Application of genetically encoded indicators to mammalian central nervous system

Genetically encoded indicators emerged as promising tools for cell type-specific and chronic recording of neuronal population activity. Since publication of the first prototypical genetically encoded Ca2+ indicators (Cameleons) in 1997, we have witnessed remarkable evolution of the field, with rapid...

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Detalles Bibliográficos
Otros Autores: Yoshiyuki Yamada (auth), Yamada, Yoshiyuki, editor (editor), Mikoshiba, Katsuhiko, 1945- editor
Formato: Libro electrónico
Idioma:Inglés
Publicado: [Place of publication not identified] : Frontiers Media SA 2016
2016.
Colección:Frontiers Research Topics,
Materias:
Ver en Biblioteca Universitat Ramon Llull:https://discovery.url.edu/permalink/34CSUC_URL/1im36ta/alma991009430233506719
Tabla de Contenidos:
  • Editorial: application of genetically encoded indicators to mammalian central nervous system
  • Monitoring activity in neural circuits with genetically encoded indicators
  • Putting a finishing touch on GECIs
  • Genetically encoded Ca²⁺ indicators; expanded affinity range, color hue and compatibility with optogenetics
  • Investigating neuronal function with optically controllable proteins
  • Exploration of genetically encoded voltage indicators based on a chimeric voltage sensing domain
  • Engineering a genetically-encoded SHG chromophore by electrostatic targeting to the membrane
  • Imaging activity in astrocytes and neurones with genetically encoded calcium indicators following in utero electroporation
  • Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse
  • Wide-field Ca²⁺ imaging reveals visually evoked activity in the retrosplenial area
  • Habituation of glomerular responses in the olfactory bulb following prolonged odor stimulation reflects reduced peripheral input.