A master regulator of oxidative stress the transcription factor Nrf2
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. The...
| Other Authors: | , , , |
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| Format: | eBook |
| Language: | Inglés |
| Published: |
Rijeka, Croatia :
IntechOpen
2016
[2016] |
| Subjects: | |
| See on Biblioteca Universitat Ramon Llull: | https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009437993306719 |
| Summary: | Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways. |
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| Physical Description: | 1 online resource (210 pages) : illustrations |
| Bibliography: | Includes bibliographical references. |
| ISBN: | 9789535154624 9789535128380 |
| Access: | Open access |
