2-keto-3-deoxygluconate 2G ethanol 5-hydroxymethylfurfural 5-hydroxymethylfuroic acid Antarctica and homology modelling Bacillus subtilis lipase A DNase Fervidobacterium Glaciozyma antarctica Lactobacillus LysM domains NDM-24 New Delhi metallo-β-lactamase RNase RSM S. cerevisiae SHIF Saccharolobus solfataricus Sulfolobus solfataricus Technology: general issues Thermoplasma acidophilum aldohexose dehydrogenase archaea artificial neural network asymmetric synthesis bio-based chemicals bioactive peptides biocatalysis biodiesel biotransformation