Regulation of cardiac contractility
Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics...
| Autor principal: | |
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| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
[San Rafael, Calif.?] :
Morgan & Claypool Life Sciences
2011.
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| Colección: | Colloquium series on integrated systems physiology ;
#18. |
| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009622020606719 |
Tabla de Contenidos:
- Introduction: contractility and the integrative biology of the myocardium
- Contractility in the modern context
- Control of cardiac contractility is critical to the matching of cardiac output to venous return during exercise with little change in end diastolic volume and with tuning of the dynamics of contraction and relaxation to heart rate
- Control of contractility is at the cellular level of organization
- Left ventricular diastolic and systolic pressure, ejection, and relaxation reflect sarcomeric mechanical properties
- Integration of sarcomere mechanics with cardiac function clarifies the meaning of preload, afterload, and contractility
- Pressure volume loops provide a quantification of contractility
- Phosphorylations of regulatory proteins in excitation contraction coupling modify contractility by controlling cellular Ca2+ fluxes, the response of the myofilaments to Ca2+, and the kinetics of the cross-bridge cycle
- Contractility may be altered by a variety of mechanisms not involving a prominent role for the autonomic nervous system
- Cardiac function curves provide a compact graphical representation of regulation of CO and SV
- Heart failure as a failure of contractility
- References
- Author biography.
