
- Role of hydrodynamic forces
- Cytotoxicity of adherent leukocytes
- 8. Platelet-vessel wall interactions
- Platelet activation: mechanisms and consequences
- Platelet-endothelial adhesion
- Platelet-leukocyte adhesion
- Platelet-leukocyte aggregates
- 9. Coagulation and thrombosis
- Interdependence of coagulation and inflammation
- Inflammation-induced microvascular thrombosis: site-specific responses
- Chemical mediators of inflammation-enhanced thrombosis
- Reactive oxygen and nitrogen species
- 10. Endothelial barrier dysfunction
- Site of inflammation-induced barrier failure
- Role of circulating blood cells
- Leukocytes
- Platelets
- Role of perivascular cells
- Reactive oxygen and nitrogen species
- Epilogue
- References.
