16S rRNA metagenomics Antarctica IclR family regulator Marisediminicola NdgRyo Odiel marshlands Penicillium chrysogenum Stachybotrys Streptomyces Streptomyces pratensis Streptomyces sp. SCSIO 40010 actinobacteria amino compound antibacterial antibacterial activity antifungal antimicrobial antimicrobial activity archaea bacillibactin bacillomycin biosynthesis biosynthetic gene clusters carotenoid comparative genomics cytotoxicity drug discovery ecotype fatty acid amide fibrinolytic activity