Regulation of endothelial barrier function
The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular en...
| Autor principal: | |
|---|---|
| Otros Autores: | |
| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
[San Rafael, Calif.?] :
Morgan & Claypool
2011.
|
| Colección: | Colloquium series on integrated systems physiology ;
#13. |
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009622035306719 |
Tabla de Contenidos:
- 1. Introduction
- 2. Structure and function of exchange microvessels
- Microvascular blood-tissue exchange
- Physical forces governing fluid filtration
- Solute transport across the microvascular wall
- Convection vs. diffusion
- The capillary pore theory
- Physiological factors affecting fluid/solute flux
- Hemodynamics
- Lymphatic drainage
- Endothelial barrier properties
- Leukocytes and endothelial barriers
- 3. Methods for measuring permeability
- Analysis of fluid filtration (Kf )
- Measuring Kf in intact tissues
- Analysis of hydraulic conductivity (Lp)
- Measuring Lp with colorimetric dyes
- Analysis of solute permeability coefficient (Ps)
- The isolated, perfused microvessel technique
- Analysis of the osmotic reflection coefficient ([sigma])
- General indicators of plasma extravasation
- Intravital microscopic measurement of transvascular flux
- Assessment of barrier function in cultured endothelial cells
- Transwell solute flux assays
- Transendothelial electrical resistance measurements
- 4. The endothelial barrier
- Transcellular permeability: vesicular transcytosis
- Paracellular permeability: cell-cell junctions
- Adherens junctions
- Tight junctions
- Extracellular barriers: focal adhesions
- The endothelial cytoskeleton
- Microtubules
- Intermediate filaments
- Actin filaments
- Actomyosin contractile machinery
- 5. Signaling mechanisms in the regulation of endothelial permeability
- Initiation of signaling: endothelial receptors
- Receptor tyrosine kinases
- G-protein-coupled receptors
- Integrin receptors
- Intracellular signal transduction: second messengers
- Calcium
- Camp
- No-CGMP
- Protein kinases and phosphatases
- Myosin light-chain kinase
- Myosin light-chain phosphatase
- Src family kinases
- Protein kinase C
- Focal adhesion kinase
- Small GTPases
- Proteases and the extracellular matrix
- MMPs
- ADAMs
- Fibrinogen
- 6. Endothelial barrier protectors
- Phospholipids
- Sphingosine-1-phosphate
- Activated protein C
- Angiopoietins
- 7. Pathophysiology and clinical relevance
- Burn edema
- ALI/ARDS and sepsis
- Ischemia-reperfusion injury
- Diabetes mellitus
- Tumor angiogenesis and metastatic migration
- Conclusion
- References.
