3D cell culture 3D cell culture system MEMS PDMS SH-SY5Y cells angiogenesis barrier permeability beating force bio-mechanical property biomechanics biomimetic oxidation cardiac 3D tissue cell cell culture compression drug absorption drug efficacy drug hepatotoxicity drug metabolism endothelial cell activation epithelial-endothelial interface fluoroelastomer functional neuron imaging high-throughput screening human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM) image-based screening integrated pump ischemia/reperfusion injury lattice light-sheet microscopy liver-on-a-chip