Neurobiology of Huntington's disease applications to drug discovery
In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse...
| Otros Autores: | , |
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| Formato: | Libro electrónico |
| Idioma: | Inglés |
| Publicado: |
Boca Raton :
CRC Press/Taylor & Francis Group
2010.
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| Colección: | Frontiers in neuroscience (Boca Raton, Fla.)
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| Materias: | |
| Ver en Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009621456606719 |
Tabla de Contenidos:
- ch. 1. Huntington's disease : clinical features and routes to therapy / Henry L. Paulson and Roger L. Albin
- ch. 2. Huntington's disease pathogenesis : mechanisms and pathways / Albert R. La Spada, Patrick Weydt, and Victor V. Pineda
- ch. 3. Protein interactions and target discovery in HD / John P. Miller and Robert E. Hughes
- ch. 4. Target validation for Huntington's disease / Seung P. Kwak, James K.T. Wang, and David S. Howland
- ch. 5. High-throughput and high-content screening for Huntington's disease therapeutics / Hemant Varma, Donald C. Lo, and Brent R. Stockwell
- ch. 6. Value of invertebrate genetics and biology to develop neuroprotective and preventive medicine in Huntington's disease / Christian Neri
- ch. 7. Mouse models for validating preclinical candidates for HD / X. William Yang and Michelle Gray
- ch. 8. Pharmaceutical development for HD / Richard J. Morse ... [et al.]
- ch. 9. RNA and DNA-based therapies for Huntington's disease / Meghan Sass and Neil Aronin
- ch. 10. Recombinant intrabodies as molecular tools and potential therapeutics for Huntington's disease / Ali Khoshnan ... [et al.]
- ch. 11. Biomarkers to enable the development of neuroprotective therapies for Huntington's disease / Steven M. Hersch and H. Diana Rosas
- ch. 12. Huntington disease : clinical experimental therapeutics / Ray Dorsey and Ira Shoulson.
