1H-indole 3 4-b]indol-4-one 5-dihydro-4H-pyrimido[5 Benzodioxole Crystal structure DFT DFT study HBV HOMO-LUMO Hirshfeld surface analysis Imidazole Nitrofurantoin-4-dimethylaminopyridine (NF-DMAP) salt Pharmaceutical chemistry Raman spectroscopy Semicarbazone adefovir dipivoxil carbamazepine cocrystal cocrystal formation crystal habit crystal structure crystal structure analysis dehydration dicarboxylic acid dissolution famotidine famoxadone hepatitis B hydrate