Aspergillaceae Aspergillus Aspergillus candidus Aspergillus clavatus BK (Maxi-K) channel ECD calculations EGFR HER2 IDH1 inhibitory activity NMR data calculations Penicillium raistrickii Penicillium sp. TJ403-1 TNF-? Talaromyces Talaromyces purpurogenus antibacterial antibacterial activity antifungal activity aspetritone bioactive products bis-indolyl benzenoids breast cancer breviane spiroditerpenoid candidusin chromone coumarin cytotoxic cytotoxicities cytotoxicity diastereomers