Atypical Chemokine Receptor 4 (ACKR4) B cell aplasia BAP1 BiFab CAR T CD19-CAR-T CD28 CTLA-4 DNA methylation Fab IDO inhibitor IFN-γ IL-7 IL15 KIR MICA/B mAb Medicine NK cells NKG2D PD-1 PD-L1 RNA methylation S-adenosylmethionine (SAM) T cells T-cell priming TCR diversity TIL Treg cells adaptive immunity anti-CD20 antibody