Regulation of vascular smooth muscle function
Vascular smooth muscle (VSM) constitutes most of the tunica media in blood vessels and plays an important role in the control of vascular tone. Ca2+ is a major regulator of VSM contraction and is strictly regulated by an intricate system of Ca2+ mobilization and Ca2+ homeostatic mechanisms. The inte...
| Autor principal: | |
|---|---|
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
[San Rafael, Calif.?] :
Morgan & Claypool Life Sciences
2010.
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| Colección: | Colloquium series on integrated systems physiology ;
#7. |
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009622248506719 |
Tabla de Contenidos:
- 1. Introduction
- 2. Ca2+ Release from the Intracellular Stores
- 2.1 Inositol Trisphosphate-Induced Ca2+ Release
- 2.2 Ca2+-Induced Ca2+ Release
- 3. Ca2+ Entry from the Extracellular Space
- 3.1 Ca2+ Leak
- 3.2 Voltage-Gated Ca2+ Channels
- 3.3 Receptor-Operated (Ligand-Gated) Ca2+ Channels
- 3.4 Store-Operated Ca2+ Channels
- 3.5 Stretch-Activated Ca2+ Channels
- 4. Mechanisms of Ca2+ Homeostasis
- 4.1 Plasmalemmal Ca2+-ATPase
- 4.2 The Sodium-Calcium Exchanger
- 4.3 Sarcoplasmic Reticulum Ca2+-ATPase
- 4.4 Mitochondria and Ca2+
- 5. Ca2+-Dependent Myosin Light Chain Phosphorylation
- 5.1 Intracellular Free Ca2+ Concentration
- 5.2 Ca2+-Dependent Myosin Light Chain Phosphorylation
- 5.3 Evidence for Other Mechanisms of Smooth Muscle Contraction
- 6. Protein Kinase C
- 6.1 PKC Structure and PKC Isoforms
- 6.2 PKC Substrates
- 6.3 Tissue Distribution of PKC
- 6.4 Subcellular Distribution of PKC
- 6.5 Mechanisms of PKC Translocation
- 6.5.1 Conformation-Induced Changes in Hydrophobicity
- 6.5.2 Lipid Modification
- 6.5.3 Phosphorylation
- 6.5.4 Targeting Sequences
- 6.6 Functions of PKC in VSM
- 6.7 PKC Activators
- 6.8 PKC Inhibitors
- 6.9 Protein Kinase Cascades during VSM Contraction
- 7. Rho Kinase in Vascular Smooth Muscle
- 7.1 ROCK Structure and Isoforms
- 7.2 Tissue Expression of ROCK
- 7.3 Subcellular Distribution of ROCK
- 7.4 Regulation of ROCK Activity
- 7.5 ROCK Substrates
- 7.6 ROCK and VSM Function
- 7.7 Rho Kinase Inhibitors
- 8. Vascular Smooth Muscle Dysfunction and Vascular Disease
- 9. Summary
- References
- Author biography.
