Drosophila melanogaster GSK3 (glycogen synthase kinase 3) adult stem cells advanced glycated end products aging aging-related disorders arterial aging blood-brain barrier cell cycle cell signaling cellular quiescence circadian diabetes differentiation electron microscopy hematopoietic stem cell aging immunosenescence inflammaging inflammation lifespan longevity genes low-dose fluvastatin and valsartan combination mechanisms of quiescence entry and exit mechanisms of quiescence maintenance melatonin metabolism microRNAs mitochondria nanomedicine protein kinases