COR15A IDP Kinase-inducible domain interacting domain Late embryogenesis abundant Nuclear magnetic resonance PAGE4 Research & information: general Trifluoroethanol binding mechanism coactivators conformational ensemble conformational plasticity depletion interaction diffusion disease-related proteins drug design dynamic configuration electrostatics entropic force extremely fuzzy complex free energy landscape functional segments fuzzy interactions gene regulation glucocorticoid receptor intrinsic disordered protein intrinsically disordered intrinsically disordered protein intrinsically disordered proteins intrinsically disordered regions